Conserved Protein Domain Family
Btz
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pfam09405: Btz (This model is not part of the current CDD release)
CASC3/Barentsz eIF4AIII binding
This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.
Links
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Statistics
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PSSM-Id: 490350
Aligned: 14 rows
Threshold Bit Score: 77.9943
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAK40875     131 KGELGQQTGRTPSAPPAEPKQDslTERRRRDNEKYTKEKEENPA--FVPTRGSFFLHDKRSTDNAANGHKP------FAK 202
Q0CBH7       131 KGTSGLPTGRTPSAPPTEPKRDtvADRKRREPEKGPKDRDENPA--VVPTRGSFFLHDKRSTESASNGHKS------SSR 202 Aspergillus ter...
XP_001541376 130 KEGLDSSIATPKSANNKGHRGEtfAERKRRELEKYIKERDSNPA--FVPTRGGFFLHDKRNAGSPPNGYRSphntngNGK 207
Q8H1F3        73 DDEEESGGGIDNDKS---------GVVKEAGDMNGEEENEKEKLqaAVPTGGAFYMHDDRFQEMSAGGNR---------- 133 thale cress
Q6I5G3       106 AVAAAGEEAGM---GMKGEAEGeaSAAAAEG---EEGKKGSEPY--AVPTAGAFYMHDDRFQEARGHGRQR--------- 168 Japanese rice
Q93ZJ9       103 DKTIVAGNGT--------------DDSAATDLVDGEEQKKKEPF--AVPTAGAFYMHDDRFQELDAASNR---------- 156 thale cress
XP_001634264 187 SAESEDQGEWASAEEDGADTK---DSGDEKTDEPPKKTDTADPA--FVPRRDTFWTHDDRWADIPDIDRRKp-------- 253
Q8K3W3       138 TVTGERQSG--DGQESTEPVEN--KVGKKGPKHLDDDEDRKNPA--YIPRKGLFFEHDLRGQTQEeevr----------- 200 house mouse
1_pfamImport   1 DAAPAVGAPRQPETL---------GERRRKEHEEYKKKRDADPA--FIPNRGAFFMHDQRSA-PAQNGFRP------AGM 62 
Q2GY83       320 SSAAAQQQPRLPQQ-----------EIKRREHEEYRRKRDEDPT--FVPNRGAFFLHDHRHAGPAANGFRP------FPR 380 Chaetomium glob...

CAK40875     203 S-KSRPYG------LIVDGNVrnsftgea-irtstltaCRNQVKSDASENKWTHDLHDTVAGDDAPVSKVPAVPATVPTY 274
Q0CBH7       203 T-KSRPYG------LIVDGTI------------------RRDTAKPASEGVWTHDLHETVAGDDPPTVKPT--PTSTFNN 255 Aspergillus ter...
XP_001541376 208 L-KTRPYG------LIVDSNAa----------------RRPAPKPDVTVGQWAHDLHDSIVQDTRPV------PSTSATI 258
Q8H1F3       134 ----RMRG-------------------------------GRRQWGSGEERKWGHDKFEEMNTGEKHSD--QRMSRGRFRG 176 thale cress
Q6I5G3       169 ----RMVG-------------------------------DRRLWNAKEDQAWVHDRFDEMNLHDFHNDYTRRRPRGRFRG 213 Japanese rice
Q93ZJ9       157 ----RMRG-------------------------------GRRLWQSRDERKWGHDKFEEMNTQKQQYD--RRTSRGRGRG 199 thale cress
XP_001634264 254 --------------------------------------pSRALWDKTGD-KWLHDRYVE--EEQAPKT-AEELEESSRNL 291
Q8K3W3       201 ----------------------------------pkgrQRKLWKDEG---RWEHDKFRE--DEQAPKSRQELIALYGYDI 241 house mouse
1_pfamImport  63 R--GRGRGggiggpFSPAKYVpnrngphvgarhtndsvSMRPPQNEATDSPWQHDLHETVNAPGGPAQ--------SVQP 132
Q2GY83       381 GaRGRGRGafg-nhFAPISQI-----------------H--NVPDPVINGLWKHDMHEVVAAPQPPRQN--RYLPSNEGL 438 Chaetomium glob...

CAK40875     275 PPKPV 279
Q0CBH7       256 PPKQV 260 Aspergillus terreus NIH2624
XP_001541376 259 SNTTS 263
Q8H1F3       177 HGR-G 180 thale cress
Q6I5G3       214 RGG-A 217 Japanese rice
Q93ZJ9       200 RGQ-G 203 thale cress
XP_001634264 292 RRNAG 296
Q8K3W3       242 RSAHN 246 house mouse
1_pfamImport 133 PNGPM 137
Q2GY83       439 PNGNG 443 Chaetomium globosum CBS 148.51
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