Conserved Protein Domain Family
RNA_lig_T4_1

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pfam09511: RNA_lig_T4_1 
RNA ligase
Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i
Statistics
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PSSM-Id: 490428
Aligned: 120 rows
Threshold Bit Score: 84.982
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KIA3        188 LARGLFTEEVLEgdpvppleacsgqigsdpdapReRIVLRGYDKFFN-------------TGEVSWTEWDAMKQHT---- 250  Cryptococcus ...
Q54HU9         79 ECRGLIFNEATS-----------------------EIVCRKLHKFFN-------------INEQQETKEELIKLD----- 117  Dictyostelium...
XP_003291449   79 ECRGIIFEEKTG-----------------------KIVCRKLHKFFN-------------INELPETNQDDILLD----- 117 
XP_020436348   75 ECRGIIFDQSNG-----------------------KLLSRKFHKFFN-------------INELRETKAELIDLN----- 113 
Q54MC4         79 ECRGLIFDLKTE-----------------------KLLCRKLHKFFN-------------INEFKEVKAEFIDLN----- 117  Dictyostelium...
XP_003288189   76 ECRGLIFCKKTE-----------------------KLLVRKLHKFFN-------------INEYRECKADLVKLD----- 114 
XP_004361387   92 ECRGIIFDESNQ-----------------------QLICRKLHKFFN-------------INEYQECRAENVSLK----- 130 
XP_002673552   55 ECRGLVLELNS----------------------W-KIVARGMTRFFNqhhsyssspnirgLNDDRELVFLEQDQSPslek 111 
Q8B9G9         51 ECRGLILNSRT----------------------Y-AVVSRSFDRFFN-------------FQELLQNIGGEDAHHKlf-- 92   Rachiplusia o...
Q6R7G3         62 SCRGVCVEFDTEtg-----------------kpI-RKPIYSFNKFDN-------------------------RHNEpdfy 98   Ostreid herpe...
Q5KIA3        251 -----QGPYYLTLKSNGCLILIS-ALSPTHL---IVASKHSLgtttaaegvdlsgseklidkekpaqkcgdsalgpeisq 321  Cryptococcus ...
Q54HU9        118 ------ENFIVLEKLDGSLIAPI--LINGKA---AWGSKSGI-------------------------------------- 148  Dictyostelium...
XP_003291449  118 ------EEFILLEKLDGSLIAPI--NIDGSP---AWGSKAGI-------------------------------------- 148 
XP_020436348  114 ------QPFILTEKVDGSLIAPI--LVGGSV---LWGSKQGA-------------------------------------- 144 
Q54MC4        118 ------EPYILMDKIDGSLIAPM--LNKGQV---YWGSKQGI-------------------------------------- 148  Dictyostelium...
XP_003288189  115 ------GEYILMDKIDGSLISPMlIDNEGSVmgiYWGSKQGI-------------------------------------- 150 
XP_004361387  131 ------EPFTLTEKIDGSLIAPF--IVNGSI---SWGSKQGM-------------------------------------- 161 
XP_002673552  112 sklfdYSNFSLETKEDGTFLLMF--CYEGEW---MIATRHNF-------------------------------------- 148 
Q8B9G9         93 ---qsKENFKFYEKIDGSLIKIY--KYNGEW---HASTRGSA-------------------------------------- 126  Rachiplusia o...
Q6R7G3         99 nnlleCEAVVLANKFDGSFVRIWyDGVEEKF---VTATLGTL-------------------------------------- 137  Ostreid herpe...
Q5KIA3        322 irtipsfpptvgsldkhfkdltleqsqanqslsknalkkaekaalkyaqkvinegksedsaqitaaeekkeikeneEAQQ 401  Cryptococcus ...
Q54HU9            --------------------------------------------------------------------------------      Dictyostelium...
XP_003291449      --------------------------------------------------------------------------------     
XP_020436348      --------------------------------------------------------------------------------     
Q54MC4            --------------------------------------------------------------------------------      Dictyostelium...
XP_003288189      --------------------------------------------------------------------------------     
XP_004361387      --------------------------------------------------------------------------------     
XP_002673552  149 -----------------------------------------------------------------------------CED 151 
Q8B9G9        127 -----------------------------------------------------------------------------FAE 129  Rachiplusia o...
Q6R7G3        138 ----------------------------------------------------------------------------SADD 141  Ostreid herpe...
Q5KIA3        402 HAEVGRRWLKR---T---LESSGKTE-------------EELAQKLWEKNL-TAVLELCDDsfEEHVIATPEHWTGLHLH 461  Cryptococcus ...
Q54HU9        149 -TDLTI-KVEKhiqLkl--kDNNIRY-------------DDFALEWMLKGY-TPLFEWCSE--SNQIVLYY-AIDNLNLI 207  Dictyostelium...
