4ECG


Conserved Protein Domain Family
Peptidase_M75
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pfam09375: Peptidase_M75 (This model is not part of the current CDD release)
Imelysin
The imelysin peptidase was first identified in Pseudomonas aeruginosa. The active site residues have not been identified. However, His201 and Glu204 are completely conserved in the family and occur in an HXXE motif that is also found in family M14.
Links
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Statistics
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PSSM-Id: 518866
Aligned: 45 rows
Threshold Bit Score: 96.7487
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4ECG_A         44 ALPTY-----KDXLTK-XTAYKNAVDKFI--ASGSK---------------NDLADACDAWRAVRVPWEQSEAFLF-GVA 99  Parabacteroide...
WP_011719027  150 AAARY-----HQFVVGqVQALVTGTATFC--AAVKA---------------GDLAAARRAYPAARWHYEAIEPVAE---- 203 Acidothermus c...
Q82AX9        138 AVAAY-----REYAQEqADETLPKAEAFA--KAVKA---------------GDIEAAKKEFATSRLGWERTEPVAE---- 191 Streptomyces a...
jgi:Arth_0230 168 GTAQY-----VAYVKDqTEQLLAGTKKFA--EAYAS---------------GDAATAKNLYAATRMHWERIEPVAE---- 221
Q6ADY0        152 AVTNY-----TGYVKDqAGQLLSATQTFA--AAYEA---------------GDDTAARAQYPAARQHYERIEPTAE---- 205 Leifsonia xyli...
4_pfamImport    1 ALAEY-----QIYLTTeVAEFQKSVSALS--TAIAS---------------GNLEAAQTAYGPAREAYARIAPVSE---- 54 
WP_011748029  146 PLSEY-----RVYLVMqGNAAVKAAEALR--DAITA---------------NDLEAAREAWHQARLPYRRIEPLAY---- 199 Paracoccus den...
WP_012256531   39 GIKDYllgqtRALVTA-TADLQTASNRYYdlAQATNfdyaslwqnqqreviAALNAAREAWITASPIYEKMEGIVAg--- 114 Chloroflexus a...
Q2S9N7         67 ATERH-----DAALHA-IEKLNRGLQQFI--SAPTP---------------ESLSEAREDWLQAHTALQELKVWGQ-LPA 122 Hahella chejue...
Q21NX0         56 GSQIL-----NQSLSA-TQALNSAITTLL--NTPSE---------------DALLQAQKAWATAAITYQEFNVFAQlQPQ 112 Saccharophagus...

4ECG_A        100 dlaqL--------DPSLDSWPL-DKNGIEEIIAtGef--------------sKISgaVDEDAEDg--------P------ 142 Parabacteroide...
WP_011719027  204 -----------------------SFGDLDPAID-Ar------------------LddVADP------------------- 222 Acidothermus c...
Q82AX9        192 -----------------------SFGDIDPKVD-Vr------------------EdgLEDGQDP---------------- 213 Streptomyces a...
jgi:Arth_0230 222 -----------------------SFGDLDPKLD-Ar------------------EadLAEG------------------- 240
Q6ADY0        206 -----------------------QFGDIDPALD-Lr------------------EadLEQG------------------- 224 Leifsonia xyli...
4_pfamImport   55 -----------------------AFSDLDTAIN-Ar------------------AdyFEKR-EQ---------------- 75 
WP_011748029  200 -----------------------RFSDLEERID-Ar------------------AayLAGR-EQ---------------- 220 Paracoccus den...
WP_012256531  115 -------------TPALAQF----DVDLDAGAA-Gs---------------eDPEnaVSFDLVLpdgrtlpkpG------ 155 Chloroflexus a...
Q2S9N7        123 aks--------ylNHKMSGAPYtRASLLDAAPL-LggyldevpgypksgltyAEDleLDNATLSe--------Qhqfade 185 Hahella chejue...
Q21NX0        113 n--sVlfntvadnHYRIAAHPI-QPGYLDSFGD-Yqysg----------ivhDISmpLNKATLLn--------Qhgmtdl 170 Saccharophagus...

4ECG_A        143 QN-LRGFHTAEKXLFLDG------------------EPRDLETSPFak--------neLEYLK-LVSERXLSDTQDLYNG 194 Parabacteroide...
WP_011719027  223 -AeWTGFHRLEKALWQDD------------------S---------------------LAGMT-AVADRLQSDVRTLADL 261 Acidothermus c...
Q82AX9        214 ATdWTGWHRLEKSLWQDK------------------K---------------------IGDREkKLADQLVTDLTDWQKR 254 Streptomyces a...
jgi:Arth_0230 241 -EeWTGWHRAEKDLFPPAgfq-------------plA---------------------AAERE-KLAAQLVADTEELAQR 284
Q6ADY0        225 -QsWTGWHRIEKDLWAPAghv-------------psN---------------------AADRK-RLGDRLVSDTQRLYDL 268 Leifsonia xyli...
4_pfamImport   76 DPaFGGLHRIEYGLFEQK------------------S---------------------VDGLA-PVAGKLEQDATALKER 115
WP_011748029  221 DPaFIGYHRIEYGLFAEN------------------R---------------------TEGLA-PFADALVADLTELAAR 260 Paracoccus den...
WP_012256531  156 ----NLFGVTESTLWGTDpafaapvsadwngdgtieFGETLPDANV------------LKASA-DLLAQMANDLDSTAQN 218 Chloroflexus a...
Q2S9N7        186 YYlVYGMHPIEFMLWSHN-------------------DPAQQSTRFivnaappdterrRELLR-LQGERLLQDMTELAAA 245 Hahella chejue...
Q21NX0        171 ADaALGFYAIEYMLFGYQ--------------------NTRTIKDY------------IAHLE-LTSAHQTHGYQNLEET 217 Saccharophagus...

