6W1S


Conserved Protein Domain Family
Med18

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pfam09637: Med18 (This model is not part of the current CDD release)
Med18 protein
Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators.
Statistics
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PSSM-Id: 518981
Aligned: 21 rows
Threshold Bit Score: 154.538
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W1S_M         1 NMMEYLLQGSVLDHSLESLIHRLRGLCdN--MEPETFLDHEMV-------------------FLLK--GQQASPFVLRAR 57  house mouse
Q0USA0         2 YELLLYGQVPVGRHEQVLKILAGVAAM-Q--PLRILERCIIYKpqrep----------eepgLNVRrgGTQNIALKQGNK 68  Parastagonospor...
Q5B128         2 HELLLFASVPSHQHHELLQQLTGLTAM-Q--PRHCLERRLIFKatrk------------pdlANMRsgTGQ---GPDIVR 63  Aspergillus nid...
Q1E065         2 HEHSLFAPVPAAQHHDLLQQLAGVTAM-Q--PNRIYERRLVFKpyrk------------pgyLKPRpgGSQDVQAPEVQR 66  Coccidioides im...
1_pfamImport   1 HELFLSASVDSEDVSRALRILQGYCGMi---PQPFIRRRLVFEgprsrtnl----kgldpsfLKKQppNKQFWWKNLNDQ 73 
XP_963380      3 VEVFLITVVPAADTTKARSVLHGYTET-RpvTHRFTRVRHVRRldqsirgipilrslqssnpKPDSlaQWQDLHSTLSRQ 81 
Q61D43        26 QECVLYGSIFVKNVPDLERRLAGL-------WIRAAKNSMSTK-------------------CRSA--LEPPVHQILRRR 77  Caenorhabditis ...
Q7QGX9        23 QEFLLQGSILDSAAENLLHRLRGLCDNvDasPETFSDIEMCFS-------------------LKLPteKTPVMTVRVRRA 83  African malaria...
Q9XZT1        23 LEYLLQGSILDSAVEHLMHRLKGLCDNvDtsPEPFHDLEVCMS-------------------LRQPn-ANQPLLLRVRRA 82  fruit fly
EDO41427      13 MEYLLQGSVAKENVETLLHRLRGLCDNtAhdATKFADHEMVYT-------------------LRNS---TNTVTFRARHS 70 
6W1S_M        58 RSMD-----------------------------------------------RAGAPWHLRYLGQPEMgdKNRHALVRNCV 90  house mouse
Q0USA0        69 PATAaaalyytkliqklsedd-------------fgvehgkplsadvkdgeEAKWSMRWEDQPDTGD--RGVSIRFTNTT 133 Parastagonospor...
Q5B128        64 LNKMlngqmfytqvvgplseadfdgkpsssdsqdvsmsgtheaagssydydSQPWRLEFRDTPEAGFr-STITARLAASA 142 Aspergillus nid...
Q1E065        67 LNKMlngglyhvqvvgevkltdfgthp-stvdatmggtdfgnqhqneydisNQSWRIEFKDIPDAGTg-SAVTSRLISTS 144 Coccidioides im...
1_pfamImport  74 LIRQsyvltliydvdrsqfgqp------------akelgsgedksgllpcdEVPGTLRWNDLPDPANa-AIVNSRMFIAI 140
XP_963380     82 qymltervditqdvda--------------------avaagqpvpmseqtqKGERILRFNDFPDPPNprVPQTVMQRKQI 141
Q61D43        78 FRTEhq--------------------------------------------iQNYWQLKYIGVPEPDQk-CPTIVRKEISS 112 Caenorhabditis ...
Q7QGX9        84 QDV------------------------------------------------EAPLQLRYIGQPELGDrtRPTLVRSSLDI 115 African malaria...
Q9XZT1        83 LGR------------------------------------------------DAPFQMRYLGNPEVDLr-RPTLVRSCMDC 113 fruit fly
EDO41427      71 LADP-----------------------------------------------SAPWQLRYLGQAEMGDksRATLLRSCVEV 103
6W1S_M        91 D---IATSENLTDFLME-MGFRMDHEFVAKGHLF-RKGIMKVVVYKI-FRILVPG------------------NTDSTEA 146 house mouse
Q0USA0       134 Dl--LSGDPHAHMIATGpNRFVTEYYVEGHRFVH-GNVIIFLHRVLH-EPGVRSLevapktq-----lpdfaaLQLLDMS 204 Parastagonospor...
Q5B128       143 Al--PKGDVVPSMNAWG-YSFVTEYVVEGDMFIY-NDIVIFLHRVLQ-YPATGQEpheprrq-----lpsfrdLAPLEKT 212 Aspergillus nid...
Q1E065       145 Rv--PYGDIVPVMKAWG-YDYVSEYVLEGDMFIL-DDTVILLHRILN-FPAKHHLqglpafy-----lpplqeMVPLDST 214 Coccidioides im...
1_pfamImport 141 D---NEKSLCKLLQDSN-HRFTREIIQECHRTVH-NNIVFTLSRYFE-VPSEFQEvdgnsrpkvnsrlppfelLEPFDAE 214
XP_963380    142 DirePGPLLEQHMADSG-FSVANEYIEETYHWWDnNNLEFVLWRQYNdLPNPTPAplvqvagqanwmvpdmskMEPVAPF 220
Q61D43       113 Lv--HSQDMMTYAKSLG-LRMDYEYITQGKLWTK-GNIKILHSTLTR-TLRAGTYd----------------sSSLKSMS 171 Caenorhabditis ...
Q7QGX9       116 A---CTPHVIDFLTEMG-FRLDFEYSTKGYMFRK-GRMKITVSKILK--------------------------NMTEPIS 164 African malaria...
Q9XZT1       114 A---CTNGILEFLTEMG-FRLEFEYIAKGYMFRK-GRMKITVSKLIK-IVPGKQQd-----------------MANEPIS 170 fruit fly
EDO41427     104 S---TSENLTAFLEELG-FRFDYEVVLKGFVFYK-GHMRITVSQVFR-VRVT---------------------------- 149
6W1S_M       147 LSLSYLVELSVVAPAGQ-DMVSDDM-----RNFAEQLKPLVHLEKI----D 187 house mouse
Q0USA0       205 GAYILEVKLRVQDFKDA-ATLESGVnelkgFQKQMAGCVELSLPDRlsldT 254 Parastagonospora nodorum SN15
Q5B128       213 GSYILQAAITVQDGSNQ-ELMRTASqhlfgLREQLKSAVRLEHADRlsldT 262 Aspergillus nidulans FGSC A4
Q1E065       215 GGYLLQASITVQDSGNP-DLMKATTqrllgLKEHLKSAVRLESADRlsldT 264 Coccidioides immitis RS
1_pfamImport 215 DKWILTASVEVQNGSDP-DHMKSAMaelsgVQEEFRGCFALKAADRhtfdT 264
XP_963380    221 WMLYVRALVDANPVDRMaERMAEAHgrlgkVEKELEGVFSFMVFDRraldT 271
Q61D43       172 DSALVEISISLPESAEY-MPAAKSLr---dFADQLMPLVNMEKIDY----W 214 Caenorhabditis briggsae
Q7QGX9       165 QSYLVELSVLAPKGQDA-IAEDMRI-----FAEQLKPLVQLEKIDY----K 205 African malaria mosquito
Q9XZT1       171 QSYIVELSVVAPTGQEN-VGEEMRV-----FAEQLKPLVQLEKIDY----K 211 fruit fly
EDO41427     150 ------------------------------FHGKTHAIV-----------S 159
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