Conserved Protein Domain Family
DUF2014

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pfam09427: DUF2014 (This model is not part of the current CDD release)
Domain of unknown function (DUF2014)
This domain is found at the C terminal of a family of ER membrane bound transcription factors called sterol regulatory element binding proteins (SREBP).
Statistics
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PSSM-Id: 490368
Aligned: 40 rows
Threshold Bit Score: 259.066
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009216333  633 KTMKLSLRNTIGV--QQYQALTGLTE-----EQETARVKAWAIALDAQLAGGDVEINKSRLTLTLLASGTLPDTPLRLML 705 
XP_002480172  484 RWVEYSVCCLVGR--SVYSWITGITE-----EDEKGRIKTWDIAIDAQLAGGDTEVSKSRLVLTIFASGTLPRSPARIML 556 
GAD97007      508 RCFEYCLRCLLGW--KLYSHITGITE-----EDEKGRVKTWDIAIDAQLAGGDPEISKSRLVLTIFAAGTLPRSPLRMML 580 
1_pfamImport    1 RCFEYVLRCLMGW--KLYSWATGITE-----EDERGRVKTWDIAIDAQLTGGDVEISKSRLVLTIFAAGTLPRSPMRMML 73  
XP_001273183  507 RCFEYVLRCLLGW--KLYSWVTGVTE-----EDERGRVKTWDIAIDAQLAGGDTEISKSRLVLTIFAAGTLPRSPMRMML 579 
XP_001537796  460 RCLEYVLSCLLGS--KLYSWLTGITE-----DDEKARAKAWDIAIDAQLTGGDPEVSKSRMVLTIFASGTLPRTPARVML 532 
XP_003238624  557 RCLEYCVRCLLGW--KLYSFVTGISA-----DDEKGRVKAWDIALDAQLTGGDAEVSKSRLVLTIFAAGTLPRSPARMML 629 
EFW18200      565 RCFEYLLRCLLGW--KLYSILTGISE-----DDEKGRVKAWDIALDAQLTGGDAEVSKSRLVLTIFAAGTLPRSLSRMML 637 
Q6C906        423 AMGKALLRFLIG---DGYLLLQSSSY-----HLPISR------AVEAQLCGGQENMSRADLFVTYLQTLTLPPTPALCAT 488  Yarrowia lipo...
XP_013023578  522 GLLIFIVKSSINYinHRISGLYASSEtwvysEQQLADIRNLEKLLDAQLMGGDEKVNRLRLFMVFASSFFLPTTSHTSAL 601 
XP_009216333  706 KALHIRVLLWQL-GQGGIH----NVVAAKLARAKWNQAKQLHRLSKASSSprlsaqeqiPSDDSLPDHLAVLLDQ-ECDD 779 
XP_002480172  557 KAFHCRILLWRVgQPGSFVstvaNHVGRVLATYQWNLARELNRSLPKDHP------------DALPSHLSALVET-ECND 623 
GAD97007      581 KALHCRILLWRVgDPGTYTykvsNDVARHLANYQWQMARKMNKRLPKDHP------------DALPSHLAALLEI-DCED 647 
1_pfamImport   74 KALHVRILLWRVgQSGSWTcrvsNDVARALAKYQWAVARELNDALPAGHP------------DQLPGHLSALVKL-DCED 140 
XP_001273183  580 KALHCRILMWRVgEPGSWTfkvsNDVARSLARYQWDLAREMNNTLPQGHE------------DALPRHLAALLKI-DSDD 646 
XP_001537796  533 KALHCRILLWRVgSPGSWAfrlsNHIGSLLARYQWDIARNLLKNLPKDHE------------DALPEHLVTLLEA-DLDD 599 
XP_003238624  630 KAFHCRVLLWRIsSPDSLAfrvaNYIAKVLANYQWELAQNMHRRGPKRGE------------DPLPSHLAFLLSM-DCDE 696 
EFW18200      638 KSLHCRILLWRVgSSGSIAckisDHIAGILAKYQWQLAQQMQKLTPEDHE------------DALPSHLAYLLQH-DCED 704 
Q6C906        489 QAIHVHVLA--------NGlpwlKKASVIMADRHWKQARKLAS----------------QKKHAVPSYLSLLLAQ---ND 541  Yarrowia lipo...
