8Q3V


Conserved Protein Domain Family
MtrF

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pfam09472: MtrF (This model is not part of the current CDD release)
Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)
Many archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This domain is mostly found in MtrF, where it covers the entire length of the protein. This polypeptide is one of eight subunits of the N5-methyltetrahydromethanopterin: coenzyme M methyltransferase complex found in methanogenic archaea. This is a membrane-associated enzyme complex that uses methyl-transfer reactions to drive a sodium-ion pump. MtrF itself is involved in the transfer of the methyl group from N5-methyltetrahydromethanopterin to coenzyme M. Subsequently, methane is produced by two-electron reduction of the methyl moiety in methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase. In some organisms this domain is found at the C terminal region of what appears to be a fusion of the MtrA and MtrF proteins. The function of these proteins is unknown, though it is likely that they are involved in C1 metabolism.
Statistics
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PSSM-Id: 518923
Aligned: 18 rows
Threshold Bit Score: 62.2832
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8Q3V_F         4 LSNKPNIRGIKNVVEDIKYRNQLIGRDGRLFAGLIATRISGIAIGFLLAVLLVG-VP 59  Methanothermobacter marburgensis
WP_015286573   7 stgPVRMVAIDNMVENIRYKSQILARTNKIDSAVTASGLVGFVAGLLTALILIV-LP 62  Methanoregula formicica
2_pfamImport   4 TVLAPFMGPFDQITDSVLYRAQLVVRDQKLSSGVNAAMPIGAVVGFLFAILMVL-LP 59 
A0B8Y1        14 AVIEPAMPLFDQIVDDIKYKAQLLARETKLSSGVIAAAPQGFAIGFFLAVAMVL-GP 69  Methanothrix thermoacetophila PT
WP_013718860  13 AVIEPNMPMIDAIVEDVRYKGQLLARETKLSSGVMSTVSVGFAIGFVLAIVMML-GP 68  Methanothrix
Q0W333       187 AAAKPD-KEIPPLVDDVCYRAQLCARNQKLTSAVGATKVLGFVLGAVFVIAFVL-IP 241 uncultured methanogenic archaeon
WP_016359086   4 ISNKPNVRGLKNTADDIEYSSKLIGREGRAYAALSFTRTKGIGIGVTIAFVLLIlLP 60  Methanobrevibacter
WP_012956716   4 FSNKPNTRGIRNASNNVEYRAKLLGREGRLFAGVISTRFSGMAIGIGLALALAVvIP 60  Methanobrevibacter ruminantium
O27226         4 LSNKPNIRGIKRVVEDIKYRNQLIGRDGRLFAGLIATRISGIAIGFLLAVLLVG-VP 59  Methanothermobacter thermautotrophicus...
Q58262         5 VSNKPNVSSIQSYVEDLEYKVGLITRNRGLESGTESAGTKGLIIGVVSAIVLMG-IP 60  Methanocaldococcus jannaschii DSM 2661
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