Conserved Protein Domain Family
Lact_bio_phlase

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pfam09508: Lact_bio_phlase 
Lacto-N-biose phosphorylase N-terminal TIM barrel domain
The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolism. The protein appears to be a carbohydrate-processing phosphorolytic enzyme (EC:2.4.1.211), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolism of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.
Statistics
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PSSM-Id: 490425
Aligned: 25 rows
Threshold Bit Score: 730.607
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015357751    7 GFFTLPGEAGYEDLTLELAEKWGADVIRDSDGTVLSPRILTSGYEIYSTLCLIRGVNDWAKAHRDKLQQNFLMSDPVIAS 86  Thermoclostrid...
WP_014759793    5 GRFTIPSESNFAEKTAELARLWGADAVRNSDGTQLDDEVVALGMKVYTAYFPTRAHNEWITLHMDETPQVYLLSKRALAE 84  Bifidobacteriu...
CDC71920       26 GRVTIPTDNNYFVETKRIAEKWGADAVRNCDGTHLPANASELAEKVYGTYFVVRGDNEWADSHPEELQNVLLMSERKTAR 105
WP_012858194    2 sRVTLPIEKGCEELVLELIKLWGADAIRNSDGTKLNDFFENLDAKIYSTYFPAREDQDWPRENPEEIQHQALISERYTAF 81  Streptobacillu...
CDB99194        6 GGFTLPGESGYEKLTLEMAEKWGADVIRDSDGTELSPEIINAGYGIYSTICIIRDHNEWAKQNTDKLQQSFLMTNPVVAE 85 
CDF45196        6 GGFTLPGEAGYEKLTLELADKWGADVIRDSDGTVLSDEITNAGYGIYSTICIIRDHNAWAKENQDKLQQTFLMTSPKVAT 85 
CDD64634        6 GGFTLPGESGYEKLTLKMAEKWGADVIRDSDGTVLSDEILNAGYGIYSTICIIRDHNEWAKKNMDKLQQTFLMTQPIVAD 85 
WP_013369533    7 GAFTLPGESGYEALTLKLAERWGADVIRDSDGTQLSDEIINAGYGIYSTICIIRDHNEWASRNLDKLQQCFLITNPKVAV 86  Paenibacillus ...
A9KHK4         10 GGFTLPGEAGFEKLTLELANRWGADVIRDSDGTELSDDILNAGYGIYSTICLIRDHNAWAKANIDKLQQTFLVTSPVVAN 89  Lachnoclostrid...
jgi:Oter_1377  12 GDFTLPGEAGYEQLTLRLAKKWGADTIRDSDGTQLSPEIVQAGYDIYSTVCLVRSVQPWARENRDKLQQNFLMSYPVVAE 91 
WP_015357751   87 ESTVTIDLLKGYFREQFEINCNDDPKKWWQVFDRTTGEEVPKDNWEFNRETGTVVIKNAKKWHKYTVNFLAYRIWEAISM 166 Thermoclostrid...
WP_014759793   85 SDTVDVSLMDGFFEEQLKPNFDADPHKYWEVVDRSTGAVVPTEQWTVDAEAGVVHVSGAELMHEYTVSFLAYIIWDPVEM 164 Bifidobacteriu...
CDC71920      106 DENLQIDLLEGYFDEQLKVNP-TDYRKYWQVFDRTTGQ--EHANWSY-DGNRMVTINDPIAFHEYTVNFFAYNMWDSTQM 181
WP_012858194   82 NDTLEIDPMEGYYKEQLEID--EKTTDYWQVFDRTTNSLVPKENWIF--DGNVVKIGNALKFHEYTVNFFAKQTWDTTHM 157 Streptobacillu...
CDB99194       86 CESVKIDLMKDFFNEQFKINESDESKAYWQVFDRTTNEEV--KDWTY--ENGVVTVNGVTPWHKYTVNFLAYRIWEEISM 161
CDF45196       86 ENTLYIGLMDDFFDEQFRVNDSEAAFKYWQVYDRTTDSVVSADKWSYNSADNSVELHDITPWHSYTVSFLAYRIWEEISM 165
CDD64634       86 CDTLTVELMKDFFAEQFSINETDDSLKYWQVYDRTTDTLVGREHWSY--ADGKVTIKEITPWHKYTVSFMAYRIWEEISM 163
WP_013369533   87 QDYVSIYLMEDFFAEQFKVNDSKEAFNYWQVFDRTTGEEVPREQWNYERESGNVVITGIVPWHKYTVSFMVYRIWEEISM 166 Paenibacillus ...
