Conserved Protein Domain Family
CDC27

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pfam09507: CDC27 
DNA polymerase subunit Cdc27
This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterised by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.
Statistics
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PSSM-Id: 490424
Aligned: 9 rows
Threshold Bit Score: 266.728
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011390219  20 KLITYRLLSRELRIHVDEAKQALAAFFDSHKDK---SQLDATYILIGRSAFRETQpdadkiardkdeqsegdklvgpssm 96 
Q6CE56        16 LSVSYAMLSRKFDIAPKQAREVLTEYVESNKSD---NSLHVTYCLRGVKRHGVST------------------------- 67  Yarrowia lipoly...
EDO32210      21 RIVTYKWLSRTLTVTANQAKQMLYAFLTAQQEKknkPQLSVTYLVGGRILQHGEMcs----------------------- 77 
P84798        19 KIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKEnsgAQLHVTYLVSGSLIQNGHSch----------------------- 75  domestic cattle
1_pfamImport   1 KIVTYKWLSLTLGVHVNTAKQMLYHYLDHKRKEs-sAQLHATYLVSGKFVDNGQTsh----------------------- 56 
Q7SAP2        17 KVVTYRLLSRALRVHPNVAKQMLYDFHKTQSSKk-pGTVYATYMLYGIKKSVQnqngnamdidlpssl------------ 83  Neurospora crassa
XP_001538907  18 EIVTHRALSRALKVHSNLAKRMLYEFHRLENSKk-pQSVNATYLISGTPALAQRHalngcakdgddeimqsspft----- 91 
Q2UB13        19 RTVTFRSLSRALRVHSTLAKQMLYDFHHNENNKk-pQSVNATYIITGVQKAPA-Patnghtngednrddvfpssp----- 91  Aspergillus oryzae
XP_756008     19 RTVTYRSLGRALKVHCNLAKRMLYEFHRTENKKk-pQSVNATYIITGIQRPSE-Katnsihaeshddgddimqgsp---- 92  Aspergillus fum...
XP_011390219  97 sssstaparsfldsrvtqrqtkanverqvIRLVSAADLEKARSSFEQISSCHIYSVSPGRLLdAAQLTAVQHDLHTQ-QK 175
Q6CE56        68 -----------------------------IELCDGSEIATKRSEFNEPVSQLIYSVSASPTT-TTILYNMALEASSMgPN 117 Yarrowia lipoly...
EDO32210      78 ----------------------------qYVLTTDDRLEETKSQFDPVTSVHIYSIQKQTLKdSNSLYMVDYDISRE-HK 128
P84798        76 ----------------------------kVAVVREDKLEAVKSKLAVTASVHVYSIQKAMLKdSGPLFNTDYDILKS-NL 126 domestic cattle
1_pfamImport  57 ----------------------------kVSVVREEQLEDFKAKMSLVVSVHVYSVQKALLKdSGPLYAVDYDAVKD-NL 107
Q7SAP2        84 --------------pdadpvddeevpsytLVLVQEERLADVLKEYETITSIHVYSVGPHPAKdLTLLVDAAQSALAI--- 146 Neurospora crassa
XP_001538907  92 ---------ssqaarqedgdgnddipttsITLVREEDLLEAKSRYQTVFSIFIYSVEPTRLQdLNVLGDIGHDIMQH--- 159
Q2UB13        92 ---------ylsssmpnqdsapdtvatasVLLVREEDLEGRAPLVSHA----GLDLQQTVLQdLNVLTDVSRETVSN--- 155 Aspergillus oryzae
XP_756008     93 ---------flpssmpnqdaasdevpttsIILAREEDLDGKCLRLARS------NLQPAVLQdLNVLTDVHREMLAA--- 154 Aspergillus fum...
XP_011390219 176 YVDSWQQTHRGAQLGViVNPNIKDNYdpskgiPSLGAPSGPALPVSKDS------------------KTANSSSSSSSSS 237
Q6CE56       118 KFAIVSELVEGVDLTP-TKPVIKDDS------PPVAAAASKPLITTAPAkkpaakqkpkldffggkkKEAKETTPAKHEK 190 Yarrowia lipoly...
