5U0S


Conserved Protein Domain Family
Med18

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pfam09637: Med18 
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Med18 protein
Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators.
Statistics
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PSSM-Id: 401539
View PSSM: pfam09637
Aligned: 21 rows
Threshold Bit Score: 147.164
Threshold Setting Gi: 156220561
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U0S_R     2 QELYLLGVVPSRRFEAVVNSLSKTLDG----PKTILEFWVVYRPKD------------VPPNLPRQPDSWLRLCSNIESH 65  fission yeast
Q0USA0     2 YELLLYGQVPVGRHEQVLKILAGVAAMq---PLRILERCIIYKPQRepe------epgLNVRRGGTQNIALKQGNKPATA 72  Parastagonospora no...
Q5B128     2 HELLLFASVPSHQHHELLQQLTGLTAMq---PRHCLERRLIFKATRkp--------dlANMRSGTGQ---GPDIVRLNKM 67  Aspergillus nidulan...
Q1E065     2 HEHSLFAPVPAAQHHDLLQQLAGVTAMq---PNRIYERRLVFKPYRkp--------gyLKPRPGGSQDVQAPEVQRLNKM 70  Coccidioides immiti...
EDO01479   2 HELFLSASVDSEDVSRALRILQGYCGMi---PQPFIRRRLVFEGPRsrtnlkgldpsfLKKQPPNKQFWWKNLNDQLIRQ 78  Sclerotinia sclerot...
Q61D43    26 QECVLYGSIFVKNVPDLERRLAGL-------WIRAAKNSMSTK---------------CRSA--LEPPVHQILRRRFRTE 81  Caenorhabditis brig...
Q7QGX9    23 QEFLLQGSILDSAAENLLHRLRGLCDNvdasPETFSDIEMCFS---------------LKLPTEKTPVMTVRVRRAQDV- 86  African malaria mos...
Q9XZT1    23 LEYLLQGSILDSAVEHLMHRLKGLCDNvdtsPEPFHDLEVCMS---------------LRQP-NANQPLLLRVRRALGR- 85  fruit fly
Q9CZ82    19 MEYLLQGSVLDHSLESLIHRLRGLCDNm--ePETFLDHEMVFL---------------LKGQ--QASPFVLRARRSMDRA 79  house mouse
EDO41427  13 MEYLLQGSVAKENVETLLHRLRGLCDNtahdATKFADHEMVYT---------------LRNS---TNTVTFRARHSLADP 74  starlet sea anemone
5U0S_R    66 D----------------ETDTEWSK----------------------NTQWSMYLEGNSEPKRe-DKCGIRPVNRAKLTN 106 fission yeast
Q0USA0    73 Aaalyytkl-iqklsedDFGVEHGKplsad------------vkdgeEAKWSMRWEDQPDTGD--RGVSIRFTNTTDLLS 137 Parastagonospora no...
Q5B128    68 LngqmfytqvvgplseaDFDGKPSSsdsqdvsmsgtheaagssydydSQPWRLEFRDTPEAGFr-STITARLAASAALPK 146 Aspergillus nidulan...
Q1E065    71 LngglyhvqvvgevkltDFGTHPSTvdatmggtdfg-nqhqneydisNQSWRIEFKDIPDAGTg-SAVTSRLISTSRVPY 148 Coccidioides immiti...
EDO01479  79 syvltli----ydvdrsQFGQPAKElgsgedk--------sgllpcdEVPGTLRWNDLPDPANa-AIVNSRMFIAID-NE 144 Sclerotinia sclerot...
Q61D43    82 Hq--------------------------------------------iQNYWQLKYIGVPEPDQk-CPTIVRKEISSLVHS 116 Caenorhabditis brig...
Q7QGX9    87 -----------------------------------------------EAPLQLRYIGQPELGDrtRPTLVRSSLDIA-CT 118 African malaria mos...
