4XLG


Conserved Protein Domain Family
Slx4

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pfam09494: Slx4 
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Slx4 endonuclease
The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.
Statistics
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PSSM-Id: 401446
View PSSM: pfam09494
Aligned: 79 rows
Threshold Bit Score: 50.5772
Threshold Setting Gi: 116502006
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XLG_B              15 FEFLTHLVKQEPDLLTRIYCFQPITMNDLINKLRNKdsfvdLIDDGTIREWTDKLGICIRS 75   [Candida] glabrata CBS 138
EFA07432           946 HIAWHNLVMSNPKIREDILLYEPLQLENLHSMLKEQg---fKYNIQDLLTFLDKKCITIRT 1003 red flour beetle
Q16YM9             652 HIAFHNMIHENPALRRQMLRYEPIDLDAIYSHLKEIg---lRYESNDLISFLDKRCITFRT 709  yellow fever mosquito
EDS35182           463 HIAFYNMVKANSTLRQRILRYEPLDLDAIVGHLKEIg---lRYDSNEMIAFLDKRCIAFRS 520  southern house mosquito
XP_004923479       582 HIAFHNYVSCRNGLREAILKYDPVNIDVIHKELAGYg---hRYDPKDLLKFLDKRCITVKT 639  domestic silkworm
FlyBase:CG8601-PE 1068 HIAWHNLICANPQLHESVLTYEPIDLQAVYLHLKHMg---hRYDPKDLKTFFDRRCIIFRY 1125 fruit fly
XP_002062409      1068 HIAWHNLICANPQLHESLLMYEPIDLQEIYMHFKQMg---hRYDPKELKSFFDRRCIIFRY 1125 Drosophila willistoni
XP_002046400      1071 HIAWHNLLCANPDLHERVLHFEPIDLQEIYLYLKQLg---qRYEPKELKSFFDRRCIIFRY 1128 Drosophila virilis
XP_012910555      1680 EEAVRHYIRSRPALYRKVLLYQPFELAELQAELKQHg---iRVATQKLLDFLDAHCITFTT 1737 domestic ferret
XP_001505289      1118 EEAVRRYIRSNPALYRKILLYQPLELGELQAELKQNg---iKLAMGKLLDFLDTQCITFTT 1175 platypus
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