Conserved Protein Domain Family
Ndc1_Nup

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pfam09531: Ndc1_Nup 
Nucleoporin protein Ndc1-Nup
Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.
Statistics
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PSSM-Id: 401470
View PSSM: pfam09531
Aligned: 119 rows
Threshold Bit Score: 181.008
Threshold Setting Gi: 198423796
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015210884  13 KVICWRAAASiAWSVLLLPVITALFVFLsHLDLfhpvqwisdslsv-----lggsyvifsvvlLCLvvLVVGFFDLQYYT 87  spotted gar
EGN94543      41 SVLGNRL----LYNIFAYSALFSFTLSVlfigngdaslglltr------lvrsgtwavaattwVVGv-LPVAVLRKVYLT 109 Serpula lacryma...
XP_007397684  38 nVLRQRL----LSRTFLYSALFCWTLVIltatagrggvarlglvgalispffprtlglafiiwISGv-VPVLVLRKVYLT 112 Phanerochaete c...
EMD32361      45 AALRHRL----LYHIFAPSFLVSWLLVTiwsvwmqgglsglglggflsaplspwtlsfaavfwCLGv-VPVVVVRKNYLT 119 Gelatoporia sub...
EPS94314      29 svigRRL----FYNILAPSLAYSWVLANvwskwsqggpsqlglwgsfvdcikpltllhavaiwMLGv-VPALVLRNRFLT 103 Fomitopsis pini...
XP_012188578  24 ALRPRQTRAFvLAAVAWHLFLTSALLSTlSLSLispltl------------------aasllsFGLgvLPLLAKRKRSLS 85  Pseudozyma hube...
XP_011392699  24 ALRPRQTRAFiLSAVAWHLLLTSALLSTaSLSLmspltl------------------gvsllsFAVgvLPLLAKRKRKLS 85  Ustilago maydis...
XP_003889770  24 vILRRRTYHF-----CLISYLLSNIVlwfvmldglpalwn----------glrittwimgganWASatIPLMTLRRLQLT 88  Puccinia gramin...
EGG09745      18 vVLRRRACHF-----CVITFLTNLGLlwvsmldgspavwn----------flrvpfwimggavWASvtIPMMMLRRSQRQ 82  Melampsora lari...
XP_009268324  35 LVLRKRMIRLvLLTFLSTCTIFSVSTSNlNDRIsstislnr---------------flfaavaFSLsvIPIIITRKla-- 97  Wallemia ichthy...
XP_015210884  88 VVPSI----PCTK--IAL----IGKVLHPQQFIHSLAHCLMGLLvswCAAVMIGgrYhvfakpchsEES----------- 146 spotted gar
EGN94543     110 GASPP----ATSP--SKI----LQNALGKPSTLRSLSVYVTSAI---FLAVMHVtlAklee-tsgqGDRrlsvf-vksrk 174 Serpula lacryma...
XP_007397684 113 ASPAS----ASSP--SGV----FRDALNKSSTFRSLAVYLTSAS---LLTAIHVvtAlvfd-vragRDPrlslf-vksrk 177 Phanerochaete c...
EMD32361     120 VTPTA----SLSP--STV----FQSTLTKTSTPPALLAYLCSST---LVTFMYIfmTyvyg-ssssEDRhlsff-vkskk 184 Gelatoporia sub...
EPS94314     104 ATPTS----ASSP--SKM----FSAALVKRSTTCALVTYLASGV---ALAVVHMflAniye-pspsGHPrfslf-vksrk 168 Fomitopsis pini...
XP_012188578  86 QITTPparlPSSK--AQQ----LSAALSDPTLVTLIFQHVVAFV---VLALGYAalLtyrkggwa-------pqiwvesh 149 Pseudozyma hube...
XP_011392699  86 QITTPparlAPSK--AQQ----LSSALTDPALLPLVYQHVAAFV---VLALGYAalLtyrsggwa-------pqvwvesh 149 Ustilago maydis...
XP_003889770  89 ASSLY----APNR--YAK----FWAVLKSTEFITSTLFCSISGS---LLCLTYV--Saal---alnENPelglfksvpgr 150 Puccinia gramin...
EGG09745      83 KRPSS----CLTR--YQS----IVAVLGSAQHLAACVLLSISSL---LLWTCYV--Aaan---alnEEPdlklfktmpgr 144 Melampsora lari...
