Conserved Protein Domain Family
MSC

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pfam09402: MSC 
Man1-Src1p-C-terminal domain
MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands.
Statistics
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PSSM-Id: 490347
Aligned: 107 rows
Threshold Bit Score: 187.887
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007395716 397 LLGTSVLTALGmYKTESASIGFCETGK-------------------------NTNDILEGmkvrrtaiqecnrenrttlf 451 
XP_003959028 289 IIALPILFALW-YREQRIRVGYCGKELpliplas------------grtdnvFFQKIDSL-------------------- 335 
XP_022463639 376 AIASVVLWGVW-YREQRIAVGFCHHELplkklcpdrliqiyqtfvldlsffdSI-------------------------- 428 
Q6FMP6       278 VIVLPILFFLW-YREQKIRVGFCGHEL-------------------------PVAKFAPYansnkvw------------- 318  [Candida] glab...
XP_056087078 331 SILLPILFGLW-YREQRIRIGYCGHEEpiksla--------------fsafsQTARVDEF-------------------- 375 
XP_003676977 487 MFAVPVVFALW-YREEQIAIGYCNTRYelnntgttseh------------------------------------------ 523 
XP_003671605 567 LFAIPIVFALW-YREERILVGYCGHESvqsils-------------lsiespFFSCLDTI-------------------- 612 
XP_004180860 510 sILLPILFLIW-YREQKLATGYCGYSL-------------------------SPPSIIHSksnvfsqm------------ 551 
XP_001646758 331 SIIATIGFTLW-YREQRILVGYCGHEVerklavd-----------tllesnqMATKVKSF-------------------- 378 
XP_011273519 625 FFTILIISSLW-YREQRILIGYCGLEIndktfp--------------ntdneILIKIDEFl------------------- 670 
XP_007395716 452 lahpdaaqdvpspqptqvatgtegsnvilseacpPPPLLPlprpeTCQLCPEHASCT-PTTVTCENGYLLR--PHPLLsf 528 
XP_003959028 336 ----------------------------------LKFVKP-----KCLPCPSNAKCYsLMDMDCYPQFKRY--SSIFK-- 372 
XP_022463639 429 ----------------------------------LEKYAP-----KCIDCPENAMCFsHMRLICDAGYIAM--SSWKS-- 465 
Q6FMP6       319 ----------------------------asvdktLERFLP-----KCKLCPEGAICKtHLQMSCKDGYVLR--KSWWN-- 361  [Candida] glab...
XP_056087078 376 ----------------------------------LQAYAP-----NCLECPEHATCSsLMNIECESGYELK--SSILE-- 412 
XP_003676977 524 ------------------------helwnilgtyLEATKP-----KCIPCPEHASCYaNMQLICDNNYERT--TNYLS-- 570 
XP_003671605 613 ----------------------------------LSPFKP-----KCLPCPANAICHsNLATECIPHYETSafSSLLS-- 651 
XP_004180860 552 --------------------------ifkfdawlKQKFSP-----SCVSCPKNALYTfNMNANCQSGFEFT--YSFFN-- 596 
XP_001646758 379 ----------------------------------LENYKP-----QCIPCPENGKCHsLMRLDCNENYLLA--NNPLS-- 415 
XP_011273519 671 ----------------------------------DQNLKP-----TCLEAPENSIALpYLQIKCKPDYIVY--QPWYK-- 707 
XP_007395716 529 lpipsslrptdnrnaytnpslavaptygnkspldlaytglslimdgLPGLGPVafPPRCVE-DPMRKRHIGAMGRTIDSK 607 
XP_003959028 373 ----------------------------------------------LNGLIPL--TDYCII-DNTKEKLVNKMVNYMLKK 403 
XP_022463639 466 ----------------------------------------------LNGLLPI--NGHCIK-DMKKDEILKDIFQSCLED 496 
Q6FMP6       362 ----------------------------------------------LESLLPL--ADKCIT--KRKAANKKTPLLFALDL 391  [Candida] glab...