EDO32210     129 HEDNRWSHIYCKEAARlGDGGESRAAag---rSALGKENSHPGLKTANGhskclsnil-icvlicieAGSSTTDVQKNKA 204
P84798       127 QNCSKFSAIQCAAAVPrAPAESSSSEkleqsdPPVSPEMQASDELTTNGhgpp----------vpkqSSQQPKGIMG-MF 195 domestic cattle
1_pfamImport 108 KNCSRYSAIRCASAVPmSSVELQQARe----vQQAPTPEPENKKAGMNGdtsp----------vlksSAKPPKGIMG-MF 172
Q7SAP2       147 -----KDDAKKPQPRPiVNSHVRRRErkglglKAAAPAKQESKTKTAPTkt---------------aPAKPSPAPAPAAA 206 Neurospora crassa
XP_001538907 160 --QPNDPLEYGKQYGMiLNRNVKRRSg-----lPPAPPAPDPVETVKKQkveka--------neapiTTKPEEPTQPQAK 224
Q2UB13       156 -HSQEDPLEYGGQWSMiQNKNVKRRTg----sRPPPAPAATKSKPTIPSkr---------------pS-EATSSQIKPEP 214 Aspergillus oryzae
XP_756008    155 -HAHEDPLEYGKQWGMiQNKDVKRRTg----vRPPPPAPTPAQEAAAPSkr---------------pSQDEATQKVKSES 214 Aspergillus fum...
XP_011390219 238 TVTSALGTRPLSTTTTIAKATTAAS-----SAPVGGRKSGLDWSRAKPKGSDSKPAAAKIKAQSSIQSVPDHktllgSDD 312
Q6CE56       191 KDDHKEAVKDVKKETTPIKEEKAAP-----VKEERKETKAPKGKSVLDAVKEGKKNEPKPKEPAPKSKKQLE-----AEE 260 Yarrowia lipoly...
EDO32210     205 PPQKSKKGQLPTMGMFAVKTEKKPEpkaepVKPPETKKQDKSNSGGMLSFFGKPTAGQSKKTEAKQEKIEKK-----SQE 279
P84798       196 ASKAASKAQDANKETKTEAKE-VMN-----SEKNNENLLLSGYWESMIVLFQAQCINKLKVNLDSEQEVKEE-----KKV 264 domestic cattle
1_pfamImport 173 ANKSAPKSQDNSKEMKPEKKEDAHD-----IEAPKSK--PVAKVNPVANFFGTQTSKKPEKTVKEEEAPQSS-----SRA 240
Q7SAP2       207 PAKPQEESKSTAPAMEPEAPTATTK-----KPAPSLKRNTSAASGIMQAFSKAASLPKKAKTSEKSTTAAEE-------- 273 Neurospora crassa
XP_001538907 225 TQTPQASSAASSRPSSGGNNKGGTS-----DKPSSLKR---DSSNIFKAFAKVKPKVKKDDVLERPSGREVE-----SAE 291
Q2UB13       215 KKEETAASEQASTRESTPSTASKPT-----EKAAPLKR---EKSNLFSSFAKAKPKQKKE-----ESATPAE-----SAE 276 Aspergillus oryzae
XP_756008    215 KKAEHAAMTSQTKAEEKPPVK--PS-----EKTAPLKR---EKSDLFSSFAKAKSKQKKDGS-ATPAVSGAE-----SAE 278 Aspergillus fum...
XP_011390219 313 EDEDDDDDEDDDKPaklgyadEDDHNQDVTKAelvrgt-------apqgtGKRADARSQTE------------------- 366
Q6CE56       261 AEKKRQRELEEALF-------ADEDEDFDIPV------------------KQPVKKEEPEK------------------- 296 Yarrowia lipoly...
EDO32210     280 QKPKKEKIHEKESAtsnekkeQEKERKKSEGKpkprsekekqptrkrvkkFESSDEEEDEQpiksksekksrkksndnkh 359
P84798       265 EQPPLSVT-EPKLAapv-dlkKSSKKAEPVRMqqkek--------krrkqMELSD-DETKEt------------------ 315 domestic cattle
1_pfamImport 241 AQQHERSKPEEKQEt-----vAPVEPQKDTKKdsrs----------ktkrLEDSDGEEE--------------------- 284
Q7SAP2       274 ----TPAALSDDGE-------DDDDVPLPKPD------------------------AQSTR------------------- 299 Neurospora crassa
XP_001538907 292 HSGPEDVVLDDAS--------EEEREDLFLDT--------------------GTRRSNSKR------------------- 324
Q2UB13       277 PSGAEDVFGDDDDA-------DEEPEELFPDS------------------GKSASSAAATR------------------- 312 Aspergillus oryzae
XP_756008    279 PSGAEDVVLGDASD-------EEEPEELFPDS--------------------GKSSTANNR------------------- 312 Aspergillus fum...
