Conserved Protein Domain Family
HNF_C

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pfam09354: HNF_C 
HNF3 C-terminal domain
This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterized by the FxIxxIL sequence.
Statistics
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PSSM-Id: 401339
View PSSM: pfam09354
Aligned: 11 rows
Threshold Bit Score: 53.3991
Threshold Setting Gi: 637243800
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAB16313     444 HPFSISSLMnVTDhqQQ---------Hyqq----hphHQTytpakDLRAYQDAVQ-YynNGMNSltglmpppvndsvpaq 509 Pacific transpa...
XP_006003523 343 HPFSITHLM-SSE--QQ---------Y----------QKM-----DLRSYEQMAH-Y--PNYGS---------------- 376 coelacanth
XP_008101045 409 HPFSINNLMsSSEqqQQ--------------------QKL-----DFKAYEQALQ-YssSSYGA---------------- 446 green anole
XP_005989222 364 HPFSINNLMsSSE--QQ---------Q----------HKL-----DFKAYEQALQ-Y--SSYGP---------------- 398 coelacanth
Q8AWH1       354 HPFSINNLMsSSE--QQ--------------------HKL-----DFKAYEQALQqY--SSYSG---------------- 388 tropical clawed...
EEN69167     370 HPFSINSII-SQD------------------------HKLt----ELKGYDPMQY----SGYASmyn------------- 403 Florida lancelet
XP_006009988 356 HPFSINNLM-SSE--QQ---------H----------HKM-----DLKAYEQVMH-Y--SGYGS---------------- 389 coelacanth
CAG09884     325 HPFSINNLM-SSE--QQ---------Hh---------HKM-----DLKTYEQVMH-Y--SGYGS---------------- 359 spotted green p...
XP_006626196 339 HPFSINNLM-SSE--QQ---------H----------HKM-----DLKTYEQVMH-Y--SGYGS---------------- 372 spotted gar
XP_005422710  97 HPFSINNLMsSSE--QQ---------HhhphhqhhhpHKM-----DLKAYEQVMH-Y--SGYAS---------------- 141 medium ground-f...
EHB18836     210 HPFSINNLM-SSE--QQhhhshhhhqP----------HKM-----DLKAYEQVMH-Y--PGYGS---------------- 252 naked mole-rat
BAB16313     510 cTIASsGSpvnsassSSVSTPSPSSSS----STSHY 541 Pacific transparent sea squirt
XP_006003523 377 -AVAN-DL-------SPLANKNGLEMPaiscEGNYY 403 coelacanth
XP_008101045 447 -G----GLplggggaSSVGGRGGIEPSa--lEPSYY 475 green anole
XP_005989222 399 -NLSA-SLpl---gsASMGGRSNIEPSa--lEPSYY 427 coelacanth
Q8AWH1       389 -GLP--GMpl---gsPSMAGRGSIEPSa--lEPTYY 416 tropical clawed frog
EEN69167     404 ------------tnpSVVPKQEMETPAstepATGYF 427 Florida lancelet
XP_006009988 390 -PMPG-GLs-----mSSVATKTGLE-SpisnDTSYY 417 coelacanth
CAG09884     360 -PMAG-ALs-----mGSMAGKHGLDSAsi-pDTAYY 387 spotted green pufferfish
XP_006626196 373 -PMTG-ALs-----mGSMTSKGGLETSpistDTSYY 401 spotted gar
XP_005422710 142 -PVPA-GLa-----mAPVTNKSALEASplagETSYY 170 medium ground-finch
EHB18836     253 -PMPG-SLa-----mGPVTNKAGLDASplaaDTSYY 281 naked mole-rat
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