Conserved Protein Domain Family
FDF
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pfam09532: FDF 
FDF domain
The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops. It is found at the C terminus of Scd6p-like SM domains. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain.
Links
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Statistics
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PSSM-Id: 490440
Aligned: 9 rows
Threshold Bit Score: 83.6723
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_752608 430 EVPDTDYDFESANAKFNKQDLVKEAIATGSPVTEAGAHvengeVEAVDTAHHAPSTTASAYNKSASFFDNISSEARDREE 509
Q7RXT2    285 VQEAGDFDFESGLAKFNKQDLFEQMRKDDLIDEADRLV-----SHNRVPKHKPGTAGGKNLHHSENVLDMPSTILKPKLI 359 Neurospora crassa
Q96F86    198 EIPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRGip-neRPTRYRHDENILESEPIVYRRIIVPHNVSKEFCTDSG 276 human
O94752     93 MDCDEEFDFAANLEKFDKKQVFAEFREKDKKDPAKLLVs----HNKSPNRNYHHKQNVLGPSVKDEFVDLPSAGSQINGI 168 Schizosaccharomyce...
P39998     99 IKQQEDFDFQRNLGMFNKKDVFAQLKQNDDILPENRLQgh-nrKQTQLQQNNYQNDELVIPDAKKDSWNKISSRNEQSTH 177 Saccharomyces cere...
Q9C658    459 MKFTEDFDFTAMNEKFNKDEVWGHLGKSTTLDGDEDD------DSPTVDEAELPKIEAKPVYNKDDFFDSLSSNTIDRES 532 thale cress
Q9FH77    425 IEYTEEFDFEAMNEKFKKSELWGYLGRNNQRNQ----------NDYGEETAIEPNAEGKPAYNKDDFFDTISCNQLDRVA 494 thale cress
Q7RX24    441 EVPDSDFDFESSNAKFNKQEIVKEAIAGSPLGEEPAIE-----SAAPEAVADVSGVAQQAYNKSKSFFDNISSEAKDRAE 515 Neurospora crassa
Q9VTZ0    401 IKFEGDFDFEQANNKFEELRSQLAKLKVAEDGAPKPATna--tAATATATNEQVGEKVEGVHTLNGETDKKDDSGNETGA 478 fruit fly

XP_752608 510 RSGGRPGGr-----------------------------eWRGEEEKRniETFGQGS 536
Q7RXT2    360 VKETSNDF-------------------------------WNSEADDG--VINGADR 382 Neurospora crassa
Q96F86    277 LVVPSISYe-----------------------------lHKKLLSVA--EKHGLTL 301 human
O94752    169 DAVLSSSSn-----------------------------gHVTPGSKK--GSRETLK 193 Schizosaccharomyces pombe 972h-
P39998    178 QSQPQQDAq-----------------------------dDLVLEDDE--HEYDVDD 202 Saccharomyces cerevisiae S288C
Q9C658    533 QNSRPR---------------------------------FSEQRKLDt-ETFGEFS 554 thale cress
Q9FH77    495 RSGQQHNQ-------------------------------FPEHMRQVp-EAFGNNF 518 thale cress
Q7RX24    516 NNGQKPGGr-----------------------------eWRGEEQRRniETFGQGS 542 Neurospora crassa
Q9VTZ0    479 GEHEPEEDdvavcydktksffdnisceaaqdrsknkkndWRQERKLNt-ETFGVSS 533 fruit fly
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