Conserved Protein Domain Family
Ndc1_Nup

?
pfam09531: Ndc1_Nup (This model is not part of the current CDD release)
Nucleoporin protein Ndc1-Nup
Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.
Statistics
?
PSSM-Id: 518945
Aligned: 115 rows
Threshold Bit Score: 175.602
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_015210884   13 KVICWRAAASiAWSVLLLPVITALFVFLsHLDLfhpvqwisdslsvlggsyvIFSVVL---------------------- 70 
XP_012188578   24 ALRPRQTRAFvLAAVAWHLFLTSALLSTlSLSLispltl----------------------------------------- 62 
XP_011392699   24 ALRPRQTRAFiLSAVAWHLLLTSALLSTaSLSLmspltl----------------------------------------- 62 
XP_007397684   38 NVLRQRL----LSRTFLYSALFCWTLVI------------------------LTATAGrggvarlglvgalispffprtl 89 
EMD32361       45 AALRHRL----LYHIFAPSFLVSWLLVT------------------------IWSVWMqgglsglglggflsaplspwtl 96 
EPS94314       29 SVIGRRL----FYNILAPSLAYSWVLAN------------------------VWSKWSqggpsqlglwgsfvdcikpltl 80 
11_pfamImport   1 VILRRRTYHF-----CLISYLLSNIV--------------------------LWFVMLdglpalwnglr--------itt 41 
XP_007406799   18 VVLRRRACHF-----CVITFLTNLGL--------------------------LWVSMLdgspavwnflr--------vpf 58 
XP_009268324   35 LVLRKRMIRLvLLTFLSTCTIFSVSTSNlNDRIsstislnr--------------------------------------- 75 
XP_024512721   35 KFLAKRYMTLmSRVALWIAVLLSLFSAFvSGDI---------------------SKVPfavls----------------- 76  Cryptococcus n...
XP_015210884   71 -------LCLvvLVVGFFDLQYYTVVPSI----PCTK--IAL----IGKVLHPQQFIHSLAHCLMGLLvswCAAVMIGgr 133
XP_012188578   63 -aasllsFGLgvLPLLAKRKRSLSQITTPparlPSSK--AQQ----LSAALSDPTLVTLIFQHVVAFV---VLALGYAal 132
XP_011392699   63 -gvsllsFAVgvLPLLAKRKRKLSQITTPparlAPSK--AQQ----LSSALTDPALLPLVYQHVAAFV---VLALGYAal 132
XP_007397684   90 glafiiwISGv-VPVLVLRKVYLTASPAS----ASSP--SGV----FRDALNKSSTFRSLAVYLTSAS---LLTAIHVvt 155
EMD32361       97 sfaavfwCLGv-VPVVVVRKNYLTVTPTA----SLSP--STV----FQSTLTKTSTPPALLAYLCSST---LVTFMYIfm 162
EPS94314       81 lhavaiwMLGv-VPALVLRNRFLTATPTS----ASSP--SKM----FSAALVKRSTTCALVTYLASGV---ALAVVHMfl 146
11_pfamImport  42 wimgganWASatIPLMTLRRLQLTASSLY----APNR--YAK----FWAVLKSTEFITSTLFCSISGS---LLCLTYV-- 106
XP_007406799   59 wimggavWASvtIPMMMLRRSQRQKRPSS----CLTR--YQS----IVAVLGSAQHLAACVLLSISSL---LLWTCYV-- 123
XP_009268324   76 flfaavaFSLsvIPIIITRKla---------liTKPPpsPSSpsqrIKSFLLNNKTYSSTSVYALSAV---IYAISFL-- 141
XP_024512721   77 --sfpvfLSL--AFLLRVRKSFITQPYRPs--pRSSL--IGL----IVSSFWNQRVITLLFSYAVFSI---TITNVWF-- 139 Cryptococcus n...
XP_015210884  134 YqvfAKPchs---------eesHQMCLNEYHLFFLLAGAFMGYSY-----------SLLSVVKNMNYV-------SFQTI 186
XP_012188578  133 LtyrKGGwapqi-----wveshASFYLNERFLYLVGQSIVLGAVYafvsrslpspqAVASPSFDASTLtt---dtPVTIK 204
XP_011392699  133 LtyrSGGwapqv-----wveshGSLYLNERFLYLIGQSILLGTVYafllrglpspeSVASPLFDPSTLts---dtAVTIK 204
XP_007397684  156 AlvfDVRagrdprlslfvksrkHPYYLNGRLLYLISSQISLAAFY-----------VLRNVMMDRLAVrw---tgSMSAR 221
EMD32361      163 TyvyGSSssedrhlsffvkskkHPYYLNGRVLYLISSQMVISAAY-----------FFRNALLDRFVVhw---teLSTTT 228
EPS94314      147 AniyEPSpsghprfslfvksrkHPYYLNGRVLYMLFSQAVLASAY-----------LLRTVLLDRFAVrw---tqVPSQP 212
11_pfamImport 107 SaalALNenpelgl-fksvpgrGVTQISERPIFLLASCWYTALCY-----------SFSAIYHGKWHYrp---fdVSEHL 171
XP_007406799  124 AaanALNeepdlkl-fktmpgrGASQINERPIYLAASALFCAFYY-----------SFLLTYEQRFPSkr---adQPEGL 188
XP_009268324  142 AcvsTHEedaqftp--ftthkrRGWQFNERFIFFILNAIVLAISY-----------SIYQLWTDRFITrfpsnisQSISE 208
XP_024512721  140 T---LLGredmtl---fnstprHPWQLNESRFILTASNACLFLVA-----------AARDILNDNLKAd-----wPRERK 197 Cryptococcus n...