A9KHK4         90 SETLTIDLMEGFFKEQFLVNDSEEALEYWQVYDRTTETLLQKESWSYHPQNQTVVLTGICPWHKYTVSFMAYRIWEEISM 169 Lachnoclostrid...
jgi:Oter_1377  92 KATTAITLLKGYFTEQFVVNFKDNPKRWWQVFDRATGKEVPARKWSANEKKGIVTVTDTEPGHSYTVNFLVFRIWEEISM 171
WP_015357751  167 YNHITNNWGDREHLMPIDPIYPETQEFILSHLEKWLQEHPHTNVVRFTSMFYNFCWLWGDDPehfRYRYSDWGSYDFSVS 246 Thermoclostrid...
WP_014759793  165 YNHLTNGWGDKEHEIPFDIYHPATRKFVFDTFEQWLKDNPQVDVVRFTTFFYQFTLLFDQKQ---REKVVDWFGCACTVS 241 Bifidobacteriu...
CDC71920      182 YNYLTNDWNTEKHKV-FDPRYEQTHAHIESNLRSWLKRNDQVNVVRFTTFLYHFFLVFGDNK---KEKHVDWFGYPMSAS 257
WP_012858194  158 YNHMTNNWN-SDKSIPYDIVFDKTREHIYSHLKKWCDRNTNINVVRFTTFFYHFTIMYNQHA---MQKFGDWFGYSASVS 233 Streptobacillu...
CDB99194      162 YNHTTNNW-DKEHLMQIDPRYPETQQYMLDWMKNWCETHPATTVVRFTSMFYNFVWIWGSNEr-nRDLFSDWASYDFTVS 239
CDF45196      166 YNHTTNHW-DKEHLMQIDPVYPETQEYLKNWMENWCKEHPATTVVRFTSMFYNFVWIWGSSEr-nRQLYSDWASYDFTVS 243
CDD64634      164 YNHTTNNW-TKEHLMQIDPRHEATREYMLGWMRNWCETHPDTTVVRFTSMFYNFVWIWGSSEr-nRNLFSDWGSYDFTVS 241
WP_013369533  167 YNHTTNHW-DKEHLMQIDPMYTETQQYLLDWMEDWCLHHKETTVVRFTSLFYNFAWVWGSNEr-nRHLFSDWGSYDFTVS 244 Paenibacillus ...
A9KHK4        170 YNHTTNNW-NKEHLMQIDPIHKETQEYLLTWMDDWCKKHEQTTVVRFTSMFYNFVWMWGSNEk-nRYLFSDWASYDFTVS 247 Lachnoclostrid...
jgi:Oter_1377 172 YNHLTNDWGDREHLAAVDPMHPETQQVLLAFLEKWLREHPDTKVVRFTSMFYNFSWFWGADRatlRDVYSDWGDYEMTVS 251
WP_015357751  247 PYAMTKFEEKTGIKLTSEDFINKGLLNNTHNVPSPKIRAWMDFINEFVVTFGRKCVDLVHKYGKKAYVFYDDHWIGVEPY 326 Thermoclostrid...
WP_014759793  242 PTALDDFEKEYGYRLRPEDFVNEGSYNSAWRVPRKPQRDWIDFLSHFVRANVKKLASLSHEAGKEAMMFLGDQWIGTEPY 321 Bifidobacteriu...
CDC71920      258 PKAFEDFRNQYGYELKSEDIVDGGYYHNHFRLPTKAFSDYMEYTQKYVAKTISQLVDIVHQEGKEAMMFLGDSWIGAEPY 337
WP_012858194  234 PKMFEKFKEDKGYEITLEDIIDKGYYNNQFRNPSKVFLDYMDFMQKFVSTLAKVCVDIVHEYGKEAIMFVGDNWVGTEPY 313 Streptobacillu...
CDB99194      240 PLALKEFEKKYGYALTSEDFINKGELHATHMTCDKKKLDWMEFINDFVVDFGKKLVDLVHTYGKKAYVFYDDSWVGVEPW 319
CDF45196      244 PRALDEFAKVYGYQLTAEDFINQGKLHVTHMPGNQKKTDWINFINRFVIDFGKELIDIVHKYGKKAYVFYDDSWVGVEPY 323
CDD64634      242 PLALDEFAEKYGYSLTAEDFINQGKLHVTHMVGTRQKADWMAFVNDFVIWFGKQLVDIVHEYGKKAYVFYDDSWVGIEPY 321
WP_013369533  245 SRALDLFAKRYGYSMTADDFVNGGKYRVTHIPAEQRKLDWMAFINDFVIEFGKKLIDIVHRHDKLAYVFYDDSWVGMEPY 324 Paenibacillus ...
