Conserved Protein Domain Family
AMER

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pfam09422: AMER 
APC membrane recruitment protein
This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning. WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia.
Statistics
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PSSM-Id: 490363
Aligned: 13 rows
Threshold Bit Score: 348.063
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
F1QGH6          1 MEVQTEC-SEP----------------------------PPCDp--QPPGKLNKAAFKLFGKRKSGSSMPSI--FS-VRN 46   zebrafish
E1C2Q8          1 MDSHCDC-AEP----------------------------PAAE---QPSGKINKTAFKLFKRRKSGGTMPSI--FG-VRS 45   chicken
2_pfamImport    1 MEVQTEC-AEPpv-------------------------aPQCDp--QPTGKINKAAFKLFGKRRTGSGMASF--FS-FRN 49  
5_pfamImport    1 MEVQSDC-VEPpv-------------------------aPQCDt--QPAGKINKAAFKLFGKRRTGSGMASF--FS-FRN 49  
XP_007252366    2 MEAQTDC-IEP----------------------------PSCEp--QPSGKINKAAFKLFGKRRSGSGMPSI--FS-VRN 47  
Q8N944         14 LQVSHEKpPDPaa------------------------vaAAREg--TGPWSVLPGGQQRPHSEKGPQASPSAqeYDrCPN 67   human
Q6NS69         14 VQISHEKlIDS----------------------------PAKEd--PDKWPLSLGEQQRAYGEKSSQTSPCSqgYGrCPN 63   house mouse
NP_001102790    1 MEIQQDEtVQIkrtstssdaqdqgaekgaknktaettegSTSEpplSGPGRLKKTALKLFGGKKGICTLPSF--FGgGRS 78  
Q5JTC6          1 METQKDEaAQAkgaaasgstreqtaekgaknkaaeategPTSEpssSGPGRLKKTAMKLFGGKKGICTLPSF--FGgGRS 78   human
3_pfamImport    1 MDLHCDWaADT----------------------------PA-E---QPSGKINKAAFKLFKKRKSGGTMPSI--FG-VKN 45  
Q8CCJ4         38 MDSHCECaAET----------------------------PAAE---PPSGKINKAAFKLFKKRKSGGTMPSI--FG-VKN 83   house mouse
1_pfamImport    1 MDLPCDCaAGT----------------------------PASE---QPSGKINKAAFKLFKKRKSGGTMPSI--FG-VKN 46  
XP_005990615    1 MDLQYDS-TDT----------------------------PVSE---QHPGKINKTAFKLFGKRKSGSNMPSI--FG-VKS 45   coelacanth
F1QGH6         47 KGe-STGKAAGKt--------------LELVRSKTHDGLITdt-------pSELDSHRKEESASSDQLHAGtpdg----v 100  zebrafish
E1C2Q8         46 KG--GEGKGASK---------------TGMVRSRTHDGLAD----------AVLESGKKEDAGGGEAQGKD--------- 89   chicken
2_pfamImport   50 KGa-TNGGSNGNpdngnsvngngsaasAELVRSKTHDGLTSs--------nSDADGQRGEGLAIle-------------- 106 
5_pfamImport   50 KAa-AN---------------------AELVRSKTHDGLTGs--------nNEAVGQRGEGLTSle-------------- 85  
XP_007252366   48 KGe-GGSKTSGK----------------ELARSKTHDGLVTdv-------pSDLEGSKKEDSCSSDLLHSApveg----v 99  
Q8N944         68 KGaqLDPKGGPAalcg--------atfKPVRKCKTHDSMSGagrataatgqLVGSASFPGSPGSRRMIDYRhfv------ 133  human
Q6NS69         64 KEvlSDPEGGPVplcg--------ttfKLVRKSKTHDSVPGavkaaaptgqMVGSTSFSETPGGQRMIDYRhfv------ 129  house mouse
NP_001102790   79 K---GSGKGSSK---------------KGLNKSKTHDGLSEsshg---pedVVVEETELSTPls---------------- 121 
Q5JTC6         79 K---GSGKGSSK---------------KGLSKSKTHDGLSEaahg---pedVVSEGTGFSLPlp---------------- 121  human
