6ICZ


Conserved Protein Domain Family
Btz

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pfam09405: Btz 
CASC3/Barentsz eIF4AIII binding
This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.
Statistics
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PSSM-Id: 401381
View PSSM: pfam09405
Aligned: 17 rows
Threshold Bit Score: 79.8413
Threshold Setting Gi: 156221345
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ICZ_XX      141 TVTGERQSG--DGQESTEPVENKVGKKGPKHLDDDEDRKNPA--YIPRKGLFFEHDLRGQTQE--------EE----VRP 204
EDO42201     187 SAESEDQGEwaSAEEDGADTK-DSGDEKTDEPPKKTDTADPA--FVPRRDTFWTHDDRWADIPdidr------------- 250 starlet sea ane...
Q8H1F3        73 DDEEESGGGidNDKS-------GVVKEAGDMNGEEENEKEKLqaAVPTGGAFYMHDDRFQEMSagg----------nrRM 135 thale cress
Q93ZJ9       103 DKTIVAGNGt------------DDSAATDLVDGEEQKKKEPF--AVPTAGAFYMHDDRFQELDaas----------nrRM 158 thale cress
Q8K3W3       138 TVTGERQSG--DGQESTEPVENKVGKKGPKHLDDDEDRKNPA--YIPRKGLFFEHDLRGQTQEeevr------------- 200 house mouse
Q17GZ3        34 TDGEEGEDDeeDDDGSDDDVIEEQETDSKRKVDDDEDRSNPQ--YIPKKGTFYEHDDRTLEDE----------------- 94  yellow fever mo...
Q9VB04        95 TDDEDDEVGseTDDGEGEQAMDRSVADSEAQKKVDEDRSNPQ--YIPKRGTFYEHDDRTAETEgei---liEPengaGQA 169 fruit fly
Q2GY83       320 SSAAAQQQPrlPQQ---------EIKRREHEEYRRKRDEDPT--FVPNRGAFFLHDHRHAGPAangfrpfpRGa--rGRG 386 Chaetomium glob...
Q7RVU7       147 SNSVTKQSRvlPHE---------QKRRSEHEEYRRKRDEDPT--FVPNRGAFFLHDHRHAGPAangfrpftRPg--rGRG 213 Neurospora crassa
XP_001796925 139 DAAPAVGAPrqPETL-------GERRRKEHEEYKKKRDADPA--FIPNRGAFFMHDQRSA-PAqngfrpagMR----GRG 204 Parastagonospor...
6ICZ_XX      205 KG------------------------------RQRKLWKD--EGRWEHDKFRE--DEQAPKSRQELIALYGYDIRSAHN 249
EDO42201     251 -----------------------------rkppSRALWDKtgD-KWLHDRYVE--EEQAPKT-AEELEESSRNLRRNAG 296 starlet sea anemone
Q8H1F3       136 RG-------------------------------GRRQWGSgeERKWGHDKFEEmnTGEKHSD--QRMSRGRFRGHGR-G 180 thale cress
Q93ZJ9       159 RG-------------------------------GRRLWQSrdERKWGHDKFEEmnTQKQQYD--RRTSRGRGRGRGQ-G 203 thale cress
Q8K3W3       201 ----------------------------pkgrQRKLWKDEg---RWEHDKFRE--DEQAPKSRQELIALYGYDIRSAHN 246 house mouse
Q17GZ3        95 EDgkagdesvnnddpag-pggdrkvdknavskATKKWQASa--DRWTHDRFDE--SEQAPKSRAELVSAYGYDIRSEDG 168 yellow fever mos...
Q9VB04       170 AAepngelnglaaaga--tptgqtpqisqaskTMRKWQPAsgGDRWSHDRFEA--TEQAPKSRAELLQTYGYDIRNEDA 244 fruit fly
Q2GY83       387 RGafgnhf------------------apisqiH--NVPDPviNGLWKHDMHEVvaAPQPPRQN--RYLPSNEGLPNGNG 443 Chaetomium globo...
Q7RVU7       214 GGrggglvg-----------------pftsvnPPSNPSDPttSGPWAHDMHEEvaGPRPQRQQPPRYMPDDEGPPNGNG 275 Neurospora crassa
XP_001796925 205 RGggiggpfspakyvpnrngphvgarhtndsvSMRPPQNEatDSPWQHDLHETvnAPGGPAQ--------SVQPPNGPM 275 Parastagonospora...
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