Conserved Protein Domain Family
Sen15

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pfam09631: Sen15 (This model is not part of the current CDD release)
Sen15 protein
The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this hetero-tetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold. Each monomer consists of three alpha-helices and a mixed antiparallel/parallel beta-sheet. Two monomers of Sen15 fold with two monomers of Sen34, one of the two catalytic subunits, to form an alpha2-beta2 tetramer as part of the functional endonuclease assembly.
Statistics
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PSSM-Id: 518977
Aligned: 39 rows
Threshold Bit Score: 76.8912
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007812814  19 TVLHNLADQHDWTCLELRDGPEqpRSLIKGLPPKrlYLHpddqiaalaheeatgeklfqnpeYELVLPVHITETWSLSRF 98 
EFX67900      20 QLYKDLKFVRGNEDVKIHQFDEldLVYITGYLPDaeRQQ------------------------EILLPLAADEAISMKKI 75 
Q7QJN3        27 RVYIHLQEEKHMHDVQYTYEKRlqLFYLTARKEPdgPS-------------------------DLFIPSLTTNALNLVQL 81  Anopheles gambi...
XP_001747355 279 LTYVDLSEAKNWRSLDIRHHERlrLVYLVGRMGLkkPL-------------------------EVIIPALADRDLQLQTM 333
Q55DG3        28 QIYVDLVFLKKWNKVEFKHNDQ--LIYLHAIENLnnPNN-----------------------YNIVIPCKSTSIWSVESI 82  Dictyostelium d...
EDO44774     486 LVYLDLCEAKYWREVEIHSCEKlkIFYITGKPKKnqDL-------------------------EVIVPVNATLSLSMQQM 540
XP_002191153  72 LVYLDLLEGRNWHEVQPVGVAElqLVCLHARAKEqeGL-------------------------QVMVPVPAHILISHERL 126
XP_004078937  40 LVCMDLTEVRRWKEVSSVKSPElrLILLEGKEKDgaPV-------------------------HTVLPLPAHQSLSHSSI 94 
NP_001093560  39 LVYMDLTEVRKWKDVVGVSCPElqAVLLEGREKEgeSV-------------------------QMIYPLPSHRSIKHREL 93 
XP_005996264  56 LVYLDLLEARNWHDVACIGSEElqLIYLQGCERAgdTP-------------------------QVVIPTPTHESLTHKRI 110
XP_007812814  99 AAVFNSVPSNGa----rPKRILLATLHNDSTVVYYL--MHEGMVK-----PRQ-N 141
EFX67900      76 GEVQKCLfhr-----hkSSRLTLALMDSDSTTVYFG--VTPGLLP-----PSDlE 118
Q7QJN3        82 KQCRETITLPDge---kPASIVLAICDGSSTVLLYR--MTSGLKEiaqklPSKgK 131 Anopheles gambiae str. PEST
XP_001747355 334 HQYYTEITDPNselntpIQSFVLGIMADDSTVVYYR--FSQGLQA-----PPEsL 381
Q55DG3        83 KKMFNNLNNLPi----dCKSFTLGIQDEDSSISYYElsFNTGLSD-----PINsL 128 Dictyostelium discoideum AX4
EDO44774     541 KNLVEGVNVSGqsqderNKVATLAICDSDSSIVYYK--LFSGLEQ-----PDPpT 588
XP_002191153 127 REILKKASLPPedp-dtLLSVTLAIVETDSTIVYYK--MTDGFVM-----LDP-P 172
XP_004078937  95 CSVLDR-----------GFPVLLCAVASDSTLVYQR--LTDGLVT-----PEP-P 130
NP_001093560  94 RSILDR-----------GSPMLLCAVASDSTLVYQR--LCDGFLT-----PDPpV 130
XP_005996264 111 REIMKHCCDQDsredvvKMSIVLAIVESDFTVVYYK--LTDGFVV-----PDPpD 158
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