XP_011390219 367 ----AKEAAQ-RKELEAMMDTD--DEDN-DVQIVEPSGVSTSGNNTGQGKDld------pDVDMADSTVTDTMDgseaap 432
Q6CE56       297 ----ETIKEElQEDLEKAEKDT--LTDA-QMIAGGELDVTTEDVEMGDDDNg-------nKEDVEMTDVHMTNDgedvh- 361 Yarrowia lipoly...
EDO32210     360 epagEKTKQK-RKRAKNVLSDE--STDD-------ESPQASEQSVISETPV---------AEQQTKPRVSES-------- 412
P84798       316 ----ENMKKK-RRRIKLPESDS--SEDE----VIPDSP-GAYEAESPSPPPpspspepvlKTEPEPPPVKGSDG------ 377 domestic cattle
1_pfamImport 285 ----KMEKKK-RRRIKKPEPDS--SDED----VIPDSPQPVVTREPSSPSP---------KKEVEPDRHSHPSSs----- 339
Q7SAP2       300 ----KSKKER-EEELRRMMEDD--EDED--MEETADSP-APEEEEEEEPAVeeppakadvAKEEKKEIVTTSGD------ 363 Neurospora crassa
XP_001538907 325 ----ESRKER-EEKLRKMMEDE--DMED-VPEDVPELPPARAPERTDTSQ----------SEEVPKAESKEEARap---- 382
Q2UB13       313 ----ESRKER-EEKLKQMMEDDdeDEDE-EMPDATEPP-EESKPIDQPPP----------KKPELKEEITVQG------- 368 Aspergillus oryzae
XP_756008    313 ----ETRKER-EEKLRKMMEDE--DDDDeEMADVPEPPMEEEKTIDQPP-----------TKEEPREEITVSG------- 367 Aspergillus fum...
XP_011390219 433 taakRRVRKKRKIgTKKLRSKDERGYTVTKTIDEYESYSSDESDtPvvagskrtsgatkkeaPNKPAEARSTSASASAip 512
Q6CE56       362 ttttTAKRGKKKV-IKKVQELDEDGYVTYKKVETWESCDEDEDEsGlkeevk-----rdvkkEVKKEVKKESPEPAAG-- 433 Yarrowia lipoly...
EDO32210     413 ----AKRRKRQKV-LHSKTYMNDEGFMVTEKVYESESTDASDEE------------------PVEVKPAEPKKTSPQA-- 467
P84798       378 ----ENKRKRKRV-LKSKTFTDEEGCMVTEKVYESESCTDSEEE-L----------------KMKTSSVHRPPAM-AV-- 432 domestic cattle
1_pfamImport 340 ---eMKIRKRRRV-MKSHTFVDDDGCMVTEKGYVSESYSESEDDfK----------------PSKQASRDPIKAKPSS-- 397
Q7SAP2       364 ----GRRRGKRRV-MKKKQIMDDQGYLVTIQEPAWESFSEDEAP-P----------------ADKPKPKVANPAPPAA-- 419 Neurospora crassa
XP_001538907 383 ---kGRRRGRRQV-MKKTTIKDAEGYLVTKEEPVWESFSEDEAP-P----------------PVKRKLAVSVNSKSTS-- 439
Q2UB13       369 ----GRRRGRRQV-MKKQVRKDDEGYLVTVEEPSWESFSEDEPA-P----------------PPKKKPAVS--------- 417 Aspergillus oryzae
XP_756008    368 ----GRRRGRRKV-MKKKTVKDEEGYLVTVEEPTWESFSEDEPA-P----------------PPKKKPALS--------- 416 Aspergillus fum...
XP_011390219 513 apsaptkptSASNNsgprkpsggttpapAKKGQQSLNSFFtRK 555
Q6CE56       434 ---------AKKSK--------------KANKQSSLMSFF-KK 452 Yarrowia lipolytica
EDO32210     468 ---------NKKALd------------pKSAKQSSLMSFFgKK 489
P84798       433 ---------KKEPKeerkgpkkgtaamgKANRQVAITGFFqRK 466 domestic cattle
1_pfamImport 398 ---------SSKEDekktqkk-asansnKGTKQASIMGFFqKK 430
Q7SAP2       420 ---------AGKAKk------------pAPKGQGNIMSFFsKK 441 Neurospora crassa
XP_001538907 440 ---------SNKGS--------------QKMGQGNIMSFFgKR 459
Q2UB13       418 ---------ALKGKp-------------AGKGQGNIMSFFgKK 438 Aspergillus oryzae
XP_756008    417 ---------APKGKa------------gGKAGQGNIMSFFsKK 438 Aspergillus fumigatus Af293
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