Conserved Protein Domain Family
Sen15

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pfam09631: Sen15 
Sen15 protein
The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this hetero-tetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold. Each monomer consists of three alpha-helices and a mixed antiparallel/parallel beta-sheet. Two monomers of Sen15 fold with two monomers of Sen34, one of the two catalytic subunits, to form an alpha2-beta2 tetramer as part of the functional endonuclease assembly.
Statistics
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PSSM-Id: 401534
View PSSM: pfam09631
Aligned: 43 rows
Threshold Bit Score: 74.9528
Threshold Setting Gi: 281202825
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007812814  19 TVLHNLADQHDWTCLELRDGPEqpRSLIKGLPPKRLYLHpddqiaalaheeatgeklfqnpeYELVLPVHITETWSLSRF 98  Metarhizium acr...
XP_021260848  59 LVYLDLLEGRSWHEVKHVGLAElqLVCLHAREREQGDL-------------------------QVMVPIPADVLVSHERL 113 helmeted guinea...
XP_002191153  72 LVYLDLLEGRNWHEVQPVGVAElqLVCLHARAKEQEGL-------------------------QVMVPVPAHILISHERL 126 zebra finch
XP_005996264  56 LVYLDLLEARNWHDVACIGSEElqLIYLQGCERAGDTP-------------------------QVVIPTPTHESLTHKRI 110 coelacanth
XP_012815916  31 LVYMDLLEVRNWHDVKIHGSSElhLIYLHGLEKEGCIP-------------------------QLIIPTPVSMSYSHERI 85  tropical clawed...
EDO44774     486 LVYLDLCEAKYWREVEIHSCEKlkIFYITGKPKKNQDL-------------------------EVIVPVNATLSLSMQQM 540 starlet sea ane...
XP_003728007  45 LVYLDLCEGKNWWHMEIHPCWPlhMAYITGRAFKKDDI-------------------------TAVLPLQAKATLSPSSL 99  purple sea urchin
EDQ87822     279 LTYVDLSEAKNWRSLDIRHHERlrLVYLVGRMGLKKPL-------------------------EVIIPALADRDLQLQTM 333 Monosiga brevic...
Q55DG3        28 QIYVDLVFLKKWNKVEFKHNDQ--LIYLHAIENLNNPNN-----------------------YNIVIPCKSTSIWSVESI 82  Dictyostelium d...
Q7QJN3        27 RVYIHLQEEKHMHDVQYTYEKRlqLFYLTARKEPDGPS-------------------------DLFIPSLTTNALNLVQL 81  Anopheles gambi...
XP_007812814  99 AAVFN--SVPSNga-------------------rPKRILLATLHNDSTVVYYL--MHEGMVK-----PRQ-N 141 Metarhizium acridum CQM...
XP_021260848 114 REIMK--KAALPqdd----------------pdtPLSITLAIVETDSTIVYYK--MTDGFVL-----PEPpD 160 helmeted guineafowl
XP_002191153 127 REILK--KASLPped----------------pdtLLSVTLAIVETDSTIVYYK--MTDGFVM-----LDPpD 173 zebra finch
XP_005996264 111 REIMK--HCCDQdsre---------------dvvKMSIVLAIVESDFTVVYYK--LTDGFVV-----PDPpD 158 coelacanth
XP_012815916  86 QQFMKldCTSDEaq-------------------sISSILLAIVESDSTVVYYK--LNDGFVI-----PDPpd 131 tropical clawed frog
EDO44774     541 KNLVE--GVNVSgqsq---------------derNKVATLAICDSDSSIVYYK--LFSGLEQ-----PDPpT 588 starlet sea anemone
XP_003728007 100 RTFLT--TLDPEhsslqssfktpskavipeehraKRAITLAITDSDSTIVYYK--ISDGLVP-----PDSgp 162 purple sea urchin
EDQ87822     334 HQYYT--EITDPnsel---------------ntpIQSFVLGIMADDSTVVYYR--FSQGLQA-----PPEsL 381 Monosiga brevicollis MX1
Q55DG3        83 KKMFN--NLNNLpi-------------------dCKSFTLGIQDEDSSISYYElsFNTGLSD-----PINsL 128 Dictyostelium discoideu...
Q7QJN3        82 KQCRE--TITLPdg------------------ekPASIVLAICDGSSTVLLYR--MTSGLKEiaqklPSKgK 131 Anopheles gambiae str. ...
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