XP_009268324  98 -------liTKPPpsPSSpsqrIKSFLLNNKTYSSTSVYALSAV---IYAISFL--Acvs---theEDAqftpf-tthkr 161 Wallemia ichthy...
XP_015210884 147 HQMCLNEYHLFFLLAGAFMGYSY-----------SLLSVVKNMNYV-------SFQTIQQYKYLrFKGtLPVVIKHSA-V 207 spotted gar
EGN94543     175 HPYYLNGRFIFLMCSQAWLAGTF-----------FLRNIMLDRFVFrf---slGSPTTHSRRWL--FS-VGDLMKLLLtI 237 Serpula lacryma...
XP_007397684 178 HPYYLNGRLLYLISSQISLAAFY-----------VLRNVMMDRLAVrw---tgSMSARAMNEIP-SFM-LARILTVTAsA 241 Phanerochaete c...
EMD32361     185 HPYYLNGRVLYLISSQMVISAAY-----------FFRNALLDRFVVhw---teLSTTTNPVQAR-TVR-LAQLLTMLVtV 248 Gelatoporia sub...
EPS94314     169 HPYYLNGRVLYMLFSQAVLASAY-----------LLRTVLLDRFAVrw---tqVPSQPDAPERH-PFR-LARIVGTLItI 232 Fomitopsis pini...
XP_012188578 150 ASFYLNERFLYLVGQSIVLGAVYafvsrslpspqAVASPSFDASTLtt---dtPVTIKHRVVAA-FTArLPRAALVAAlT 225 Pseudozyma hube...
XP_011392699 150 GSLYLNERFLYLIGQSILLGTVYafllrglpspeSVASPLFDPSTLts---dtAVTIKDRVASA-FSTrLPRAASVAAlT 225 Ustilago maydis...
XP_003889770 151 GVTQISERPIFLLASCWYTALCY-----------SFSAIYHGKWHYrp---fdVSEHLTIPQRI-WNS-LDSRIEFVRrS 214 Puccinia gramin...
EGG09745     145 GASQINERPIYLAASALFCAFYY-----------SFLLTYEQRFPSkr---adQPEGLMISQRI-LRT-LPTVFTRANrF 208 Melampsora lari...
XP_009268324 162 RGWQFNERFIFFILNAIVLAISY-----------SIYQLWTDRFITrfpsnisQSISERVLTHL-KRN-LASGVKFSIiT 228 Wallemia ichthy...
XP_015210884 208 QSLYSV-RNYCITyLFLgyiPRAWICTT--M-----------NLSRDSTLhaldTLAGllDFSLM--FHLWITGTFLLVM 271 spotted gar
EGN94543     238 SLFVTLsFGLYGVaFGL---ARSIILPIlfKipilh--hllrPFTAHFLRgswtLLMPlrNFSLV--LRTLSLGMITLVN 310 Serpula lacryma...
XP_007397684 242 LLLTAMgTVAHIVlFGC---ARAIVIPFvfKlpvls--hllrPFLAHFLRgpfaLTLLtrHTGLI--FRAFMLGFLTIST 314 Phanerochaete c...
EMD32361     249 GIFSGLcVAGHTLlFGL---ARSIALPVvfRipivs--rflrPFMAHFLRgrftLTLLarHWSLI--TRTFYLGITTLAG 321 Gelatoporia sub...
EPS94314     233 GLSVSLtTVAYATlFGC---VRSLVLPTvyAlpyip--qflrPFTAHFLRgpwtVTLLlrNWSLV--WRTFFLGVTTAAC 305 Fomitopsis pini...
XP_012188578 226 SSASILv-------YSI---VRIRMWStillv------lgtrGVMRRLLVpsfrVEFAffEVS----VRSVLFSIAATCA 285 Pseudozyma hube...
XP_011392699 226 SSTSILi-------YSI---MRIRMWSailmv------lgtrGMMRRLFVpsfrVDFAyvEVS----LRTVLFSVAAVCA 285 Ustilago maydis...
XP_003889770 215 IIYCSAtFLPi---YLI---SRRYLIRaivf-------skytQLTKHIKPhmvmLIKFdsVFTLTstIRLVMINVLLISM 281 Puccinia gramin...