XP_015210884  187 QQYKYLrFKGtLPVVIKHSA-VQSLYSV-RNYCITYLFLgyiPRAWICTt--------------mNLSRDSTLHALdTLA 250
XP_012188578  205 HRVVAA-FTArLPRAALVAAlTSSASIL-------VYSI---VRIRMWStillv-------lgtrGVMRRLLVPSFrVEF 266
XP_011392699  205 DRVASA-FSTrLPRAASVAAlTSSTSIL-------IYSI---MRIRMWSailmv-------lgtrGMMRRLFVPSFrVDF 266
XP_007397684  222 AMNEIP-SFM-LARILTVTAsALLLTAMgTVAHIVLFGC---ARAIVIPfvfklpv---lshllrPFLAHFLRGPFaLTL 293
EMD32361      229 NPVQAR-TVR-LAQLLTMLVtVGIFSGLcVAGHTLLFGL---ARSIALPvvfripi---vsrflrPFMAHFLRGRFtLTL 300
EPS94314      213 DAPERH-PFR-LARIVGTLItIGLSVSLtTVAYATLFGC---VRSLVLPtvyalpy---ipqflrPFTAHFLRGPWtVTL 284
11_pfamImport 172 TIPQRI-WNS-LDSRIEFVRrSIIYCSAtFLP---IYLI---SRRYLIRaivf--------skytQLTKHIKPHMVmLIK 235
XP_007406799  189 MISQRI-LRT-LPTVFTRANrFSFLCSApFLP---FYLI---CRRYLIRaivf--------skyvQLTKFIKPHLVmMIK 252
XP_009268324  209 RVLTHL-KRN-LASGVKFSIiTVLTCLS-------SYFL---LKKPIYRtlatfsls-tfrphlfSLLRQNNL------- 268
XP_024512721  198 PFAQAV-KIAlFDNVWGSSR-IGFTFLWsISTPFAYCWLg--LRSFIWQwvnwrlwgvavrpflgSFARSTSKTP----- 268 Cryptococcus n...
XP_015210884  251 GllDFSLM--FHLWITGTFLLVMWYITWLLFRIYITEMYW---FPVQTTfSENASQCLPKVLTGqQPPVLKFLALQDLAL 325
XP_012188578  267 AffEVS----VRSVLFSIAATCAVETAYLLLDVYLSHPL----PPVSKY-AKFPNRLLLDGIEE-PVLFFSNHAFSELAR 336
XP_011392699  267 AyvEVS----LRTVLFSVAAVCAVETAYLLLDVYLTHPL----PAVSKH-TKFPNRLLLDGIHE-PTLFFSNHAFSELAR 336
XP_007397684  294 LtrHTGLI--FRAFMLGFLTISTWDFAENLFDTFVAEP-----INVAQA-TADPAVTLVSGTTS-QDLYYKHFAFAELAQ 364
EMD32361      301 LarHWSLI--TRTFYLGITTLAGWEFAESAFDEAVS---------VSHH-TGAPTHILVSGTTT-ADAYYKHFAYSELRE 367
EPS94314      285 LlrNWSLV--WRTFFLGVTTAACWELAESPLDEPVS---------VAHV-TADPDLTLVSGITS-TDGFFKQFAYAELER 351
11_pfamImport 236 FdsVFTLTstIRLVMINVLLISMWEIVQALWDVYSTHP-----LDLSRF-DTEPNQCLLEGIRS-TDPRVQNYAIRELAH 308
XP_007406799  253 FnsIFTFTsnLRLVMLNWLMVSCWEVVQAFWEVYLTQP-----LAISHF-AEEPNRCLLEGLRS-VDMRIQYHAIVELAQ 325
XP_009268324  269 ---SFGLI--LRTMLFTISLTTTWEVANTLFDVYSVHP-----MLISKV-SPASNDCLLDGLGC-EDTYYRHLAYLEFVM 336
XP_024512721  269 G--PWALL--GPMLTLNMLTLLALQFPVKGLAAYTTQP-IhfdEFYKKS-PLSLEIYLITALKS-QDPYYLQFTLMELLR 341 Cryptococcus n...