XP_056087078 413 ----------------------------------------------TYGVIPF--SKYCVK-DESKEKEVDELVWKVSEY 443 
XP_003676977 571 ----------------------------------------------LFKLIPL--ADSC---HEASAERVLEIANHLTDV 599 
XP_003671605 652 ----------------------------------------------LYGLIPL--PPSCEPiETEKSKELNQITSELLSV 683 
XP_004180860 597 ----------------------------------------------FYGLIPM--RRHCEK-MKLDTKKLNKILTNIMAI 627 
XP_001646758 416 ----------------------------------------------LFGLIPI--SGECIR-DTKMEKIRNKIVRNALAI 446 
XP_011273519 708 ----------------------------------------------IHGLLPF--SDYCIK-DTKKELIIKEVVSKSLEL 738 
XP_007395716 608 LAAERGRRLCDGARPDDkpgkvaqeakKWGVEVDALKESIRKdvikkSKSPS-QLLSTLDDT---FNEAIQQLVEWGGVF 683 
XP_003959028 404 LRSKNGSVDCGTAKSDL----------ISGMIEDDLYDSIYE-----KFSNK-YSDDEFEEL---WSEALDKLEDLKEI- 463 
XP_022463639 497 LRMENAEKNCGEGENNL----------ESGISSSILFEKHFRkviedQN----WSTYEGKQL---WGTVLDKLKGMPEVS 559 
Q6FMP6       392 LRTQNANTHCGSTLPDNy---------QAGMLEKDLFNNVYE-----EYRDM-MTKESFEKE---WAVLSNSLKRLPEIY 453  [Candida] glab...
XP_056087078 444 LRKKNAQVDCGEGQNLF----------ESGETETKLYEIFSR-----SRPSW-ENQADFNEH---CRNVIEKLRHMDEIV 504 
XP_003676977 600 LRKQNARIQCGKGANDL----------KSGLSEKHIFNLLSL-------WYTwVHEENFDDL---WLNVQSELKKKPDIS 659 
XP_003671605 684 LHHQNAHLECGNSADNG----------LSGMNEGELYNEFMS-----YRSPW-INKEQYSEL---WVRVKAKLKNSKDIE 744 
XP_004180860 628 LTKKNTEaiyf------------lnsnYVTFSKDDLYEFLLGryfndGK-----------EVdiyFETVVKSLKNNPDIV 684 
XP_001646758 447 IRKKNAVYQCGSSNDDL----------ASGIRVVELYNLFRQ-----NKYSW-LNKKEFDEM---WKEVITNLKKIPDVI 507 
XP_011273519 739 LRIKNANVQCGDCTNDE----------IVGITNDELYEFFFN-----SKSNS-ITDEEFNEL---WVNVLKDLQNEPEIT 799 
XP_007395716 684 IGEDEQG----------------------------HRYVAHRTPKLDMMCAVK-------VKALEYRDMWWKQ---AFGS 725 
XP_003959028 464 --KISVTdiig--------------------pdqmKIIRSTSKKSIGLKCRLGspllknfRDVLSTCIKLRYV---TAII 518 
XP_022463639 560 WSYREDElv-------------------------gINLRSHSRKYIGFGCRYG-------RHIKNTVMTYQHH---LIGL 604 
Q6FMP6       454 YKTFVSKnvagn-------------------ieniQLFRSLSKQNVSYFCGIF-----------KLLKEFPIEknvLFVA 503  [Candida] glab...
