2GIA


Conserved Protein Domain Family
MRP

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pfam09387: MRP (This model is not part of the current CDD release)
Mitochondrial RNA binding protein MRP
MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilises them in an unfolded conformation suitable for RNA-RNA hybridisation. Each MRP subunit adopts a 'whirly' transcription factor fold.
Statistics
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PSSM-Id: 518873
Aligned: 7 rows
Threshold Bit Score: 167.453
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GIA_A         4 SSSDADGKEVGSsgegnratggkwrrpSLAQQRARR----AQLPPAFDVVHWNDEDISRG-------------------- 59  Trypanosoma bru...
1_pfamImport   1 ARAAGDGPAGDG---------------AARLTKQRS----SAHRSAFSIHHSSRKVLSSAvshggsgtvqasaclrppvl 61 
2_pfamImport   1 FTA-GDGPDTEGhayarnt--asvkdrASRTVKQHR----STSKPAFNINHMSRKATSSAvsqsschslqgnmalrppvl 73 
XP_003721918  18 SVRFQSSSALPAmnqnr-------------rsqnRRnfisTNSLPKFEI-HDVRDDPEHG-------------------- 63 
Q4QHR3        47 SSDAVaptsnnaq-------rnnsrnsSMQSQRGRR----DAMPPAFDIVHWNDEDIAAG-------------------- 95  Leishmania major
Q4DWJ0        36 SEAPADSNAKHDtntsgsa--srwrrlSASQLRARR----PQLPPAFDVVHWNDDDMSSG-------------------- 89  Trypanosoma cruzi
XP_023510831  62 ACATEEGQAGDApscpssa--aslrdrAARTAKQRR----SASKLAFSVNHASGKAVSLAvgrrgsgglqgaaclqppvl 135
2GIA_A        60 --HLLR-VLHRDTFVVLDyhrqa---rmltEEG--------------NKAERVvs--vMLPAVYTARFLAVLEGR---SE 114 Trypanosoma bru...
1_pfamImport  62 deSLIReQTKVDHFWGLD------------DDGdlkggn---kaaiqGNGEVAae--aAGSNGYMCSECSLLAERkgaLT 124
2_pfamImport  74 deSLIReQTKVDHFWGLD------------DDSdlkeplggskaalqGNGDLAtvadtATVNGYTCSNCSLLSERkdvLT 141
XP_003721918  64 --SMTR--VSVDGKQLLvsq--------fpQLGprkadp--ndttpqFDRDRRis--mRFRHIDLAGFVSVVENR---IS 124
Q4QHR3        96 --HLLR-VVHRDGFIVLDyhrqrcataelrEDGsra--------anpNRAERVvt--vTLPPVYVARFLGVLEGR---MS 159 Leishmania major
Q4DWJ0        90 --HLLR-VLHRDSFVVLDyhrqv---kklgEEG--------------NKAERVvs--vMLPAVYTARFLGVLEGR---LD 144 Trypanosoma cruzi
XP_023510831 136 deSLIReQTKVDHFWGLD------------DDGdlkggs---eaavqGNGDLA-----ARSNGFTCRDCSLLSGRedaLT 195
2GIA_A       115 KVEVHSRYTNATFTPNPAAP----------------------------------------YTFTLKCTSTRPAQQKQQV- 153 Trypanosoma bru...
1_pfamImport 125 ACSAAHGPVSRIYSRDRHQKrraagcgdgiwslavrtsascasflvqlfqvvlmklnyasENYKLKSCESKSYESESHEs 204
2_pfamImport 142 AHPTARGPTSRVYSRDRSQKr----------------------------------------------------------- 162
XP_003721918 125 SHHVKNNAFDMAFEKTT-------------------------------------------NGYVLK--------GQVHRs 153
Q4QHR3       160 KLEVQSRFTNASFSPNAAKGk---------------------------------------HHYTLRCTSMKPTTGQIQTv 200 Leishmania major
Q4DWJ0       145 KVEVQSRFTNAVFAPDPAVP----------------------------------------HTFILNCTSTRPPQQQQQQn 184 Trypanosoma cruzi
XP_023510831 196 TLPVAHGTSSRVYSRDRTQKrgasfcvdriwwlakytsssfssflvqlfqvvlmklnyesENYKLKSYESKDRESESYKs 275
2GIA_A       154 -A------------------------------------------------------------------------------ 154 Trypanosoma bru...
1_pfamImport 205 kAhsshcgrmdasmrlaedghlrangaslcdeckgrkhlethvstrsrpgglagtlglalsragqlsgqalhragaagwr 284
2_pfamImport     --------------------------------------------------------------------------------    
XP_003721918 154 nS------------------------------------------------------------------------------ 155
Q4QHR3       201 dG------------------------------------------------------------------------------ 202 Leishmania major
Q4DWJ0       185 gG------------------------------------------------------------------------------ 186 Trypanosoma cruzi
XP_023510831 276 kSrestahssycgrvnvtelfredgrlgvhgeslc-----------------------------rllmqtlrrigaagwf 326
2GIA_A       155 ----------------GEEGDETFEWT----VEFDVAESLMLQRFLTQALHYNTG 189 Trypanosoma brucei brucei TREU927
1_pfamImport 285 vsrtllsvlclataapGKAASEVFWWLgigwYQFVTLISWLNVFLLTRCLRNICK 339
2_pfamImport 163 ----------------RKAASGVFWWLgfgwYQFVTLMSWLNVFLLTRCLRNICK 201
XP_003721918 156 --------------------QANEEWA----VRFENQFAVTMEHFLESALTESFG 186
Q4QHR3       203 ----------------ADVHEETVEWT----VEFDAAESLMLHRFLTQALHYNTG 237 Leishmania major
Q4DWJ0       187 -----------------NGEEEKFDWT----VKFDVAESLMLHRFLTQALHYNTG 220 Trypanosoma cruzi
XP_023510831 327 vlkavlsvvwlavvapGKAASGVLWWLgigwYQLVTLISWLNVFLLTRCLRNICK 381
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