XP_003291449  149 -TDLTT-RIEGhikKk---lEEETKY-------------DEFAKYCFEKGY-TPLFEWCSV--LNQIVLFY-PVDKLHLI 206 
XP_020436348  145 STDLAD-KIEDfiaRn----QEFYSY-------------NQFSLEWLNKDY-TPMFEYSSK--SQQIILFY-GEEKLSLI 202 
Q54MC4        149 -SDLGT-MLNDyvnRie--aIGLVKY-------------NDFSMKWIQLGY-TPLFEYSSS--KQQIILYY-GEERLRCL 207  Dictyostelium...
XP_003288189  151 -SDLGT-MLNDfivRvesNQSNQIKY-------------NEFSKKWLENGY-SPLFEFSSP--KQPIIIHY-KEEVLRLI 211 
XP_004361387  162 -TAFGK-RIDDfvnN-----NDSIRY-------------NDFAQYWLDRGY-TPVFEYSSD--KQQIILFY-QEERMRLL 217 
XP_002673552  152 YLAIGS--------------ETQKTYrelfveicggvelNEIGKD-LDPSL-TYCLEMCSS--QNEIVQIY-QNPVIYLL 212 
Q8B9G9        130 NLCVSDVTFKRlvlQalqLDEAHNQF-------------QALCNEYLDCAS-THMFELTSK--HNRIVTVYDEQPTLWYL 193  Rachiplusia o...
Q6R7G3        142 KFLVAETMMD-----------------------------QRIARHLKGNPYdCLLAELITP--KNIIVTDYNGKSFLTPL 190  Ostreid herpe...
Q5KIA3        462 GLNSNTP---------HFSTSS--PSDVATFAKEFG----FIQTKYIQLETLE--------------------------Q 500  Cryptococcus ...
Q54HU9        208 AMRNMKTg--------EYLTHD----EMVKITAPFNv----pVVTCVDLKSHThfsklyselngadksitttseefintG 271  Dictyostelium...
XP_003291449  207 AMRNMLTg--------DYLTHS----KMVEAAKPFNv----pVVECVDIKNHPqfvelykelss----ngadhdnlvktG 266 
XP_020436348  203 GIRDNVTg--------AYISYE----EMSKSATGFNv----pVIKRIDIANHPels--------------------likT 246 
Q54MC4        208 ALRNNHTg--------EYLKWK----ELQETCTAFNi----pMVDLIDTTSDQslfk-------------------sckS 252  Dictyostelium...
XP_003288189  212 AMRNIHTg--------EYLRWV----DLKKAADEFNi----pMVDLIDMKKDSkfe--------------------svkK 255 
XP_004361387  218 AIRDRTTg--------NYLQYD----EILKSGQEYGv----pVVERIKLESLLdpdld-----------------pnsiT 264 
XP_002673552  213 TIVETQSg--------KELSRDqvDKICLKLRKRAElknwKRPKRFENFSSLEqa----------------------lkH 262 
Q8B9G9        194 ASRNNETgdyfycsnlPFCKYPkcYEFT---------------------------------------------------S 222  Rachiplusia o...
Q6R7G3        191 SIVSHVD---------GLPRWStlRKVVPDMFMENGlpyyCRFTTIETLEN----------------------------D 233  Ostreid herpe...
Q5KIA3        501 VKSFTA--DLAQSGT-WEGE-----MIEGFVVRC-TVkngqdgmsqgappyranspfffkIKFEEPYL 559  Cryptococcus neoformans
Q54HU9        272 ASKLLK--IVLGLEN-----------CEGYILKF-DSgk--------------------tYKMKSNWY 305  Dictyostelium discoideum AX4
XP_003291449  267 AKRILE--LVQKIPQ-----------VEGYILKF-DSgr--------------------tYKLKTNWY 300 
XP_020436348  247 TTDLVH--AAKRMRN-----------VEGFVLKLeNTgh--------------------hYKVKTEWY 281 
Q54MC4        253 TIELVE--LVKQMKL-----------IEGCVLKFeNSgk--------------------mYKIKTEWY 287  Dictyostelium discoideum AX4
XP_003288189  256 TEDLVE--VVKGLKY-----------IEGCVLKFeDTgl--------------------mYKIKTSQY 290 
XP_004361387  265 TNELVN--IVKKMKN-----------VEGFVLRV-NDgr--------------------mYKIKSEWY 298 
XP_002673552  263 LDTFISthENVEARL----------RIEGFIMRDtNNq---------------------rLKLKNPFY 299 
Q8B9G9        223 VQECVE--HAAQLKN----------LEEGFVVYDkNNap--------------------lCKIKSDVY 258  Rachiplusia ou MNPV
Q6R7G3        234 LKEFEQ--------MtIDNPdvygrIPEGVCVYQcSLkdglvd------------vatpmSKIKRDEY 281  Ostreid herpesvirus 1 (is...
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