4ECG_A        195 WLkglgt-sdvpSSYAEAXkkhdgsaysIGnvyqAIE--LXLngnNGXAGISNEVGSAKIT--DPVtawngsnkdatdpN 269 Parabacteroide...
WP_011719027  262 VAtq----------------------------tyQPA--QIA---NGAVELLDEIARSKVT------------------- 289 Acidothermus c...
Q82AX9        255 VGka----------------------------eiTPS--SMA---NGAKELLDEVATGKVT------------------- 282 Streptomyces a...
jgi:Arth_0230 285 TRtv----------------------------elTAD--KLG---NGAKELLDEVATGKVT------------------- 312
Q6ADY0        269 VYak----------------------------gfSLTldQIS---NGASSLMEEVAGSKIT------------------- 298 Leifsonia xyli...
4_pfamImport  116 IRgl----------------------------riSPD--RMM---AGTASALNRFASTASD------------------- 143
WP_011748029  261 LKqa----------------------------plDPGllIEI---PGESAL--QIAQGQIP------------------- 288 Paracoccus den...
WP_012256531  219 WTp----------TESDAF---------T-----ALV--VMV---PTMSEYFASWRDSRF-------------------V 250 Chloroflexus a...
Q2S9N7        246 WRppsgsiflkgKSMSQME---------------AVR--EAN---PWLIALIDFIDREVVGalKPKd------------G 293 Hahella chejue...
Q21NX0        218 PN----------NRRRLLL---------QL----QND--ILL---EDMRYQADYWQSPALS------------------- 250 Saccharophagus...

4ECG_A        270 NPGVLAVESWYSWNSLDDYKN-NIVSIKNAYfggRDldeesasesSLHALTKXI-NP--T----LDSLXVVQIDKTIDAI 341 Parabacteroide...
WP_011719027  290 -----GEEERYSHTDLYDIDA-NLAGSKAAF----Q---------AVEPILRER-DP--A----LATTIDARFADVEAAL 343 Acidothermus c...
Q82AX9        283 -----GEEDRYSHTDLSDFKG-NVEGAQKAY----E---------LLKPVAKEN-DA--A----LATELDKQFTALNTLL 336 Streptomyces a...
jgi:Arth_0230 313 -----GEEEIWSHTDLWDFQA-NVDGARIAF----E---------NLKPVLAQK-DP--E----LSKSLDTKFAALQAEL 366
Q6ADY0        299 -----GEEETFSHSDLWDFAA-NVEGAQVAY----E---------TVRDVLVEKgDAgkA----MAKKLDAEFAAIGKLL 355 Leifsonia xyli...
4_pfamImport  144 -----AGEDRYAHTDLQALSG-LLEGSGKTA----D---------VLRPIVMKA-DP--K----AFEGIDKDAASIRKLL 197
WP_011748029  289 -----QGENLYAGNDLQDLAA-SLEGIGKLA----G---------LLRQVVAGV-DP--A----LDKVIEQDMQAAEAHL 342 Paracoccus den...
WP_012256531  251 LGDASTQRDFNVISRLADIQD-ILSGLEVVY----A---------QVRPRVEAV-DP--A----QAEQIATGLRDLRAFV 309 Chloroflexus a...
Q2S9N7        294 EPGWRFQEHLEFSQDAAHFWRgRMKAMQPFL--------------------TEP-AL--F----TDAQTRNSLKELRLKL 346 Hahella chejue...
Q21NX0        251 -------NEWLTLSPKQHYSV-VVHAFKQSA---SS---------LLLEVIEAA-KS--SqqaaGASPDRVTRDRVKMSL 307 Saccharophagus...

4ECG_A        342 NAI-GY-PFR------NNLGDTEHINTATE-AC---ADLTTGLGVV 375 Parabacteroides distasonis ATCC 8503
WP_011719027  344 RPL-AR-GTGwv--syEAVDAATRRNLAQRi-----DALAEPLSRV 380 Acidothermus cellulolyticus
Q82AX9        337 DKY-RTdKTSydftsyDKVGKADRKELSDAv-----NALAEPLSKL 376 Streptomyces avermitilis
jgi:Arth_0230 367 KTH-AK-GDGfa--yyNELSPEQVQRLAALv-----DSLGEPLSNL 403
Q6ADY0        356 SRY-AS-GEGya--syTQLSTAQVKELSDKv-----NALSEPLSQL 392 Leifsonia xyli subsp. xyli
4_pfamImport  198 GTS-AE-GNGyk--ayDALSSDEKTKIKEGa-----AQLAAQFTKL 234
WP_011748029  343 AAIa---AEAhp--tyGDVPKAARDALAADl-----TRLSESLRKL 378 Paracoccus denitrificans
WP_012256531  310 ADIyTQeRNG------RRFSPEEADTLGAE-AQnraTAITGQISQM 348 Chloroflexus aurantiacus
Q2S9N7        347 EGC-LT-ALS------PTAEDNEEQIAICEnQA---LQLREQIIIR 381 Hahella chejuensis KCTC 2396
Q21NX0        308 SSLkHA----------LPVIPSDARTQLVSaLD---LALSASASSQ 340 Saccharophagus degradans 2-40
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