XP_013023578  602 QAMYSELIF--------SNspmpSAFVSKCASFFWNRAKRLQSSASMQSD-----------LQELPECVVKLIETcDAED 662 
XP_009216333  780 VLNDDVVQRAHNLAWNRPTTHDV--AADIDGMNAVVEDPAIKSPMDAVAAWWSSLVLHQVLTTSLdiattttekGDSEQE 857 
XP_002480172  624 VLIDPIVQRAVNLTWSRPTQEGL--DEDEALLDVVAEDPAVQTFADSIAAWWSSHVLQTALLNSFn-------iDSDGGY 694 
GAD97007      648 VMIDPIVQRAANLTWNRPTQEAA--DDDQALLDVVVEDPAIQSSLDSLAAWWSSHILQRALLRSFeas----saGPSAKK 721 
1_pfamImport  141 VMIDSIIQRAVNLTWNRPTQEGA--TDDEVLLDVVEEDPAIQCSVDALAAWWSSHLLQNALLNYLeas----egSSTSKK 214 
XP_001273183  647 VMIDSVIQRAANLTWNRPTQEGT--DDDEALLDVVEEDPAIQSSLDALAAWWSSHMLQRALLRYFevs----sgGPDVKK 720 
XP_001537796  600 VMTDAITQRASNMAWNRSTQEAT--YGEDAMLDIVVEDTAVRSPLDALAAWWSSRALQNALIHCLdf-----daFPPEQK 672 
XP_003238624  697 VFTDTIVQRASNMVWNRPTQEAT--DGEDALLDVVVEDSAVRSPLDVLAAWWSSRALQEALLKSLdl-----vsVESPIE 769 
EFW18200      705 VFTDAIVQRASNMIWNRPTQEAT--DGEDSLLDVVVEDSAIRSPLDAIAAWWSSRALQEALIHSLdv-----tsADCGTR 777 
Q6C906        542 VFDSDIIQRFYNFAHGLDASHGCslGMLDEGFITATSDSALKTPLDVLAAWYSTRTLREVILFQL--------------E 607  Yarrowia lipo...
XP_013023578  663 IFSSWMVKRLWTLA--RCTRDSA---KLPNSIISKLSDVVVMSPLETTASWYAVDLLEALLMESL--------------- 722 
XP_009216333  858 PSTSSINedDLTLAAKVAPVGSNAQVRALVARAFLVKANRGANMVAALEAMA 909 
XP_002480172  695 GKKKLEQ--QINLALQVAPRLSAAHTRAAAMRAVLYEQNRLYDIKTVLNALP 744 
GAD97007      722 CRGILYR--KVTTALNVAPRPSAAYTRALVMKAVFFEEDRIQNIGAVLAALP 771 
1_pfamImport  215 SRDIFKE--KIRMALDVAPRLSAAYTRALVMKAVFFDKDRVENVGAVLAALP 264 
XP_001273183  721 NRHIFKT--KIKTALDVAPQPSAAHARALVVKAVFFEQDRVVNIGKVLAVLP 770 
XP_001537796  673 LREVFEL--NLNLASNVAPLASAAYTRAAVIKAVFFGEDRVTNINTVLAALP 722 
XP_003238624  770 KRKSFER--SLDIALHSAPIPSTAYTRATVVKALFFEEDRINNVNTVLATLP 819 
EFW18200      778 RREAFER--NLEMALKSAPPTSAAYTRAAAIKALFFDEDRVANINSVLAALP 827 
Q6C906        608 ANEVDYN--KLDTAQAVSPVNSIAKRRAAIAHSVVLGRKDSNLVKDALVMVK 657  Yarrowia lipolytica
XP_013023578  723 DHRIEKS--EIDKVLSLSPKNSPVYRHALVAKLVLFEDNTSESLTEVLAAYN 772 
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