XP_015210884  326 LSQNSP----SRRQEVFSLSQPGGhPhNWTAISGECLGLLSDLTRRLVayheavasngrvkqqsagsdkkssssssssss 401
XP_012188578  337 LSAGDK----EMRGLIYRDVGGDV-T-AWMQIRDRCLGLLEESRLFVVrrgqvatkpqasmpstsqpqqqktsakppq-- 408
XP_011392699  337 LSAEDK----DIRRSIYNDVGGDV-T-AWMQIRDRCIRLLEESKVFVErrgqlssstpprtqpssqqtveiqqqnns--- 407
XP_007397684  365 FARDEThagsTRRVALFTDQKYNP-N-LWSAFAREALLTLGRDYQLLLrrgappaaapapappakkldappqipktpfik 442
EMD32361      368 LACDESpsgsARRTELFADQKYNP-S-LWATLAREALLILGRDYQLLLrkgqpeipapapppppaqakpplpaqpiqiir 445
EPS94314      352 CASDDSasarSRREALFADQKYNP-N-LWASLCRESLLTIGKDYQLFLrrgqpvsaaptpappkiatplpakptqlirg- 428
11_pfamImport 309 ISWSDP----ARRSTIFKDIRASP-R-LLNLIIEECLNIIDTTRATIEsggqpiqkisaaqtsvgphrpspgthsav--- 379
XP_007406799  326 ISWSDP----ARRVTIFQDIRTQR-K-IFNAIVEECLSVISATQRMVIsrgempppvesigtqamstplntktsdhgrp- 398
XP_009268324  337 VFSTDK----QRRLSVYGDINRNP-T-SWDKYLGLAVKEMSDGRNKVLsrgatsdaaidkpfhhlntpstatstatsssg 410
XP_024512721  342 VVSIP-----RHRKIFFDDISKSP-S-LISQLCQELLLQFGKVHNVLVnrgvtiqpqntksspvaasgistahderkis- 413 Cryptococcus n...
XP_015210884  402 sepsglgelagwpvqtpragaglrtpgsvlarsslgglrspltapFTPDLGSpfgSPAIQrfartldpaspwygsvqsph 481
XP_012188578  409 ----------------tiwdqlaagqtapkdstppstsspatapsTSTTVSTppqQQPAPllsiqslsktslnlitlawk 472
XP_011392699  408 ----------------akprptiwdqlaagqtppkesvasattpaPATNSASkpgPSASAllsvhsvskaavslatliwk 471
XP_007397684  443 ---------------------------epvlkqksasplhsaletiasdgsvtaalasTAeagas------------qip 483
EMD32361      446 ---------------------------gpvlkaspssplrnaldtiasdgalpaavssTAeaah--------------lp 484
EPS94314      429 ----------------------------pilkgtpasplraaldtlasdgplstavgtTAdgaas------------hip 468
11_pfamImport 380 ----------------ktdlpqlfntsshpnsmkqvflrkllsseSGQEPTApgsTTFQPsatslkkektesdyqipdif 443
XP_007406799  399 --------------alvkdlpqlfnaqpqsdslkktllsklltspAETGSETtstPSIPTvqptsng---------yqmp 455
XP_009268324  411 khlrvlqdekiyqrpprntfestvdqsqspkstpssllkdapkplAKGTQd----------------------------- 461
XP_024512721  414 ---------------irqadifrplakpkstfnlksildgpiqatA---------PSPVVklg----------------q 453 Cryptococcus n...
XP_015210884  482 vmRRGPKLWTSSTDTLANgsp-----avSPAPEPRA-------------------------------------------- 512
XP_012188578  473 llPSDAKHVLFGARRQQT-------------------------------------------------------------- 490
XP_011392699  472 llPADAKHVVFGPRRQQM-------------------------------------------------------------- 489
XP_007397684  484 elFRSVLPSQTKAV--------------AETAGAAVetvkkgeqeimqlaalpgkwkgrlqqelva-qspsavrraaarl 548
EMD32361      485 elFRSVLHT-------------------DTAAQTAVatlrkkeedvkglvqrthnrwrdalaafaedglpkgvleavtev 545
EPS94314      469 elFRS-----------------------VRPAAKAVeavqkgeervvglieqtrskwrqrfdgvvrsrapeaafaavrev 525
11_pfamImport 444 lrDQSRKLASKSTSDLSTgdnlkpspspQSSTKALQsstpqkrekivpkiwki--------------------------- 496
XP_007406799  456 eifQSPRKLDRSIADTKS----------KSSSLALPpstpkke------------------------------------- 488
XP_009268324      --------------------------------------------------------------------------------    
XP_024512721  454 agTLAIKHVESVQDRVVGriegnpvggaIVSEAKGArkgv---------------------------------------- 493 Cryptococcus n...