EGG09745     209 SFLCSApFLPf---YLI---CRRYLIRaivf-------skyvQLTKFIKPhlvmMIKFnsIFTFTsnLRLVMLNWLMVSC 275 Melampsora lari...
XP_009268324 229 VLTCLSs-------YFL---LKKPIYRTlaTfslstfrphlfSLLRQNNL----------SFGLI--LRTMLFTISLTTT 286 Wallemia ichthy...
XP_015210884 272 WYITWLLFRIYITEMYwFPVQSTfSENASQCLPKVLTGqQPPILKFLALQDLALLSQNSP----SRRQEVFSLSQPGGhP 347 spotted gar
EGN94543     311 WEFAEALFDVYIPQP--IKTAQT-TADPSVTLISGISS-QDPIFRQYAYSELIDLALEDSpmasERRTTLFGDQKYNP-S 385 Serpula lacryma...
XP_007397684 315 WDFAENLFDTFVAEP--INVAQA-TADPAVTLVSGTTS-QDLYYKHFAFAELAQFARDEThagsTRRVALFTDQKYNP-N 389 Phanerochaete c...
EMD32361     322 WEFAESAFDEAVS------VSHH-TGAPTHILVSGTTT-ADAYYKHFAYSELRELACDESpsgsARRTELFADQKYNP-S 392 Gelatoporia sub...
EPS94314     306 WELAESPLDEPVS------VAHV-TADPDLTLVSGITS-TDGFFKQFAYAELERCASDDSasarSRREALFADQKYNP-N 376 Fomitopsis pini...
XP_012188578 286 VETAYLLLDVYLSHPL-PPVSKY-AKFPNRLLLDGIEE-PVLFFSNHAFSELARLSAGDK----EMRGLIYRDVGGDV-T 357 Pseudozyma hube...
XP_011392699 286 VETAYLLLDVYLTHPL-PAVSKH-TKFPNRLLLDGIHE-PTLFFSNHAFSELARLSAEDK----DIRRSIYNDVGGDV-T 357 Ustilago maydis...
XP_003889770 282 WEIVQALWDVYSTHP--LDLSRF-DTEPNQCLLEGIRS-TDPRVQNYAIRELAHISWSDP----ARRSTIFKDIRASP-R 352 Puccinia gramin...
EGG09745     276 WEVVQAFWEVYLTQP--LAISHF-AEEPNRCLLEGLRS-VDMRIQYHAIVELAQISWSDP----ARRVTIFQDIRTQR-K 346 Melampsora lari...
XP_009268324 287 WEVANTLFDVYSVHP--MLISKV-SPASNDCLLDGLGC-EDTYYRHLAYLEFVMVFSTDK----QRRLSVYGDINRNP-T 357 Wallemia ichthy...
XP_015210884 348 hNWTAISGECLGLLSDLTRRLVAYHE--------------------------------AVASNGRVKQQSAGSDKKssss 395 spotted gar
EGN94543     386 -LWSSLAREALLALGRDYQLLLRRGKpvpvva------------------------------pseskpVTKTPQAPstpl 434 Serpula lacryma...
XP_007397684 390 -LWSAFAREALLTLGRDYQLLLRRGAppaaapap----------------------appakkldAPPQIPKTPf------ 440 Phanerochaete c...
EMD32361     393 -LWATLAREALLILGRDYQLLLRKGQpeipapap------------------------ppppaqakPPLPAQPiq----i 443 Gelatoporia sub...
EPS94314     377 -LWASLCRESLLTIGKDYQLFLRRGQpvsaaptp--------------------------appkiatpLPAKPtq----l 425 Fomitopsis pini...
XP_012188578 358 -AWMQIRDRCLGLLEESRLFVVRRGQvat--------------------------kpqASMPSTSQPQQQKTSAKPpqti 410 Pseudozyma hube...
XP_011392699 358 -AWMQIRDRCIRLLEESKVFVERRGQlssst----------------------pprtqPSSQQTVEIQQQNNSAKPrpti 414 Ustilago maydis...
XP_003889770 353 -LLNLIIEECLNIIDTTRATIESGGQpiqkisaaqtsvgphr--------------------------------pspgth 399 Puccinia gramin...
EGG09745     347 -IFNAIVEECLSVISATQRMVISRGEmpppvesigtqamstplntktsdhgrpalvkdLPQ------------------- 406 Melampsora lari...