Q9XZT1    86 -----------------------------------------------DAPFQMRYLGNPEVDLr-RPTLVRSCMDCA-CT 116 fruit fly
Q9CZ82    80 -----------------------------------------------GAPWHLRYLGQPEMGDknRHALVRNCVDIA-TS 111 house mouse
EDO41427  75 -----------------------------------------------SAPWQLRYLGQAEMGDksRATLLRSCVEVS-TS 106 starlet sea anemone
5U0S_R   107 GSVTEFVEKMG-YEFSHEYIIQGLEYFFFDTTVRIYQTL-IPSQQRS--------------IKPPFHPMNEEQPWILHVY 170 fission yeast
Q0USA0   138 GDPHAHMIATGpNRFVTEYYVEGHRFVHGNVIIFLHRVLhEPGVRSLevapk-----tqlpDFAALQLLDMSGAYILEVK 212 Parastagonospora no...
Q5B128   147 GDVVPSMNAWG-YSFVTEYVVEGDMFIYNDIVIFLHRVLqYPATGQEphepr-----rqlpSFRDLAPLEKTGSYILQAA 220 Aspergillus nidulan...
Q1E065   149 GDIVPVMKAWG-YDYVSEYVLEGDMFILDDTVILLHRILnFPAKHHLqglpa-----fylpPLQEMVPLDSTGGYLLQAS 222 Coccidioides immiti...
EDO01479 145 KSLCKLLQDSN-HRFTREIIQECHRTVHNNIVFTLSRYFeVPSEFQEvdgnsrpkvnsrlpPFELLEPFDAEDKWILTAS 223 Sclerotinia sclerot...
Q61D43   117 QDMMTYAKSLG-LRMDYEYITQGKLWTKGNIKILHSTLTrTLRAGTY----------------DSSSLKSMSDSALVEIS 179 Caenorhabditis brig...
Q7QGX9   119 PHVIDFLTEMG-FRLDFEYSTKGYMFRKGRMKITVSKILk-------------------------NMTEPISQSYLVELS 172 African malaria mos...
Q9XZT1   117 NGILEFLTEMG-FRLEFEYIAKGYMFRKGRMKITVSKLIkIVPGKQQ-----------------DMANEPISQSYIVELS 178 fruit fly
Q9CZ82   112 ENLTDFLMEMG-FRMDHEFVAKGHLFRKGIMKVVVYKIFrILVPGNT------------------DSTEALSLSYLVELS 172 house mouse
EDO41427 107 ENLTAFLEELG-FRFDYEVVLKGFVFYKGHMRITVSQVFrVRVT------------------------------------ 149 starlet sea anemone
5U0S_R   171 THVADASNQVAMAKAEANLTKVKTLLSAFCDLK-------NVR 206 fission yeast
Q0USA0   213 LRVQDFKDAATLESGVNELKGFQKQMAGCVELSlpdrlslDTR 255 Parastagonospora nodorum SN15
Q5B128   221 ITVQDGSNQELMRTASQHLFGLREQLKSAVRLEhadrlslDTR 263 Aspergillus nidulans FGSC A4
Q1E065   223 ITVQDSGNPDLMKATTQRLLGLKEHLKSAVRLEsadrlslDTR 265 Coccidioides immitis RS
EDO01479 224 VEVQNGSDPDHMKSAMAELSGVQEEFRGCFALKaadrhtfDTK 266 Sclerotinia sclerotiorum 1980 UF-70
Q61D43   180 ISLPESAEYMPAAKSLRD---FADQLMPLVNMEki----dyWK 215 Caenorhabditis briggsae
Q7QGX9   173 VLAPKGQDAIAEDMRI-----FAEQLKPLVQLEki----dyKR 206 African malaria mosquito
Q9XZT1   179 VVAPTGQENVGEEMRV-----FAEQLKPLVQLEki----dyKR 212 fruit fly
Q9CZ82   173 VVAPAGQDMVSDDMRN-----FAEQLKPLVHLEki----dpKR 206 house mouse
EDO41427 150 ---------------------FHGKTHAIV-----------SR 160 starlet sea anemone
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