Conserved Protein Domain Family
DUF2389

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pfam09493: DUF2389 
Tryptophan-rich protein (DUF2389)
Members of this family are small hypothetical proteins of 60 to 100 residues from Cyanobacteria and some Proteobacteria. Prochlorococcus marinus strains have two members, other species one only. Interestingly, of the eight most conserved residues, four are aromatic and three are invariant tryptophans. It appears all species that encode this protein can synthesise tryptophan de novo.
Statistics
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PSSM-Id: 490415
Aligned: 48 rows
Threshold Bit Score: 46.5216
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002507872 147 TNWTAHRRTK-GWRHFECIGkspadKANGKPRASVHLAATCDRDvTVWVDVKELKDRHLWSAGW 209
WP_011770222  22 SKWTKITVLN-KEKHFLVSEve-fnE--DKKIIRCVMQAVINHA-EYEINWRSLKEGKEWLIGW 80  Psychromonas ingrahamii
Q07Y30        14 SKWTKVNVVQ-KLKHFTVAKve-ydE--QQNVVECFIRAEMNAE-EFSIDWRDLKDPQLWKIGW 72  Shewanella frigidimarina NCIMB 400
VBC:LBF_4207  18 SKWTSVNILD-REKHFIVTKvh-wqEGSTDTLDQVTIEAILTKK-SKMIPWENLKDNAQWLPGW 78 
WP_014802033  18 SKWTAANPTN-GEKHFLVTRi------aDHKRRELKLECVVTRR-SFILPLSELTNAANYTSGW 73  Turneriella parva
WP_013819905  13 SKWTAVAPRN-KEKHFIVTKll-lpENPPTPLEFIELEAVYSKR-VHVLPWRALNDTAAWRPGW 73  Methylomonas methanica
2_pfamImport   1 SKWTALAPQN-KEKHFIVVRvl-epEHPDAPITEVELEAVYSRR-SRIIPWKTLTDATQWRQGW 61 
Q888A5        12 SKWTAATPQN-REKHFLVTElf-kdE--EGVVLEVELQAVLTQR-SERMPWQVLQQADAWRMGW 70  Pseudomonas syringae pv. tomato
WP_013790047  16 SKWTAATPQN-REKHFLVTElf-cdE--EGTVLEVELQAVLSKR-AQRLDWRDLQNAERWLMGW 74  Pseudomonas
WP_011705034  12 SKWTKESRHElTERFYLVVAcq-rdA--QGQLQQVVMQDINTLL-EQEMDWHELEDPAHWHMGW 71  Aeromonas
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