4EYY


Conserved Protein Domain Family
Dot_icm_IcmQ
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pfam09475: Dot_icm_IcmQ (This model is not part of the current CDD release)
Dot/Icm secretion system protein (dot_icm_IcmQ)
Proteins in this entry are the IcmQ component of Dot/Icm secretion systems, as found in the obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii. While this system resembles type IV secretion systems and has been called a form of type IV, the literature now seems to favour calling this the Dot/Icm system. This protein was shown to be essential for translocation.
Links
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Statistics
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PSSM-Id: 518925
Aligned: 4 rows
Threshold Bit Score: 256.092
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4EYY_Q        13 ILKALNDAIEKGPWDKSNFLRVIGKKLIAIRDRFLKRigaasqaQLQAESHLANQI----ALQSGQQEIYVSLYSSDGSN 88  Legionella pneu...
Q83B79        58 IIQATGQVLSAANWEESLFLRNTLKPIKKLYEEALAL-------KEKLDGEQAGQAfttpALTENKVKLYVSLYQSNGHD 130 Coxiella burnetii
1_pfamImport   2 ILKALDDAIEQGPWEESNFLRVIGKNLREIREHFASQvqtsgqgKEKIASHLANRI----ALRSGQREIFVALYSSSGSS 77 
Q5ZYC8        21 ILKALNDAIEKGPWDKSNFLRVIGKKLIAIRDRFLKRigaasqaKLKAESHLANRI----ALRSGQQEIYVSLYSSDGSN 96  Legionella pneu...

4EYY_Q        89 LQSWEKIVGSLPRQMISRPIYADEEDIKAILKTKENKQNEAYVAIYISQSDILHlSADKAPVDKLGKPLLTLKDKSISLE 168 Legionella pneu...
Q83B79       131 LKQWALQLASLESYMVGRPIYQNEADAMQAIRQKLSQLSEACVVVAVDQSKIIS-QENRSRKDRLGNLLTTVMPNAIKSE 209 Coxiella burnetii
1_pfamImport  78 LSSWERIITNLPGQMISRPIYANEKDVKEIIGTKENKVNEGYVSIYVSQTDILPtSPEKTPTDKLGKPLLTLKDRALKLE 157
Q5ZYC8        97 LQSWEKIVGSLPRQMISRPIYADEEDIKAILKTKENKQNEAYVAIYISQSDILHlSADKAPVDKLGKPLLTLKDKSISLE 176 Legionella pneu...

4EYY_Q       169 NISRFVHVSGVYRYSNgrliKN 190 Legionella pneumophila str. Corby
Q83B79       210 NIIEFIHQGKRYHYVN----QA 227 Coxiella burnetii
1_pfamImport 158 NLNRFIHMTGTYKYVGgrlvK- 178
Q5ZYC8       177 NISRFVHVSGVYRYSNgrliKN 198 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
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