3_pfamImport   46 K---GDGKSSGP---------------TGMVRSRTHDGLAEv---------VVLESS----------------------- 75  
Q8CCJ4         84 K---GDGKSSGP---------------TGMVRSRTHDGLAEv---------LVLEGSKKEEPPGGSDHSGArp------- 129  house mouse
1_pfamImport   47 K---GDGKGAGP---------------PGMVRSRTHDGLAEv---------VVLEGGRKEEPRGGGDGGGGggdrgggrp 99  
XP_005990615   46 K---GDGKSSCK---------------MGMVRSKTHDGLAD----------VVVEGSKKGESSSSDQLNTD--------- 88   coelacanth
F1QGH6        101 stAPLRS-----------SITKSFSFFSLLRRSSSRA-GDGT----------TTVGRRGRGLKGLFSSMRWRRKPQIQED 158  zebrafish
E1C2Q8         90 --APSRAagglg-gsassSVAKSHSFFSLLRKNGRPEnGKAAena-----eqRAGGRQKKGLKGIFSSMRWHRKDKIGKE 161  chicken
2_pfamImport  107 -aGPVRS------------LSKSLSFFSLLRRGSFRSgENGG----------AGLVRRGRGLKGFFSSMRWRRKEKTNEV 163 
5_pfamImport   86 -aGPVRS------------LSKSLSFFSFLRRGSFRTsENGG----------TGIVRRGRGLKGFFSSMRWRRKEKTSEA 142 
XP_007252366  100 slAPVRS-----------AITKSFSFFSLLRRNSTRV-GDGA----------ATLGHRGRGLKGLFSSMRWRRKPPPRED 157 
Q8N944        134 pqMPFVP-----------AVAKSIpr------------------------krISLKRPKKCFRNLFH-IRRNKTEDLAS- 176  human
Q6NS69        130 pqMPFVP-----------AVAKSIpr------------------------krISLKRSKKCFRNLFH-MRRSKTENLAS- 172  house mouse
NP_001102790  122 -kSPSQ-------------FPSSQSAHGALEIGSRHKtSVTEavekagvekvPSVHKPKKGLKGFLNSIRRHRKSKVSGA 187 
Q5JTC6        122 -eLPCQ-------------FPSSQSAHGALETGSRCKtSVAGatekavaekfPSMPKPKKGLKGFFSSIRRHRKSKVTGA 187  human
3_pfamImport   76 ----XRApgtavgslvnsSVAKSHSFFSLLKKNGRSEnGKGDpad-----asKAGGKQKRGLKGIFSSMRWHKKDKRGRE 146 
Q8CCJ4        130 ipGPPKPsgpglgslassSVAKSHSFFSLLKKNGRSEtGKGDhae-----asKAGGKQKRGLKGIFSSMRWHRRDKRGKE 204  house mouse
1_pfamImport  100 npGPNRSvgp-------------------------grgGRGElpa----yasPP--TKARASECFFSSVRWHRKDKRGKE 148 
XP_005990615   89 --TNTKTvtsas-vslssSVAKSHSFFSILKRNGKSEnGKGEns------dqKAGNRQKKGLKGLFSSMRWHKKDKSHKE 159  coelacanth
F1QGH6        159 TLEVa---KEVKEGDLILSSSsgs-vkTEKD-MTLTLEPLPQVFEESPLPgds----dkwKVASMQGIQGTNEVECGNCG 229  zebrafish
E1C2Q8        162 ERGE----ASEIPSGLIMPGS------LTAS-LECIKEETPKPLSETPNGagdtgvesqqEKRGGDACVSAEEPQAGGGE 230  chicken
2_pfamImport  164 DAEEae-rKAEKDGEVGDPER-------AKD-ITLTLEPPPHHHQV--------------DCGDA---AASPDPETHSTS 217 
5_pfamImport  143 EGEEve-gKKARDTDATESET-------LKD-ITLTLEPPPHHHQE--------------DCASAETGSNLQASDTPTTS 199 
XP_007252366  158 SSEIqevaKEVKEGDVILPSTsnkvetLEDS-VTLTLEPTVRVFEECPTEdns----gtwDKNSLEEVKSSNE-ESRKSS 231 
Q8N944        177 ---------------------------LAAE---------------------------------GKSLPSPGDPSDPGGR 196  human
Q6NS69        173 ---------------------------LSAK---------------------------------GKNLSPSGVPAQQG-- 190  house mouse
NP_001102790  188 DQSGl--gAKELEGTRTMSQEh----vSSIS-LPSSEEIFRDAIKENTKP----------QDAPGPKMSPAREHFSLTTE 250 
Q5JTC6        188 EQSEp--gAKGPERVRARPHEh----vSSAPqVPCFEETFQAPRKENANP----------QDAPGPKVSPTPEPSPPATE 251  human
3_pfamImport  147 EEPRg---RAAGPGSLILPGS------LTAS-LECVKEETPRAAREPERPsedaprdpagELGGGEEVPAAAAERAPARS 216 