XP_009268324 358 -SWDKYLGLAVKEMSDGRNKVLSRGAtsdaai--------------------dkpfhhLNTPSTATSTATSSSGKHlrvl 416 Wallemia ichthy...
XP_015210884 396 sSSssssepSGLGelagwpvqtprAGAGLRTPGSvlARSSLGGLRSPLTAPFTPDLGSpfgspaiqrfartldpaspwyg 475 spotted gar
EGN94543     435 iRQ------PIFKasr-----qspLTSVLDSFAS--DSKLAEAVEItaeasksnvpelfrsvmhvpastpqsqkpsttsa 501 Serpula lacryma...
XP_007397684 441 iKE------PVLKqks-----aspLHSALETIAS--DGSVTAALAStaeagasqipelfrsvlpsqtkavaetagaavet 507 Phanerochaete c...
EMD32361     444 iRG------PVLKasp-----sspLRNALDTIAS--DGALPAAVSStaeaahlpelfrsvlhtdtaaqtavatlrkkeed 510 Gelatoporia sub...
EPS94314     426 iRG------PILKgtp-----aspLRAALDTLAS--DGPLSTAVGTtadgaashipelfrsvrpaakaveavqkgeervv 492 Fomitopsis pini...
XP_012188578 411 wDQ----------------------LAAGQTAPK--DSTPPSTSSPATAPSTSTTVSTppqqqpapllsiqslsktslnl 466 Pseudozyma hube...
XP_011392699 415 wDQ----------------------LAAGQTPPK--E-----SVASATTPAPATNSASkpgpsasallsvhsvskaavsl 465 Ustilago maydis...
XP_003889770 400 savktdlpqLFN-----------------TSSHP--NSMKQVFLRKLLSSESGQEPTApgsttfqpsatslkkektesdy 460 Puccinia gramin...
EGG09745     407 ---------LFN-----------------AQPQS--DSLKKTLLSKLLTSPAETGSETtstpsiptvqptsngyqmpeif 458 Melampsora lari...
XP_009268324 417 qDEk-----IYQRppr-----ntfESTVDQSQSP--KSTPSSLLKDAPKPLAKGTQd----------------------- 461 Wallemia ichthy...
XP_015210884 476 svqsphvmrrgpklwtsstdtla--------ngspavspapeprvspaehkpsffslwlqnrreqvktflakrvlVMYLF 547 spotted gar
EGN94543     502 tviavtqpvsvgn------------------------gliarikgkgkeaiieycphkikqvvgsciewwgrerinkvve 557 Serpula lacryma...
XP_007397684 508 vkkgeqeimqlaa-------------------------lpgkwkgrlqqelvaqspsavrraaarlerwwhrervhkvve 562 Phanerochaete c...
EMD32361     511 vkglvqrthn-------------------------------rwrdalaafaedglpkgvleavtevrgwwsrervhkrve 559 Gelatoporia sub...
EPS94314     493 glieqtrsk---------------------------------wrqrfdgvvrsrapeaafaavrevrewwtrerlnrkve 539 Fomitopsis pini...
XP_012188578 467 i------------------------------------------------------tlawkllpsdakhvlfgarrqqtLL 492 Pseudozyma hube...
XP_011392699 466 a------------------------------------------------------tliwkllpadakhvvfgprrqqmLL 491 Ustilago maydis...
XP_003889770 461 qipdiflrdqsrklaskstsdlstgdnlkpspspqsstkalqsstpqkrekivpkiwkiflhspllksseagsrlEDWLF 540 Puccinia gramin...
EGG09745     459 qsprkldrsiadtkskssslal---------ppstpkkemikaesfsrtqkiipkgwemvrkirgvgsserirslENWLF 529 Melampsora lari...
XP_009268324 462 ---------------------------------------------------------------------------AVIGF 466 Wallemia ichthy...
XP_015210884 548 NKLPEASSQALF-----A-DSQAHIWA---------------LEGLSNLVAASYTEDRFGVVQTTFPNILSTMLTLLEAV 606 spotted gar
EGN94543     558 aclpHRELDALV------------------------------VEVLSRMVCASLTEDRFGVVQRDIPRILEAFLSFLSAI 607 Serpula lacryma...
XP_007397684 563 aalpNRKLDGLA------------------------------ADALCSLVCASLTEDRYGVVQRDIPRILEALLSFLGAV 612 Phanerochaete c...
