2J0U


Conserved Protein Domain Family
Btz

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pfam09405: Btz (This model is not part of the current CDD release)
CASC3/Barentsz eIF4AIII binding
This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.
Statistics
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PSSM-Id: 518883
Aligned: 15 rows
Threshold Bit Score: 77.145
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J0U_T         5 TVTGERQSG--DGQESTEPVEN--KVGKKGPKHLDDDEDRKNPA--YIPRKGLFFEHDLRGQTQEEE-----------VR 67  human
XP_001541376 130 KEGLDSSIAtpKSANNKGHRGEtfAERKRRELEKYIKERDSNPA--FVPTRGGFFLHDKRNAGSPPNgyrsphntngnGK 207
Q8H1F3        73 DDEEESGGGidNDKS---------GVVKEAGDMNGEEENEKEKLqaAVPTGGAFYMHDDRFQEMSAGgn----------- 132 thale cress
Q93ZJ9       103 DKTIVAGNGt--------------DDSAATDLVDGEEQKKKEPF--AVPTAGAFYMHDDRFQELDAAsn----------- 155 thale cress
EDO42201     187 SAESEDQGEwaSAEEDGADTK---DSGDEKTDEPPKKTDTADPA--FVPRRDTFWTHDDRWADIPDIdrr---------- 251
Q8K3W3       138 TVTGERQSG--DGQESTEPVEN--KVGKKGPKHLDDDEDRKNPA--YIPRKGLFFEHDLRGQTQEeevr----------- 200 house mouse
Q9VB04        95 TDDEDDEVGseTDDGEGEQAMD--RSVADSEAQKKVDEDRSNPQ--YIPKRGTFYEHDDRTAETEGEi---------lIE 161 fruit fly
1_pfamImport   1 DAAPAVGAPrqPETL---------GERRRKEHEEYKKKRDADPA--FIPNRGAFFMHDQRSA-PAQNgfr------paGM 62 
Q2GY83       320 SSAAAQQQPrlPQQ-----------EIKRREHEEYRRKRDEDPT--FVPNRGAFFLHDHRHAGPAANgfr------pfPR 380 Chaetomium glob...
Q7RVU7       147 SNSVTKQSRvlPHE-----------QKRRSEHEEYRRKRDEDPT--FVPNRGAFFLHDHRHAGPAANgfr------pfTR 207 Neurospora crassa
2J0U_T        68 P---KGR---------------------------------QRKLWKD---EGRWEHDKFRE--DEQAPKSRQELIALYGY 106 human
XP_001541376 208 L---KTRpygliv----------------------dsnaaRRPAPKPdvtVGQWAHDLHDSivQDTRPV------PSTSA 256
Q8H1F3       133 -----rRmr-------------------------------gGRRQWGsgeERKWGHDKFEEmnTGEKHSD--QRMSRGRF 174 thale cress
Q93ZJ9       156 -----rRmr-------------------------------gGRRLWQsrdERKWGHDKFEEmnTQKQQYD--RRTSRGRG 197 thale cress
EDO42201     252 --------------------------------------kppSRALWDktgD-KWLHDRYVE--EEQAPKT-AEELEESSR 289
Q8K3W3       201 ------------------------------------pkgrQRKLWKDe---gRWEHDKFRE--DEQAPKSRQELIALYGY 239 house mouse
Q9VB04       162 PengAGQaaaepngelnglaaag--atptgqtpqisqaskTMRKWQPasgGDRWSHDRFEA--TEQAPKSRAELLQTYGY 237 fruit fly
1_pfamImport  63 R----GRgrgggiggpfspakyvpnrngphvgarhtndsvSMRPPQNeatDSPWQHDLHETvnAPGGPAQ--------SV 130
Q2GY83       381 Ga--RGRgrgafgnh------------------fapisqiH--NVPDpviNGLWKHDMHEVvaAPQPPRQN--RYLPSNE 436 Chaetomium glob...
Q7RVU7       208 Pg--RGRgggrgggl-----------------vgpftsvnPPSNPSDpttSGPWAHDMHEEvaGPRPQRQQPPRYMPDDE 268 Neurospora crassa
2J0U_T       107 DIRSAHN 113 human
XP_001541376 257 TISNTTS 263
Q8H1F3       175 RGHGR-G 180 thale cress
Q93ZJ9       198 RGRGQ-G 203 thale cress
EDO42201     290 NLRRNAG 296
Q8K3W3       240 DIRSAHN 246 house mouse
Q9VB04       238 DIRNEDA 244 fruit fly
1_pfamImport 131 QPPNGPM 137
Q2GY83       437 GLPNGNG 443 Chaetomium globosum CBS 148.51
Q7RVU7       269 GPPNGNG 275 Neurospora crassa
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