Q8CCJ4        205 EEEKa--vRAAGPGNLVLPGS------LTAS-LECVKEEPPRAARRPDSPgqdasrhaagEPAGGEQAP-ASAESAPERI 274  house mouse
1_pfamImport  149 SAGR----PSGGPAGLALPGS------LTAS-LECVTEEAPRPRVRAGEPeqd----pagEPGVGEPAP-ASAERPEVPR 212 
XP_005990615  160 EKED----SSENQSSIILPGS------LTAS-LECVKEKVQKPLSELENDreqaekespcESNSNEVNASVNKPEA---- 224  coelacanth
F1QGH6        230 PSVSQQHt-------------VTEESPAPSPLRVQTGglqnhkhSSSTHLSSIPTCALTPPMEH---------------- 280  zebrafish
E1C2Q8        231 SRDSKTPpge--------dpaAAARRLEELCGERPDPgagevgtAKDAAITGDIPITTIPPVEPhcdsgqe---taaapd 299  chicken
2_pfamImport  218 VTITPPLcvvampgqscepdsPIPYTPTDSPLRPPTQ-------KAKASISSLTPSLATPPLDRc--------------- 275 
5_pfamImport  200 VTMTPTHcvampgp-sgepdsPFPYTPTDSPLRPSIQ-------KAKASISSLTPSLTTPPLDRc--------------- 256 
XP_007252366  232 CSLVQE---------------ITEESPAPSPLRVPTEgplrantSGSACLTSIPASAMTPPLEH---------------- 280 
Q8N944        197 RS------------------------------------------------KAFLPPGEGPGLDGlcqdlldse------- 221  human
Q6NS69        191 --------------------------------------------------TAFLSMGEGLGLDSlcqdlsdse------- 213  house mouse
NP_001102790  251 KTACKNP-------------------------------------EKLTMTCASEFMQPKPILEAssleephtsetegkvv 293 
Q5JTC6        252 KMACKDP-------------------------------------EKPMEACASAHVQPKPAPEAssleephspetgekvv 294  human
3_pfamImport  217 CREAESPggpsdk--gargedAAGHLRAEKPRAAPEPgagevgtAEDASRTGDIPIKTVPLVDSecgsgra---pvlpdp 291 
Q8CCJ4        275 CLEAGSPtgsgdq--ssrgedAEGHRREEKPGAALESgagevqaAEDASKTGDVPIKTVPLVDSeggsgra----savpd 348  house mouse
1_pfamImport  213 GREAESPgaptas--gapgedAAGPRRAEDPRAPPELgagqvrtAEDTSRTGDVPIKTVPLVDSdcgsgra----savpd 286 
XP_005990615  225 -MDCGEPscmldnn-knikegIATEIKQESLALLPDTskeqiqvKEAEAITGDIPEQGTALTKPkcvsape----taape 298  coelacanth
F1QGH6        281 -STADPQSEQSVDRLCS-MFTDVTSLKSFDSLTGCGDIIADPEEDSG-----NGGSATSSGTGSSSggcmgrrlsgagtn 353  zebrafish
E1C2Q8        300 pSSVDPPSEQSIDRICL-MFADVTSLKSFDSLTGCGDIIADQEEDVGgg--sGGCEKSTPGAGKLG-------------- 362  chicken
2_pfamImport  276 -SNGDPPSEPSVDRLCSlLFTDVTSLKSFDSLTGCGDIIADAEEDG------PGGNARArapp----------------- 331 
5_pfamImport  257 -SIGDQPSEPSVDRLCSiLFTDVTSLKSFDSLTGCGDIIADADEEG------PGGNvpp--------------------- 308 
XP_007252366  281 -SSVDPPSEPSVDRLCS-MFTDVTSLKSFDSLTGCGDIIADQEEDSG-----NGGSATSSGTGSSSggcggrrvigaate 353 
Q8N944        222 ------lladasfgLCRaLCEDVASLQSFDSLTGCGEVFADESSVPSle-lnEGPESPTQAAQGLEskvp---------- 284  human
Q6NS69        214 ------flhdspfdLCSaLCEDVASLKSFDSLTGCGEIFADGSSVPSve-lkDGPESPAHSPQALDcktp---------- 276  house mouse
NP_001102790  294 tGDANPPNGPVGDQLSL-LFGDVTSLKSFDSLTGCGDIIAEQDMDSMtdsmaSGGQRANRD------------------- 353 
Q5JTC6        295 aGEVNPPNGPVGDPLSL-LFGDVTSLKSFDSLTGCGDIIAEQDMDSMtdsmaSGGQRANRD------------------- 354  human
3_pfamImport  292 sSSVDPPSDPSADRICL-MFSDVTSLKSFDSLTGCGDIIADQEEEAG-----PSCDKHAPGPGKPV-------------- 351 
