6VME


Conserved Protein Domain Family
Vps23_core
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pfam09454: Vps23_core (This model is not part of the current CDD release)
Vps23 core domain
ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (pfam03997) and Vps37. Vps23 gives ESCRT-I complex its stability.
Links
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Statistics
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PSSM-Id: 518913
Aligned: 97 rows
Threshold Bit Score: 54.396
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6VME_B         9 EVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALR--RGVID---LDVFLKHVRLLSRKQFQLRA 68  human
A0BPW4       218 lqhisTTPYQDQLIELDAKIKGIRDTLRLIQHNFQ--NNHLN---FLELNQFTRNLAKEEFDAFL 277 Paramecium tetraurelia
A0CR15       375 eelmQTDPLSNQIIDLTSEIQAQKEGLYYVQKKFR--HQNLD---YDQLIKITRQMSQQMFDQYL 434 Paramecium tetraurelia
Q24HU3       343 NFIKEQNPLQNQILELTSEQEAIKETIIYIEEAFK--QKKID---FETLIKSIQYYSELEFNTKL 402 Tetrahymena thermophila SB210
XP_036666783 427 ELIIPDSPLVKQLYEVVSEIKAIKDTLNLISGNFHgcKEVVNdknLDVCVKTVRNLGRELFWLel 491
XP_002549765 435 DLIIPDSPLTKQLYEITSEIKAIKDTINLITGSFHnqQETINddrFDTCVKMVRNMGRDLFWLel 499
Q59WF8       408 EIVIADSPMIDTLYKVSAEINSITDTINLISGNFHneQEIVNeksFDSCLKTTRKMGRELFWLhf 472 Candida albicans
XP_006689532 412 EVVISDSVLTNQLYEISSEIKANNDCMSLIGGSFDneNELIDdasFDTCVKTVRGIGRDIFWLKL 476
EMG45623     430 DLVIPDSPIVKQLYEITSEIKAIKDTISLISGSFHdqPELVNddrFDACVKAVRNLGRDLFWLel 494
XP_001387816 456 NLIIPDSPLVRQLYETVSEIKAVRDTINLVSGSFHseKELINdarMDLCVKTVRNLGRELFWLel 520
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