Conserved Protein Domain Family
Mvb12

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pfam09452: Mvb12 
ESCRT-I subunit Mvb12
The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified, multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23).
Statistics
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PSSM-Id: 370502
View PSSM: pfam09452
Aligned: 15 rows
Threshold Bit Score: 101.231
Threshold Setting Gi: 74605715
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH59574      10 LRQLPLINSKGVG--FPQeSVVSKLnegqtqtqgQIQTLNLNRSVNT-KE-MFEPWYKECDELKNRLEKD-IREGETFHD 84  Tetrapisispora ...
XP_003955835  10 LRKIPLYNKYGDD--YPD-KMLPKL---------DVPEIKIQPLPPI-NK-TIEAWITELDKAVDYWSKYsDNNIKEFND 75  Kazachstania af...
XP_001647043   9 IRGIPLYNAYGVM--FPNvNKLRKF---------TSDVIDVPVVRGT-DE-MFNPWYKECEHILNDCNGH-DSSFKTFDD 74  Vanderwaltozyma...
CCE61565       7 LKGIPLYNAFGES--FPSqKNLNRL---------TVPNINVPASQQQpSE-MFKPWYKLCNDLIEGCNNH-DKSSEDFEK 73  Tetrapisispora ...
XP_002498484   8 LRNRPLVNSRGSK--FPH-EVPPRL---------HIPQIKLQPLQPA-SQ-MFGPWYNECDQLVQLAELH-DKRSQQFES 72  Zygosaccharomyc...
XP_002551849   9 LHQIPLRNAHADL--LPQ--AQRKL---------DLPPLALPETTPA-KQ-HLEAWIEECSQISQAIKQR-KDRGKRFDT 72  Lachancea therm...
Q6CN00         5 LRKVVLYHGVESSekWPK--GRKKL---------TLPSLQLLPDTDT-AE--LQQVIQFNSDIEELIRQR-QESKETFDK 69  Kluyveromyces l...
Q75CP7         5 LRKIPLYNAFEGD--MPR--RRAKL---------QLAALQIAPAAAT-GE-HLAAWDEECRRVLESVQQA-RAQGGEWEA 68  Eremothecium go...
CCK71131       9 LRRVPLYNKRGVAggGPP----APL---------EVPTLQPPQRHPGgSEsLVSPWIHECESLEAQLQGY-IGQGALFDQ 74  Kazachstania na...
XP_003673671  48 LRKVPLYNKFGPD--FPR-EKLSRV---------RVPEFRLEPLQSS-EE-MFQSWHKECDNLTRSCQFH-DKGSQMFDK 112 Naumovozyma cas...
CCH59574      85 WYKEKYLNKIPPGLLDGqmNVLSPSKK 111 Tetrapisispora blattae CBS 6284
XP_003955835  76 WYNKKYLSNKPPGLVNS--SVLSPVHK 100 Kazachstania africana CBS 2517
XP_001647043  75 WYKEKYLSSKPHGITDN--ITLTPVKR 99  Vanderwaltozyma polyspora DSM 70294
CCE61565      74 WYEDRYLKNKPHGMRES--IVLSPSKK 98  Tetrapisispora phaffii CBS 4417
XP_002498484  73 WYVSQCLSKKPPGMAM---TMLSPSRR 96  Zygosaccharomyces rouxii
XP_002551849  73 WYAENCLSKQPPGITDC--AVLSPSRR 97  Lachancea thermotolerans CBS 6340
Q6CN00        70 WYQETYLASKPKGLLEH----LAPKRR 92  Kluyveromyces lactis
Q75CP7        69 WYEQTYLRKQPPGLLES--GTLRPRRK 93  Eremothecium gossypii
CCK71131      75 WYASTYLAHKPAGLLSH--KVLSPT-R 98  Kazachstania naganishii CBS 8797
XP_003673671 113 WYFDTYLKNKPPGMIEK--NVLSPSKR 137 Naumovozyma castellii CBS 4309
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