A9KHK4        248 PHALKLFEEEYGYVLTAEDFIHQGKFHVTHMPADKHKLDWMEFINNFVVDFGKKLIDIVHNYGKLAYVFYDDSWVGVEPY 327 Lachnoclostrid...
jgi:Oter_1377 252 PRALKLFEKRYGYRLTSEDFVNGGLYNSTHNAPSRRYRDYMEFIHDFVIEFGRKCIDLVHQHEKKAYVFYDDHWIGVEPS 331
WP_015357751  327 SPRFKDFNFDGIIKCVFNAFEARKCAGVTGVETHELRLHPYLFPtglkgePTFKEGG--NPTKDAKNFWMKVRRALLRAP 404 Thermoclostrid...
WP_014759793  322 KDGFEDLGLDAVVGSIGDGTTTRMIADIPGVKYTEGRFLPYFFP------DTFYEGN--DPSIEAWDNWRKARRAILRSP 393 Bifidobacteriu...
CDC71920      338 GKHFADIHLDSVVGSVGGGVTVRMLSEIPHVKYREGRMLPYFFT------DTFFDGNeeNALAELNKNWRNARRALMRKP 411
WP_012858194  314 GKYFKNIGLDGVAGSAECGVDIRMVSDMENIKIKEIRFLPYLFP------DTFYEGN--TPHLEWEYNWMRSRRAILTKK 385 Streptobacillu...
CDB99194      320 GKRFKDFGFDGLIKCVFNGFEARLCAGVDAVETHEIRLHPYLFPvglggaPTFMEGG--NPTLEAKGYWKNVRRALLRAP 397
CDF45196      324 KPEFKEFGFDGLIKCVFSGYEARLCAGVD-VDVHELRLHPYLFPvglgglPTFMEGG--NPTLDAKKYWNSVRRALLRAS 400
CDD64634      322 NGRFKEFGFDGLIKCVFSGYEARLCSGVD-VPTHELRLHPYLFPvglggaPTFMEGG--NPTLDAKKYWNSVRRALLRQP 398
WP_013369533  325 NDRFQEFGFDGLIKCVFSGYEARLCSGVK-VNTHEIRLHPYLFPvglgglPTFMEGG--DPTLDAKKYWINIRRALLREP 401 Paenibacillus ...
A9KHK4        328 HKNFEKFGFDGLIKCVFSGFEVRLCAGVK-VNTHELRLHPYLFPvglggaPTFMEGG--NPTLDAKNYWISVRRALLREP 404 Lachnoclostrid...
jgi:Oter_1377 332 SGRFGEFGFDGLIKCVFNAFEVRLCAHSKGVETHELRLHPYLFPtglkgePTFKDGG--NPTLDAKNFWIDARRGIVRAP 409
WP_015357751  405 VQRIGLGGYLHLVKDFPDFIDYIEELANEFRTLKSLHENDKPYTV 449 Thermoclostridium stercorarium
WP_014759793  394 IARMGYGGYLSLAAKFPKFVDAVEHISDEFRDIHDRTDGEAARGV 438 Bifidobacterium bifidum
CDC71920      412 LDRIGYGGYLSLAAKFPTFIDRVGEICEEFRTIYQTVDNKKPYCH 456
WP_012858194  386 VDRIGFGGYLSLAAKFPLFINSVTKSTNEFREIHEKTPNEECIKP 430 Streptobacillus moniliformis
CDB99194      398 IDRIGLGGYLSLTLPFPDFNDYIEKIADEFREIKEFHKAGKPYVL 442
CDF45196      401 IDRIGLGGYLHLVQDFPDFVDYIEKISDEFRALKDLHKAGKPYCC 445
CDD64634      399 VDRIGLGGYLHLVEPFPDFCDYIEKVSDEFRTVKSFHAQGAPLSI 443
WP_013369533  402 IDRIGLGGYLHLVEPYPDFCDYIEKIANEFREIKELHHEGKPYHI 446 Paenibacillus polymyxa
A9KHK4        405 IDRIGLGGYLHLVEDFPDFTDYIEKIANEFRRIKELHNAGKPMAL 449 Lachnoclostridium phytofermentans ISDg
jgi:Oter_1377 410 IDRIGLGGYLSLVEPFPDFQDYIEQLAKEFRLLKSFHASDRPWTA 454
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