4ECG


Conserved Protein Domain Family
Peptidase_M75
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pfam09375: Peptidase_M75 (This model is not part of the current CDD release)
Imelysin
The imelysin peptidase was first identified in Pseudomonas aeruginosa. The active site residues have not been identified. However, His201 and Glu204 are completely conserved in the family and occur in an HXXE motif that is also found in family M14.
Links
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Statistics
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PSSM-Id: 490324
Aligned: 45 rows
Threshold Bit Score: 93.2896
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4ECG_A        44 ALPTY-----KDXLTK-XTAYKNAVDKFI--ASGSK---------------NDLADACDAWRAVRVPWEQSEAFLF-GVA 99  Parabacteroides...
WP_011719027 150 AAARY-----HQFVVGqVQALVTGTATFC--AAVKA---------------GDLAAARRAYPAARWHYEAIEPVAE---- 203 Acidothermus ce...
Q82AX9       138 AVAAY-----REYAQEqADETLPKAEAFA--KAVKA---------------GDIEAAKKEFATSRLGWERTEPVAE---- 191 Streptomyces av...
WP_011690101 168 GTAQY-----VAYVKDqTEQLLAGTKKFA--EAYAS---------------GDAATAKNLYAATRMHWERIEPVAE---- 221 Arthrobacter sp...
Q6ADY0       152 AVTNY-----TGYVKDqAGQLLSATQTFA--AAYEA---------------GDDTAARAQYPAARQHYERIEPTAE---- 205 Leifsonia xyli ...
WP_012093212 156 ALAEY-----QIYLTTeVAEFQKSVSALS--TAIAS---------------GNLEAAQTAYGPAREAYARIAPVSE---- 209 Brucella/Ochrob...
WP_011748029 146 PLSEY-----RVYLVMqGNAAVKAAEALR--DAITA---------------NDLEAAREAWHQARLPYRRIEPLAY---- 199 Paracoccus deni...
2_pfamImport   1 GIKDYllgqtRALVTA-TADLQTASNRYYdlAQATNfdyaslwqnqqreviAALNAAREAWITASPIYEKMEGIVAg--- 76 
Q2S9N7        67 ATERH-----DAALHA-IEKLNRGLQQFI--SAPTP---------------ESLSEAREDWLQAHTALQELKVWGQ-LPA 122 Hahella chejuen...
Q21NX0        56 GSQIL-----NQSLSA-TQALNSAITTLL--NTPSE---------------DALLQAQKAWATAAITYQEFNVFAQlQPQ 112 Saccharophagus ...

4ECG_A       100 dla------qlDPSLDSWPL-DKNGIEEIIATge-------------fsKISgaVDEDAEDg-------PQNLRGFHTAE 152 Parabacteroides...
WP_011719027 204 ---------------------SFGDLDPAIDAr------------------LddVADP------------AEWTGFHRLE 232 Acidothermus ce...
Q82AX9       192 ---------------------SFGDIDPKVDVr------------------EdgLEDGQDP--------ATDWTGWHRLE 224 Streptomyces av...
WP_011690101 222 ---------------------SFGDLDPKLDAr------------------EadLAEG------------EEWTGWHRAE 250 Arthrobacter sp...
Q6ADY0       206 ---------------------QFGDIDPALDLr------------------EadLEQG------------QSWTGWHRIE 234 Leifsonia xyli ...
WP_012093212 210 ---------------------AFSDLDTAINAr------------------AdyFEKR-EQ--------DPAFGGLHRIE 241 Brucella/Ochrob...
WP_011748029 200 ---------------------RFSDLEERIDAr------------------AayLAGR-EQ--------DPAFIGYHRIE 231 Paracoccus deni...
2_pfamImport  77 -----------TPALAQF----DVDLDAGAAGs---------------eDPEnaVSFDLVLpdgrt--lpkpgNLFGVTE 124
Q2S9N7       123 aks------ylNHKMSGAPYtRASLLDAAPLLggyldevpgypksgltyAEDleLDNATLSeqhqfadeYYLVYGMHPIE 196 Hahella chejuen...
Q21NX0       113 nsvlfntvadnHYRIAAHPI-QPGYLDSFGDYqysg----------ivhDISmpLNKATLLnqhgmtdlADAALGFYAIE 181 Saccharophagus ...

4ECG_A       153 KXLFLDGep------------------rDLETSPFak--------neLEYLK-LVSERXLSDTQDLYNGWLkglgt-sdv 204 Parabacteroides...
WP_011719027 233 KALWQDDs---------------------------------------LAGMT-AVADRLQSDVRTLADLVAtq------- 265 Acidothermus ce...
Q82AX9       225 KSLWQDKk---------------------------------------IGDREkKLADQLVTDLTDWQKRVGka------- 258 Streptomyces av...
WP_011690101 251 KDLFPPAgfq----------------------------------plaAAERE-KLAAQLVADTEELAQRTRtv------- 288 Arthrobacter sp...
Q6ADY0       235 KDLWAPAghv----------------------------------psnAADRK-RLGDRLVSDTQRLYDLVYak------- 272 Leifsonia xyli ...
WP_012093212 242 YGLFEQKs---------------------------------------VDGLA-PVAGKLEQDATALKERIRgl------- 274 Brucella/Ochrob...
WP_011748029 232 YGLFAENr---------------------------------------TEGLA-PFADALVADLTELAARLKqa------- 264 Paracoccus deni...
2_pfamImport 125 STLWGTDpafaapvsadwngdgtiefgeTLPDANV------------LKASA-DLLAQMANDLDSTAQNWTp-------- 183
Q2S9N7       197 FMLWSHNd-------------------pAQQSTRFivnaappdterrRELLR-LQGERLLQDMTELAAAWRppsgsiflk 256 Hahella chejuen...
Q21NX0       182 YMLFGYQn--------------------TRTIKDY------------IAHLE-LTSAHQTHGYQNLEETPN--------- 219 Saccharophagus ...