EMD32361     560 aslpNRQLDVLV------------------------------VDVLSAFVCASLAEDQYGVVQRDIPKILEALLSFLQAV 609 Gelatoporia sub...
EPS94314     540 mclpNRRLDALV------------------------------IAVLCHLVCRSLTEDRYGVVQRDIPKILEALLSFLTAI 589 Fomitopsis pini...
XP_012188578 493 GESPSSLASSVI-----ArDAHRTICA---------------ALTLKSLLCQSLTEDPYGTVSKDIKRILTAFVGLDSEI 552 Pseudozyma hube...
XP_011392699 492 GESPASQASSIV-----ArDAHRTICA---------------ILTLKALLCHSLDEDAYGSVSKDIQRILSEMVDLELQI 551 Ustilago maydis...
XP_003889770 541 SPSMTDELEKCL-----S-KRQLCMFS---------------VEAVTNFTCASLTEDQYGVLQDQIPRIMESLVDCFDAL 599 Puccinia gramin...
EGG09745     530 LPSVRMELRRTL-----D-NHRACALA---------------VEAVTNLMCASLTEDQYGVAQDQIPRVMECLIECLETV 588 Melampsora lari...
XP_009268324 467 DKLLPKDLLRMLrkilnG-NEQAVVNAkiklmapemklvslsALGLAYLGAASINEDQYGLIQHSIPHVIAQLTETLIVY 545 Wallemia ichthy...
XP_015210884 607 DKH------------F------------KLPHAsskpvqssgsledttyktlRFALRASLKTAIYRITVTFGEHLNAVEV 662 spotted gar
EGN94543     608 EEYhqevn--alytpPspeelsklsaqeLGEKErkriev-------araaevFGVVGDALKAAVARIALTFGDKLLAFKF 678 Serpula lacryma...
XP_007397684 613 EDYqseii--tkypvPspeemgqlnakeAAEMQelaldl-------aragdaLSEMTDPLKDSIVRIVRTFGDKLSAFKF 683 Phanerochaete c...
EMD32361     610 EDYqaevn--amytpPsqeefanlspkeIVQKDilamev-------arasetLSEASDALKDGVVHIVRTFGDKLTAFKF 680 Gelatoporia sub...
EPS94314     590 EEYqsein--klhvpLtpddiqqlpvkeLAQRErvalev-------aragevLSEVNDAIKIGVGQIARTFGDKLAAFKF 660 Fomitopsis pini...
XP_012188578 553 RTLgmq------leaQareiddklerveADGDGqskq----------------gegrGEVQDELKRVWTAGGAGQLDLYL 610 Pseudozyma hube...
XP_011392699 552 RSLgmq------lerQameids-klqklVDQVThaqgdka----------kqheawaSHVQLELSQAWAKRGARDMDLSL 614 Ustilago maydis...
XP_003889770 600 DRLrintcaefgvqpPp----------vQATAPasseldpvqihfhltldehLHPLLTRLKAGIFGITDQFKPFLKEMSF 669 Puccinia gramin...
EGG09745     589 KAFslticdeygatsNhqdqndddqtdnGAKRIrdaelr-------esmdefVTPLLTRLNDGSVGILNQFGPYLKEWSF 661 Melampsora lari...
XP_009268324 546 ERFqsellks------------------------------------tthiheFNTRMQELRNALSVILVAFKDYIATFNL 589 Wallemia ichthy...
XP_015210884 663 SAEHR 667 spotted gar
EGN94543     679 PPRTA 683 Serpula lacrymans var. lacrymans S7.3
XP_007397684 684 PPRTA 688 Phanerochaete carnosa HHB-10118-sp
EMD32361     681 PPRTA 685 Gelatoporia subvermispora B
EPS94314     661 PPRIA 665 Fomitopsis pinicola FP-58527 SS1
XP_012188578 611 VAS-M 614 Pseudozyma hubeiensis SY62
XP_011392699 615 IAA-M 618 Ustilago maydis 521
XP_003889770 670 SPKid 674 Puccinia graminis f. sp. tritici CRL 75-36-700-3
EGG09745     662 Spktd 666 Melampsora larici-populina 98AG31
XP_009268324 590 DEQVs 594 Wallemia ichthyophaga EXF-994
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