6SEI,7CQ2,4XLG


Conserved Protein Domain Family
Slx4
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pfam09494: Slx4 (This model is not part of the current CDD release)
Slx4 endonuclease
The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.
Links
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Statistics
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PSSM-Id: 518936
Aligned: 72 rows
Threshold Bit Score: 50.2178
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6SEI_B         20 FRYITQAVVtaprakdpA---NPSWHEKMLMYDPIILEDLTAWLNSGqldrvgydgEVA---PGDVKKWCESKSVCCLW 92   Thermothielavi...
EFN82168     1115 KEAFTKLIN--------I---DKDLYNKILRYEPINIEQLHATLRLHg-------fKCK---LSNFMNFLDEQCITFYM 1172
EGI62403     1006 TEAFMKLIN--------I---DKALYNKILQYEPVNIDHLRCMLQTHg-------fKCK---LPNLMNFLDQQCITFYS 1063
EFX86110      802 KDHMKEFLK--------K---RPDIHKLVLTYEPISFEYLFAEIRKDr-------iRCK---AQDLLDWLDQECITCRM 859 
Q6CFP1        733 MSELTEFMM--------SapeARDMWLKMLTYQPISLSQLMEFNKEHg-------iKIS---KVLTIAWCDLHGVTWTS 793  Yarrowia lipol...
XP_001837284  413 QKALMKKIS--------E---DREIKLKILRYEPISLHVFHTLLIPGr-------tKLSlkhKTMLVAFLENEGITTYD 473 
XP_002932505 1619 AEAVKRFIE--------S---HPDLYKRILLYQPLELAALHAELKQAg-------iKVA---SGKLLDFLDTHCITFTT 1676
NP_001385580 1640 EEAVRRYIC--------S---QPALHRKVLMYQPLQLAELQAELKQNg-------iPVA---MGKLLDILDAQCVTFTT 1697
XP_007499143 1758 EEAVRRYIR--------S---HPALYQKVLLYQPFELADFQAELRQNg-------iKFA---MGKLLDFMDAHCITFTT 1815
XP_012910555 1670 EEAVRHYIR--------S---RPALYRKVLLYQPFELAELQAELKQHg-------iRVA---TQKLLDFLDAHCITFTT 1727
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