XP_056087078 505 WLPLDFEtgeeihf---------------kpnnttCVYRSTSKKWVKLPCHLG-------ADIRKGLRKYGVS---VLIT 559 
XP_003676977 660 FSVVPVEnst----------------------nstLWLRSNSRRYINLKCFFQ---------PTENIMKQSRY---IFVL 705 
XP_003671605 745 WHYIHPYsngslptn------------stsnteivTQFRSHSKKYVRVTCSLP---------KIEILPKLEEAlysVAFL 803 
XP_004180860 685 WKEVEDLsgsk--------------------ydkhNNVTISAVEEVFYSTKTN-------FPGFNYLFKNKLApflLMLI 737 
XP_001646758 508 WIRNMNAnnihsnd---------------vsnyftGILRSTSGKYLNLSCRLE-------KNMIDLGLKVSGI---LVGV 562 
XP_011273519 800 LRYTDIVdsnstqdnlstnevedetddiqqttersIIFRSNSKLKLSIKCKFQ-------KEIYDNFEKNKKI---LISF 869 
XP_007395716 726 ----LALLLSA----WMAKHRRKQRLEDRERVTVLVDTVYDMLRNQELVHHTDPVSAPr-pYVPSTQLRDAVLQGEHSVA 796 
XP_003959028 519 ----AIFGIIS----FFTFKYTRKCLTRRKLITFYTEKAIEKLK--KAKRTRNNSS-----GLDTLQIRDDVLSEVTNLK 583 
XP_022463639 605 ----IVALLVF----IIVKKRVKSYKIEQDKIRLYTENAIDRLKKSKLENNDPP-------FVHTVQLRDVILADVADLH 669 
Q6FMP6       504 ----LTIFSCTvtleIILQKLWKCQNRENAFVEKSTEKALEKLREASRD--------PevkFLDTVQLREFLLSETTNLK 571  [Candida] glab...
XP_056087078 560 ----LIVILFI----KKIQSTLDDYVQGEQIIEQFVKEATDRLKSAKKNEDEEP-------FLTTVQLRTILLRDIPNIK 624 
XP_003676977 706 ----LLLIFIIyglwNYVHGIFERRHGDAANIEQLFVTTLRLLQDAKKE--------KdmpFVNTLQIKDQIFKDIKDMR 773 
XP_003671605 804 ----ILLFITI----KVAKNEWTRRLKEQSYIRNLIKIAIQELKVNKREQIESP-------FVNVLTIKSKLLNDISDAD 868 
XP_004180860 738 lsplLYIIITI----FLITLVSYKTYLTRKKVQHIVQRVVIDLKSA---KRSDNSLD----YRNTTQIKELIFEEEKDMK 806 
XP_001646758 563 ----TLFLLLI----NKARKYFSYYVSEKSNIEDAIQILLLELKKHSDEKEYN--------TLTTGQLRALIFDETTDLK 626 
XP_011273519 870 ----LTISILI----LIGYNKIKSIQKRNLKIKEISDIILIKLQKQSKNSQLDSTGLTk-rFLSNIQLRDELLINYHN-K 939 
XP_007395716 797 TRQRLWKEVERIV--EANTNVRTNLEEvAGGDEMRVWRWVGS 836 
XP_003959028 584 DKNYFWSQMMKRMd-ADEKNIASTQIE-VHGEIIKYWNWIGN 623 
XP_022463639 670 ERNEIWGSMVKRM--DKDKNVLSSQME-IHGEIMRCWMWTGD 708 
Q6FMP6       572 KKNQLWDKISSKL--LENENVEKRQME-LYGEVLGIWEWNd- 609  [Candida] glabrata
XP_056087078 625 EQNSLWARTKDKIikEYSENIELYLLE-ENGEIMTCLEWNd- 664 
XP_003676977 774 TRLNLWKKVSAKLe-EDKKQIKVYHLE-VDGEIMECWEWIDP 813 
XP_003671605 869 YKNYVWKEIKQKI--EQNPNVLTYHTE-LQGEIMKCWEWVGQ 907 
XP_004180860 807 TLRNLWKLIRLEL--SNYLEVTNYIKE-QDGEIIECWEWdsn 845 
XP_001646758 627 HQNQMWKQICARLe-KDYKNVDTEQME-IHGEIITRWRWVDi 666 
XP_011273519 940 EKFKIWELILNNL--EKNSNIRILTKE-IHGEIVKVLEWIGd 978 
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