6W17


Conserved Protein Domain Family
SPIN90_LRD
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pfam09431: SPIN90_LRD (This model is not part of the current CDD release)
SPIN90/Ldb17, leucine-rich domain
This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.
Links
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Statistics
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PSSM-Id: 518899
Aligned: 80 rows
Threshold Bit Score: 94.8631
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6W17_H       190 DSFGMCVLTL-LSINEQFMLvrlASkgsfeIANGIMDLLSsSKVDNGIYSEGLVFTLNREKDPRSRM--------LILKQ 260 Schizosaccharom...
XP_974006    438 EQIPDLFLNCvISFNLQFED---CD------ENPVLSALE-ERDVAKTFTEKILLLLNREHDPVRIFehepapphALLKL 507
XP_025158086 484 DQIPDLFVNLiLSYNLQFTT---S-------ENIVLNALR-ERTVAKTFTEKILFLFNREEDPVRIFdhepqpphSVLKL 552
XP_008216306 469 DQIPDLFINLiLSYNLQFQT---S-------ENVVLDALK-ERTVAKTFTEKILLLLNREVDPVRIFdhepappdSILKL 537
XP_002428193 502 DQVPDLFIALiLSYNLQFKN---SQ------DNVVVKSLS-QRPVAKVFTEKILLLLNREDDPVRIFehepaprnSILKI 571
EDX17383     243 EVLVDMVIALiLAFNQQFSE---HT------YNVIIEGMQ-NLPSAKVFTEKLLLLLNREDDPTRLLkhpnehmnTVLRM 312
Q7QEZ1       642 EVLPDIMINLiLSFNLQFDN---FA------ENVVLEAME-QFKTAKTFTEKILLLINREEDPVHTLkhtpmninPVLKM 711 Anopheles gambi...
7_pfamImport   2 TEISDLLLTLlLSYNLQFKP---KA-----VANITVQAVM-EAPSVKTFTEKVLLLINREEDPITKLkthetpyhSVLKL 72 
XP_048583045 428 DKIIESFVHLlLAFNQHFTD---PK------TNIVMNVLS-ELYSAKTVSEQLMLLVNREEDPVVMFdypkscanSVFKI 497
5_pfamImport   2 SDFDDIFVRLiLAMNLHYIT---PH------DNPTMGVMG--GQTCTTFSEKVMLLINRGDDPVA-ItehttpphSVLKF 69 

6W17_H       261 LFLLFTTPATYE-IFYTNDLNVLIDIFIREINNIpdELSDLRYAYLQVLIPLLENTQVRHpPHYKTKCI 328 Schizosaccharomyces pombe ...
XP_974006    508 FVDLLSRKTTAA-LFYTNDIKVLIDIVVRNVADLs-PGDKRRQQYIELCRLVMRNTNYDE-HRHRLDDI 573
XP_025158086 553 FIDLFSNDVIAS-LFYTNDVKVLIDIILRQLFDMf-PGDKRR-QYLELCRRVLRTSSYNE-HRHRSEDL 617
XP_008216306 538 FVDLFTSDETAS-LFYTNDIKVLIDIILRQLFDIa-PGEKRR-QYLELCRRVLKTAVYEE-HKHRCEDV 602
XP_002428193 572 FIDIFSHRNTAN-LFYTNDVKVLIDIIVRQLADLs-PDDQRRNQYLQLCKLVMRNSEYSE-HHHRKDDL 637
EDX17383     313 FIDIFSHPDTAG-MFYTNDIKVLIDIVVRQLSDLd-AGSTTRPCYLELCRRILRNTNYQE-HQHRKHDL 378
Q7QEZ1       712 LVDLFSRPETAS-IFYTNDNKVLIDILVRQLSDLs-AGEPIRKWYLELCRKILRNTNYPE-HQHRKQDL 777 Anopheles gambiae str. PEST
7_pfamImport  73 LNDLFSYSATAK-LFYTNDVKVLIDIIVRQITDLt-PHNKKRTEYLELCKLIMYTCDDTA-FEHRLDDL 138
XP_048583045 498 FTDLFSSPSTSG-LFFTADMKVLIEIVLRQLTDLs-PGEKVRTEYLALLELMLTNSDYGS-HQHMCSDL 563
5_pfamImport  70 LQDIFSRVDTGRnFFYTNDLLVLIDIIIRNISDLp-PGATARTEFLDLLLNLLHKSTYSE-LKHRNQEI 136
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