4ECG_A       205 pSSYAEAXKkhdgsaysignvyqAIE--LXLngnNGXAGISNEVGSAKITdpVTAwngsnkdatdpNNPGVLAVESWYSW 282 Parabacteroides...
WP_011719027 266 ---------------------tyQPA--QIA---NGAVELLDEIARSKVT----------------------GEEERYSH 297 Acidothermus ce...
Q82AX9       259 ---------------------eiTPS--SMA---NGAKELLDEVATGKVT----------------------GEEDRYSH 290 Streptomyces av...
WP_011690101 289 ---------------------elTAD--KLG---NGAKELLDEVATGKVT----------------------GEEEIWSH 320 Arthrobacter sp...
Q6ADY0       273 ---------------------gfSLTldQIS---NGASSLMEEVAGSKIT----------------------GEEETFSH 306 Leifsonia xyli ...
WP_012093212 275 ---------------------riSPD--RMM---AGTASALNRFASTASD----------------------AGEDRYAH 306 Brucella/Ochrob...
WP_011748029 265 ---------------------plDPGllIEI---PGESAL--QIAQGQIP----------------------QGENLYAG 296 Paracoccus deni...
2_pfamImport 184 --TESDAFT--------------ALV--VMV---PTMSEYFASWRDSRF-----------------VLGDASTQRDFNVI 225
Q2S9N7       257 gKSMSQME---------------AVR--EAN---PWLIALIDFIDREVVGalKPKd----------GEPGWRFQEHLEFS 306 Hahella chejuen...
Q21NX0       220 -NRRRLLLQl-------------QND--ILL---EDMRYQADYWQSPALS------------------------NEWLTL 256 Saccharophagus ...

4ECG_A       283 NSLDDYKN-NIVSIKNAYfggrdldeesasESSLHALTKXI-NP--T----LDSLXVVQIDKTIDAINAI-GY-PFR--- 349 Parabacteroides...
WP_011719027 298 TDLYDIDA-NLAGSKAAF-------------QAVEPILRER-DP--A----LATTIDARFADVEAALRPL-AR-GTGwv- 353 Acidothermus ce...
Q82AX9       291 TDLSDFKG-NVEGAQKAY-------------ELLKPVAKEN-DA--A----LATELDKQFTALNTLLDKY-RTdKTSydf 348 Streptomyces av...
WP_011690101 321 TDLWDFQA-NVDGARIAF-------------ENLKPVLAQK-DP--E----LSKSLDTKFAALQAELKTH-AK-GDGfa- 376 Arthrobacter sp...
Q6ADY0       307 SDLWDFAA-NVEGAQVAY-------------ETVRDVLVEKgDAgkA----MAKKLDAEFAAIGKLLSRY-AS-GEGya- 365 Leifsonia xyli ...
WP_012093212 307 TDLQALSG-LLEGSGKTA-------------DVLRPIVMKA-DP--K----AFEGIDKDAASIRKLLGTS-AE-GNGyk- 362 Brucella/Ochrob...
WP_011748029 297 NDLQDLAA-SLEGIGKLA-------------GLLRQVVAGV-DP--A----LDKVIEQDMQAAEAHLAAIa---AEAhp- 351 Paracoccus deni...
2_pfamImport 226 SRLADIQD-ILSGLEVVY-------------AQVRPRVEAV-DP--A----QAEQIATGLRDLRAFVADIyTQeRNG--- 281
Q2S9N7       307 QDAAHFWRgRMKAMQPFL--------------------TEP-AL--F----TDAQTRNSLKELRLKLEGC-LT-ALS--- 354 Hahella chejuen...
Q21NX0       257 SPKQHYSV-VVHAFKQSA------------SSLLLEVIEAA-KS--SqqaaGASPDRVTRDRVKMSLSSLkHA------- 313 Saccharophagus ...

4ECG_A       350 ---NNLGDTEHINTATE-AC---ADLTTGLGVV 375 Parabacteroides distasonis ATCC 8503
WP_011719027 354 -syEAVDAATRRNLAQRi-----DALAEPLSRV 380 Acidothermus cellulolyticus
Q82AX9       349 tsyDKVGKADRKELSDAv-----NALAEPLSKL 376 Streptomyces avermitilis
WP_011690101 377 -yyNELSPEQVQRLAALv-----DSLGEPLSNL 403 Arthrobacter sp. FB24
Q6ADY0       366 -syTQLSTAQVKELSDKv-----NALSEPLSQL 392 Leifsonia xyli subsp. xyli
WP_012093212 363 -ayDALSSDEKTKIKEGa-----AQLAAQFTKL 389 Brucella/Ochrobactrum group
WP_011748029 352 -tyGDVPKAARDALAADl-----TRLSESLRKL 378 Paracoccus denitrificans
2_pfamImport 282 ---RRFSPEEADTLGAE-AQnraTAITGQISQM 310
Q2S9N7       355 ---PTAEDNEEQIAICEnQA---LQLREQIIIR 381 Hahella chejuensis KCTC 2396
Q21NX0       314 ---LPVIPSDARTQLVSaLD---LALSASASSQ 340 Saccharophagus degradans 2-40
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