Conserved Protein Domain Family
AbiEi_1

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pfam09407: AbiEi_1 
AbiEi antitoxin C-terminal domain
AbiEi_1 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.
Statistics
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PSSM-Id: 401383
View PSSM: pfam09407
Aligned: 8 rows
Threshold Bit Score: 105.63
Threshold Setting Gi: 502881978
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014781780   68 KLPIELYVNSlfkylernyyvglYSAAKFYGA------GHQQI-QKEYVLHDKaPLLSISKHAINLDFFtv---snWPTK 137 Aequorivita su...
WP_013116954   58 VLPDQAAVCG-------------ETAAWLHGIdarppgRHHAP-PQLQCLVPTgTARRRRPGLACREGV-------LPAD 116 Cellulomonas f...
P71625         84 YLPLRSWLardqna---gfmlagASAAWHLGY------LDRQPdGRIPIWLP--PAKRLPDGLASYVSVvripwnaADTA 152 Mycobacterium ...
jgi:Xcel_2882  83 LVTLRAFLASrghaarddvagclSTAIWLHGL------SDRAP-NRHEVAVP--PRAHVPAGLAREFRVvrfasavRP-- 151 Xylanimonas ce...
KTD28802       74 CLPPDQFIPDlmtylqipyyvglLSAAQYYGA------SHQQA-QTFQVLVPK-NRKKIQCGQIRVEFIarkniydIPTK 145 Tatlockia micd...
jgi:Geob_2872  67 CLPANQFIPAlmshlgelyyaglLTAAEHHGA------AHHRP-QSFQVIVPR-TRTGITCGGVRVDFIgrknvagMPTQ 138 Geobacter dalt...
Q3SW12         73 CLPAEQFIPDlmkrlgaayytglLSAAQFHGA------AHHRP-QEFQVMVAK-ARRTIVCGAVRVAFFvrknlsaIPVQ 144 Nitrobacter wi...
jgi:Glov_1417  66 CVPAAQFIPHlmahlgevyyaglLSAAEYHGA------AHQRP-QVFQVMVAK-VRRPITCGNIRVQFIyrknaaaIPTE 137 Geobacter lovl...
WP_014781780  138 NVls-----------kkGDAGMFKISSPCLTAVDLIYHQTKIGGLnrmlSVLEELAEE--IKLADAKELLSWYRqKSVLQ 204 Aequorivita su...
WP_013116954  117 DV---------------AMVHGVPTTSPARTALDLARYAPAFIGL----AALDAFAHAglVTPQELHLRARGLRgARNIA 177 Cellulomonas f...
P71625        153 LLaprpallvrrrldlvAWATGLPALGPEALLVQIATRPASFGPWadlvPHLDDLVAD--CSDERLERLLSGRP-TSAWQ 229 Mycobacterium ...
jgi:Xcel_2882 152 -----------------ADHDGVPVHGPATILVHLAARPTDVRSWgsveEALPDLVDR--ADRDDLAAELSAAD-AATRT 211 Xylanimonas ce...
KTD28802      146 NFn--------------TPKGYVKISSPEATALDLANYPMYCGGLsnvlTTLEELAEQ--IQPQALERLANQLPsSPQLQ 209 Tatlockia micd...
jgi:Geob_2872 139 DFk--------------TPRGYLRVSTPEVTAFDLAGYPHHAGGLdnvaTVLSELAEK--MDPAKLVSIADLSP-ISWSQ 201 Geobacter dalt...
Q3SW12        145 SFn--------------TPRGTILVSSPEATAFDLVGYQGQIGGLdqvaTVLGELAEK--LNPEKLADVAQSAP-VPWAQ 207 Nitrobacter wi...
jgi:Glov_1417 138 LRn--------------TTAGTIKVSTPEATALDVVGYVSHCAGLdnvvTILSELAES--VNPQRLAEVAELSP-VSYAQ 200 Geobacter lovl...
WP_014781780  205 RFGYLLNE 212 Aequorivita sublithincola
WP_013116954  178 RARQLLEL 185 Cellulomonas flavigena
P71625        230 RASYLLDS 237 Mycobacterium tuberculosis
jgi:Xcel_2882 212 RLGHLLGE 219 Xylanimonas cellulosilytica DSM 15894
KTD28802      210 RLGFMFEA 217 Tatlockia micdadei
jgi:Geob_2872 202 RLGYLLEL 209 Geobacter daltonii FRC-32
Q3SW12        208 RLGYLLGK 215 Nitrobacter winogradskyi Nb-255
jgi:Glov_1417 201 RLGYLLEL 208 Geobacter lovleyi SZ
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