Q8CCJ4        349 pSSVDPPSDPSADRICL-MFSDVTSLKSFDSLTGCGDIIADPEEEAG-----PSCDKHVPGPGKPV-------------- 408  house mouse
1_pfamImport  287 pSSVDPPSDPSTDRICL-MFSDVTSLKSFDSLTGCGDIIADQEDEAG-----PSCDKHAPGTGKPG-------------- 346 
XP_005990615  299 pSTIDPPSEQSIDRICL-MFADVTSLKSFDSLTGCGDIIADQEEEGG-----NGGDKAAPAEKGQG-------------- 358  coelacanth
F1QGH6        354 sercspakpplppqvsslasihascympahqrpraapKKPQGSGVVAYMGGGEEMASPE--------------------- 412  zebrafish
E1C2Q8        363 -------------------------------------APKKHPTMVAYQGGGEEMASPD--------------------- 384  chicken
2_pfamImport  332 ----------------------------------ppqPHPAGSGVVAYMGGGEEMASPE--------------------- 356 
5_pfamImport  309 ----------------------------------ppqQHSAGSGVVAYMGGGEEMASPE--------------------- 333 
XP_007252366  354 rcspvkpplp----pqvtsrvsispylsshqrmssspKKPQGSGIVAYMGGGEEMASPE--------------------- 408 
Q8N944        285 --------------------------------------------rgplQGSVEQLASPA--------------------- 299  human
Q6NS69        277 --------------------------------------------cgpaQGGMEQLMSPA--------------------- 291  house mouse
NP_001102790  354 -------------------------------------GTKRSSCLVTYQGGGEEMALPDdddneeeeeedeeveledeee 396 
Q5JTC6        355 -------------------------------------GTKRSSCLVTYQGGGEEMALPDdddeeeeeeeev--eleeeee 395  human
3_pfamImport  352 -------------------------------------LSKKNPSVVAYQGGGEEMASPD--------------------- 373 
Q8CCJ4        409 -------------------------------------LSKKNASVVAYQGGGEEMASPD--------------------- 430  house mouse
1_pfamImport  347 -------------------------------------VSKKNPSVVAYQGGGEEMASPD--------------------- 368 
XP_005990615  359 -------------------------------------TSKKNSNIVAYQGGGEEMASPD--------------------- 380  coelacanth
F1QGH6        413 ----GVDDADMQGLWHMLPQKDEDSPAPRRA------EpvlhhaPA---------------RLEKRPPQV----KALGLS 463  zebrafish
E1C2Q8        385 ----QVDDTYLQEFWDMLSQTEETETGGGGGggggtkT------PEglke-------nrgtEGAQNRVAV----KRGGLN 443  chicken
2_pfamImport  357 ----GVDDADMQGLWHMLPSTGDNSPALPRShqtpstTptstypPRattnaagchllsahrSADRRLPPV----KALGLS 428 
5_pfamImport  334 ----GVDDADMQGLWHMLPSAGESSPALPRQyqpsssTltstypPRsnspsal--rpsaqrSAERKAPQV----KSLGLS 403 
XP_007252366  409 ----GVNDADMQGLWHMLPQKGEDSPALPRS------DpivhhpPG---------------RQEKKHPQV----KSLGLS 459 
Q8N944        300 ----QNEASDFTRFWDSVNRSVRQQQRALLGpwl--------sgPQ---------------GTDRDQSRL----DTAGLA 348  human
Q6NS69        292 ----QNEASDFNKFWDSVNRSVQQQQRALMGpwl--------tsPE---------------GTETDQTRL----DTSGLA 340  house mouse
NP_001102790  397 evkdGEEDDDLEYLWAsaq-----------------------iyPRfnmnlg----yhtaiSPSHQGYMLl--------- 440 
Q5JTC6        396 evkeEEEDDDLEYLWEtaq-----------------------myPRpnmnlg----yhpttSPGHHGYMLl--------- 439  human
3_pfamImport  374 ----EVDDTYLQEFWDMLSQTEDQGQAPQEAaakattAletkgvPEtskd-------argvEGAKDASSV----KRRRLN 438 
Q8CCJ4        431 ----QVDDTYLPEFWDMLSQTEDQGQGTQEGaakaatAsdiklaPEtssd-------trcgEAAKDMSSV----KRRRLH 495  house mouse
1_pfamImport  369 ----GVDDTYLQEFWDMLSQTEDQGQGAPEGlakaaaAldakgaPEtskd-------trgvEVAKDVSSV----KRRRLN 433 
XP_005990615  381 ----EVDDAYLQEFWDMLPQTEESPSEQQNQatppsnPteqkkcPE---------------EAVGNTVKLldigKRSVTN 441  coelacanth
F1QGH6        464 KIPVSGSSktgk------qqpsRPSPPPVDKELQDA-PPSDEGYWDSPTPGPE---DED----STFLRRDGLLRDSCSGD 529  zebrafish
E1C2Q8        444 QIPIHLNN--------------KEEQKGREKEQHEGvPNSDEGYWDSTTPGPE---EDS----TTSIQKETLPRDSYSGD 502  chicken
2_pfamImport  429 KIPVVGAAggraakppiphahgRHAASPGEKE-----PLSDEGYWDTPTATPTatpDESg---QQRNRKTALTRDSCSGD 500 
5_pfamImport  404 KIPVVGGAgsragkpplphahgRHPVSPGEKE-----LLSDEGYWDTPSATPTatpDESg---LQRNQKIALSRDSCSGD 475 
XP_007252366  460 KIPVCGISktgk------qqsaHPSPPPTDKELHDA-PPSDEGYWDSPTPGPE---DED----NGFTRRDGLLRDSCSGD 525 
Q8N944        349 ELPLCPCRdprsg-----skasSIDTGTPKSEQPESvSTSDEGYYDSFSPGLE---EDKkeaeSPGTPAATFPRDSYSGD 420  human
Q6NS69        341 ELPLFPCRgppsg-----skasSIDTGTPKSEQPESvSTSDEGYYDSFSPGLE---EEKkeaaSPGTPAATFPRDSYSGD 412  house mouse
NP_001102790  441 -dPVQSYPnl-----------gLGELLTPQSDQQESaPNSDEGYYDSTTPGFE---DDSge-aLGLVHRDCLPRDSYSGD 504 
Q5JTC6        440 -dPVRSYPgl-----------aPGELLTPQSDQQESaPNSDEGYYDSTTPGFE---DDSge-aLGLVRRDCLPRDSYSGD 503  human
3_pfamImport  439 RIPIEPHP--------------KEEPKPVEKEQQEGvPNSDEGYWDSTTPGPE---EDS----TSGGKKSGIPRDSYSGD 497 
Q8CCJ4        496 RIPIESQQ--------------KEEPKHPEKEHQEGvPNSDEGYWDSTTPGPE---EESis-nSSSSKKVVIPRDSDSGD 557  house mouse
1_pfamImport  434 RIPIESQP--------------KEEPKHLQKEQQEGvPNSDEGYWDSTTPGPE---EDG----TGSGKKAGISRDSYSGD 492 
XP_005990615  442 S---------------------DNSDDSIEKEPQECiPNSDEGYWDSTTPGPE---EDSg---NTFVQKESLPRDSCSGD 494  coelacanth
F1QGH6        530 ALYDLYdpDSPsaa-------------------------------gsdDD--ASSPT 553  zebrafish
E1C2Q8        503 ALYDLY--AEP-------------------------------------DEnpPGGPP 520  chicken
2_pfamImport  501 HLYDLY--NDPegaged--------------------------veqegDEdlNSTPS 529 
5_pfamImport  476 HLYDLY--NDPeeege----------------------------dqrgDNdvNSTPS 502 
XP_007252366  526 ALYDLYdlDSPgag-------------------------------gsdDDdnMSSPT 551 
Q8N944        421 ALYELF--HDPsegplgpspdddlcvseslsgpalgtplsicsfrvgaEEnlAPAPG 475  human
Q6NS69        413 ALYELF--YDPseapvgpildddcvsesl-sgpalgtplsmcsfrvgaEEnlAPAPG 466  house mouse
NP_001102790  505 ALYEFY---EP-------------------------------------DDslEHSPP 521 
Q5JTC6        504 ALYEFY---EP-------------------------------------DDslENSPP 520  human
3_pfamImport  498 ALYDLY--ADP-------------------------------------DGspAVPPA 515 
Q8CCJ4        558 ALCDLY--VEP-------------------------------------EAspATLPA 575  house mouse
1_pfamImport  493 ALYDLY--ADP-------------------------------------DGspAALPA 510 
XP_005990615  495 ALYDLY--ADP-------------------------------------DEslAGMAS 512  coelacanth
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