Conserved Protein Domain Family
Cas6

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pfam09559: Cas6 
Cas6 Crispr
The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.
Statistics
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PSSM-Id: 401483
View PSSM: pfam09559
Aligned: 34 rows
Threshold Bit Score: 186.986
Threshold Setting Gi: 505070595
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015193897             5 EIQFALKGKTLPADHGYSLYSALKNIVLENSSQIileeertrdfppEVILSTIPGVPDRQG----------LIYLNRSSR 74  Stani...
Q3SG16                  20 DLQFELAGSTIPADNAQMLCDALLGVLPWLGEDP------------GSGIQHLKGAATNSGd--------tVLNINRRTR 79  Thiob...
jgi:Tgr7_2182           19 DVSYRIDCRCLPLDHAHALSSAVLAALPWMSEEP------------AAGVHLIHGAESGNGwyrpqdpehdLLHLSRRAR 86  Thioa...
WP_015257697            19 DVAYRIDCPRLPLDHAHALSSALLELLPWLGTED------------HAGVHLIHGAESGNGwmrpqdperdLLHLSRRAR 86  Thioa...
PRJNA62513:MARPU_10935  20 ELVFAIDCRALPVDHADALHRALIVAQPWLAETA------------GLGIHSIHGAGSQNGwerpphgtdtCLQLSRRTK 87  Maric...
ESQ14722                20 DVLFALDCRSIPVDHAFALSQALLDPAPWLSEP-------------GCAIHLIHGAGSQNGwerpehgigrQLHLSRRTK 86  uncul...
BAN69661                20 DLAFSIQCRELPVDHLYALGSALCEAAPVLTEDP------------RVAIHEIHLAGSQNGwerpdpqmgqKLVLSRRTK 87  endos...
jgi:Thivi_0540          20 DVLFAIDCKRLPVDHAHLLSTALQAALPWIAEEP------------GMALHTIHVAGSQNGwerpahgtdsELMLSRRTK 87  Thioc...
WP_015279164            20 DVQFAIDAKRIPVDHGCALGEAVLAALPWEEGQA------------ALGVHTIHVAGSQNGwqrpdhgqdqFLILSRRTK 87  Thiof...
WP_012970461            20 DLLFAIDCKRLPVDHAYALSSAVRALVPWFDEEP------------RLGVHTIHVAGSQNGwerpehspeaLIMVSRRTK 87  Alloc...
WP_015193897            75 LRLRCPSEQASQWYRlFQNQVLDIRGHLIRLVQPRLCLLEPSQTLKARLVTFHlek-wdIHDAPVYFLESCQKSLLS-LE 152 Stani...
Q3SG16                  80 LFMRVPKTRVDDMQR-LIGEQLDLGGHALRIGSFKTRDFSPFANIYAHFIDT-------GSATEEQFVQDVMRELDSrFQ 151 Thiob...
jgi:Tgr7_2182           87 FRLRVPRTRLEDARA-LVGQALRLEGHELLIGEAGVLPLQPLPALMARYVVST------PDEAEADFLARAAGALRE-LG 158 Thioa...
WP_015257697            87 LRLRVPVARVDEAAT-LIGRTLEVSGFGIGVGPMNVIPLEPLPVVFARHVVAD------PEQDEPAFLAEMAAELGR-IG 158 Thioa...
PRJNA62513:MARPU_10935  88 LRLRVPQHLSDSLLAtLPGSHIEVAGHPLTIGQGRIRSLDPNPTQFARHVVCS------AEEDENAFLERAAETLAR-IE 160 Maric...
ESQ14722                87 LCIRVPKSRIASLKNaLEGEVIKVAGSALRIGAGKQRLLSREGTLLARYVAHP------AGLNENGFLSWAVEELAG-SG 159 uncul...
BAN69661                88 LHIRAPKELRERIEQaLDGLTIEIDGHPMTIGKARVKTLSRQGTLFARHIVLEp----gEEDDENTFLMRLAKLLQA-RG 162 endos...
jgi:Thivi_0540          88 LTIRAPRARVDDILTqLPGTRLELDGHPLTVGVGKIKPLCKDATLFSRYVVTGn-----EDQDEQVFLEIAVRALSG-MG 161 Thioc...
WP_015279164            88 LTIRVPKSRADALKTaLTGRVLDVAGCRLTVGAGKERPLSKETTLFARYVVDP------HRRNEAQFLDWAAAELHA-MD 160 Thiof...
WP_012970461            88 LTIRVPSARADDLAArLQGRRIDVGGQPLTIGAAKPKPLSQETTIFARYLATDpsadaeAFADESRFLEAAAQALGA-LD 166 Alloc...
WP_015193897           153 IKGKAFIdsncdGdlALRSLKIKNKNVMGFGVVVENLNDEDSLKLQCYGLGGRKHFGCGWFY 214 Stanieria cyanosphaera
Q3SG16                 152 LRCGFIC-----G--KQQTLQSASGPLFGHSLMLHDVPPHKSLQLQDEGLGRNRLLGCGIFI 206 Thiobacillus denitrific...
jgi:Tgr7_2182          159 VPVTKLLc----G--REHVLRTPDGEVHTRSLMVADLDPHGSVELQRQGLGPMRLMGCGLFI 214 Thioalkalivibrio sulfid...
WP_015257697           159 VPASKLLs----G--LSHVLRVPGGLLHTRSLMVAELDAQSSLRLQRSGVGSDQALGCGLFI 214 Thioalkalivibrio nitrat...
PRJNA62513:MARPU_10935 161 VGVRKALc----G--RALTLVTADGPLHTRSLLLANLPPDESIRLQQHGLGSHRHLGCGLFI 216 Marichromatium purpurat...
ESQ14722               160 IRVRKAIg----G--KSTPLSTPDGPLETRSLLLADLAPDESILLQQRGLGPHHEMGCGIFL 215 uncultured Thiohalocaps...
BAN69661               163 IRVKKALc----D--TTQKIATPEGPLTTRSLLLADLRPEDSIALQQDGLGSHRHFGCGIFL 218 endosymbiont of unident...
jgi:Thivi_0540         162 IQVRKALc----G--KTTALATPDGPLQTRSLMLASLTAEESIRLQQTGLGTHRLMGCGIFI 217 Thiocystis violascens D...
WP_015279164           161 IRIRKALc----G--KAVTLATPDGPLLTRSLLLANLDVEDSVRLQRLGLGPQRGIGCGLFI 216 Thioflavicoccus mobilis
WP_012970461           167 IRVRKALc----G--KATTLHTPAGPIPTRALMLAGLTREESMRLQREGLGPHRALGCGLFI 222 Allochromatium vinosum
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