XP_015210884  513 ----------------SPaehkpsffslwlqnrreqvktflakrvlVMYLFNKLPEASSQALF-----A-DSQAHIWA-- 568
XP_012188578  491 -------------------------------------------------LLGESPSSLASSVI-----ArDAHRTICA-- 514
XP_011392699  490 -------------------------------------------------LLGESPASQASSIV-----ArDAHRTICA-- 513
XP_007397684  549 erwwhrervhkvveaaLP-------------------------------------NRKLDGLA----------------- 574
EMD32361      546 rgwwsrervhkrveasLP-------------------------------------NRQLDVLV----------------- 571
EPS94314      526 rewwtrerlnrkvemcLP-------------------------------------NRRLDALV----------------- 551
11_pfamImport 497 ------------------------------flhspllksseagsrlEDWLFSPSMTDELEKCL-----S-KRQLCMFS-- 538
XP_007406799  489 ----------mikaesFSrtqkiipkgwemvrkirgvgsserirslENWLFLPSVRMELRRTL-----D-NHRACALA-- 550
XP_009268324  462 ----------------------------------------------AVIGFDKLLPKDLLRMLrkilnG-NEQAVVNAki 494
XP_024512721  494 -------------newAG---------------------------------KEWGRRSVRSVL-----G-EVLVAQRV-- 519 Cryptococcus n...
XP_015210884  569 -------------LEGLSNLVAASYTEDRFGVVQTTFPNILSTMLTLLEAVDKH------------F------------K 611
XP_012188578  515 -------------ALTLKSLLCQSLTEDPYGTVSKDIKRILTAFVGLDSEIRTLgmq------leaQareiddklerveA 575
XP_011392699  514 -------------ILTLKALLCHSLDEDAYGSVSKDIQRILSEMVDLELQIRSLgmq------lerQameids-klqklV 573
XP_007397684  575 -------------ADALCSLVCASLTEDRYGVVQRDIPRILEALLSFLGAVEDYqseii--tkypvPspeemgqlnakeA 639
EMD32361      572 -------------VDVLSAFVCASLAEDQYGVVQRDIPKILEALLSFLQAVEDYqaevn--amytpPsqeefanlspkeI 636
EPS94314      552 -------------IAVLCHLVCRSLTEDRYGVVQRDIPKILEALLSFLTAIEEYqsein--klhvpLtpddiqqlpvkeL 616
11_pfamImport 539 -------------VEAVTNFTCASLTEDQYGVLQDQIPRIMESLVDCFDALDRLrintcaefgvqpPp----------vQ 595
XP_007406799  551 -------------VEAVTNLMCASLTEDQYGVAQDQIPRVMECLIECLETVKAFslticdeygatsNhqdqndddqtdnG 617
XP_009268324  495 klmapemklvslsALGLAYLGAASINEDQYGLIQHSIPHVIAQLTETLIVYERF-------------------------- 548
XP_024512721  520 -------------IEILVILSIASIEEDTYGNVQQVLPAILEAIVRFREAIFALevq------llaQtr---------lL 571 Cryptococcus n...
XP_015210884  612 LPHASSKPVQSsgsledTtyktlRFALRASLKTAIYRITVTFGEHLNAVEVSAEHRKRLQ 671
XP_012188578  576 DGDGQSKQGEGr----------------GEVQDELKRVWTAGGAGQLDLYLVAS-MREIL 618
XP_011392699  574 DQVTHAQGDKAkqheawA----------SHVQLELSQAWAKRGARDMDLSLIAA-MRQIL 622
XP_007397684  640 AEMQELALDLAra--gdA-----LSEMTDPLKDSIVRIVRTFGDKLSAFKFPPRTARKLQ 692
EMD32361      637 VQKDILAMEVAra--seT-----LSEASDALKDGVVHIVRTFGDKLTAFKFPPRTARKLQ 689
EPS94314      617 AQRERVALEVAra--geV-----LSEVNDAIKIGVGQIARTFGDKLAAFKFPPRIAYKLQ 669
11_pfamImport 596 ATAPASSELDPvqihfhLtldehLHPLLTRLKAGIFGITDQFKPFLKEMSFSPKIDQWIQ 655
XP_007406799  618 AKRIRDAEl-------rEsmdefVTPLLTRLNDGSVGILNQFGPYLKEWSFSPKTDKWIQ 670
XP_009268324  549 -----QSELLKstthihE-----FNTRMQELRNALSVILVAFKDYIATFNLDEQVSGRVD 598
XP_024512721  572 GPAQSGAMDEVk----kD-----LYVAIGSCDKAVKRIADTFGQSLSSFRFPPSVAYGLG 622 Cryptococcus neoformans var. neofo...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap