4TKR,4MES


Conserved Protein Domain Family
Thia_YuaJ

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pfam09515: Thia_YuaJ 
Thiamine transporter protein (Thia_YuaJ)
Members of this protein family have been assigned as thiamine transporters by a phylogenetic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.
Statistics
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PSSM-Id: 401461
View PSSM: pfam09515
Aligned: 30 rows
Threshold Bit Score: 132.721
Threshold Setting Gi: 118133455
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4TKR_A           37 LLECAIFAAVAMVLSFIPLDIG-SSFSISL-GMIPMYVIAIRRGFWAAGFAGLLWGLLHFLtgKaYILMPSQAIIEYILA 114
jgi:Hore_10030    9 IVEAGMAVALSAVFNLIPLWRMpQGGSISL-EMLPVLIIAFRWGGTPGLITGFVYGLVQLAidP-HIYYPLQVILDYPLA 86  Halothermoth...
tigr:NT01CX1441  31 MVTIAMFSAISFVLYLIEFIKFpQGGGITLfSMLPTMLLSILYGNTLGLTSGILFGLLKLLngA-TIVNPAQFLLDYIFA 109 Clostridium ...
jgi:Clos_0240    43 IVYGSLCIALSFVLSYIRLYRFpQGGSITPaSMLPIYIFAIMFGPTAGILAGFAFGMIQLIqdP-YIIHWAQFFLDYPLS 121 Alkaliphilus...
WP_012065610     43 LVYGSLCIALSFVLSYIRLYRFpQGGSVTPaSMLPLFIYAVAFGPIPGIIAGFALGMLKLIqdP-FVIHWAQFFLDYPLA 121 Alkaliphilus...
Q8XKM2           60 LTTIGIALALTAVLNMLKIYKFpQGGGITLgSMIPIILIAYAYGPLVGMLTGFLFGIISLFidP-YILHPVQVLFDYPIP 138 Clostridium ...
Q899C9           46 ISSIGLALALAIILDMFKLTKLpNGGSVTLgAMVPIILISLLYGPEVGFLTGFLCGLIKLIlgP-YILHPLQVLFDYPLP 124 Clostridium ...
WP_012102375     43 VTQIGIALALATILKIFRIYHLpQGGSVTLgSMVPILLMALLYGPEVGFITGFLYGIITLIldP-YILHPIQVIFDYPLP 121 Clostridium ...
Q97F27           46 VAQVGVVLALSTVLSLFKIYKLpQGGSVTLgSMVPILLIAFFYGPEVGFLTGFLFGIIDLMleP-YLLHPIQVLFDYPLP 124 Clostridium ...
Q3AFI2            9 VTRGGLALALAVVLSFIKIWQMpQGGSVTLlSMLPVIYFAYTEGLLPGLLVGVLYGLLQYLieP-YFVHPVQFLLDYPVA 87  Carboxydothe...
4TKR_A          115 FSFIAFSGVFSKqvrsnlAANQLKKAIEWAWGTMIIGGVARYFWHYVAGVLFWGAYAFQGWGAQLFSIVMNGASCLGTVL 194
jgi:Hore_10030   87 YMLVGIAGYIPV------KNTGSKIPFIRIIGASLLGGLLRLFCHVLSGVLFFSQYAPEGQNVWVYSTVYNGTYLIPALL 160 Halothermoth...
tigr:NT01CX1441 110 TMALGLAGTFGN------DNK------IKIGLGSLMAVVLSVFVNVLSGAVYFGQYAPKGMNVWLYSFMYNISYAGVEGA 177 Clostridium ...
jgi:Clos_0240   122 FGALGLAGLYRK----------------NLGISCLIGGFGRFVMNFLSGVIFFGSYAPEGMNAFLYSLIVNGLVIGTDTL 185 Alkaliphilus...
WP_012065610    122 YGALGLAGLYRN----------------NLAVSVLIGGFGRFFMSFLSGVLFFASYAPEGMNPIIYSIVVNGLVLGTDTL 185 Alkaliphilus...
Q8XKM2          139 YMALGVAGFFKN----------------HRISGAVVAIFLKFLAHFISGVVFFGSFAPEGMSPILYSFLVNGSLIGADGL 202 Clostridium ...
Q899C9          125 FMALGLAGYFRN----------------NKILATIVAIFGRFVFHFIAGVIFWGSTAPETMSPYLYSLIYNGSFLSVNAL 188 Clostridium ...
WP_012102375    122 FMALGIAGYFRN----------------RKIVGTFLAILGRFICHFISGVIFFGSFAPKGMSPAIYSLTLNGIFIAVEGA 185 Clostridium ...
Q97F27          125 YMALGFAGYFKN----------------KKLLGTVTAVFIRFLFHVISGVVFFASSAPKGQSPLIYSIVYNGSFLSIDCI 188 Clostridium ...
Q3AFI2           88 FGALGLAGLFAK---------------KSPYPGVVLAILGRFLSHLISGVVFFASYAPKGQSPWVYSAIYNGSYLLPELI 152 Carboxydothe...
4TKR_A          195 VSGIIISILLKTSPKLFL 212
jgi:Hore_10030  161 LSMVLIIPLYRKLI-LYN 177 Halothermothrix orenii H 168
tigr:NT01CX1441 178 LCIIILLILPIKRLKINK 195 Clostridium novyi NT
jgi:Clos_0240   186 ICVIVSFVPQIQNAVKEV 203 Alkaliphilus oremlandii OhILAs
WP_012065610    186 ICVSFVFIPQIKSAVKHI 203 Alkaliphilus metalliredigens
Q8XKM2          203 ICVILLGILPVNRLIKAI 220 Clostridium perfringens
Q899C9          189 ICVVILYMLPVENLYKII 206 Clostridium tetani
WP_012102375    186 ICIAIMIVLPVKHLETII 203 Clostridium kluyveri
Q97F27          189 ICLVIIAIIPLKRLYTIS 206 Clostridium acetobutylicum
Q3AFI2          153 LTLGAVYLLKIFE-RLRK 169 Carboxydothermus hydrogenoformans Z-2901
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