Conserved Protein Domain Family
HNF_C

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pfam09354: HNF_C (This model is not part of the current CDD release)
HNF3 C-terminal domain
This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterised by the FxIxxIL sequence.
Statistics
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PSSM-Id: 518850
Aligned: 10 rows
Threshold Bit Score: 54.4958
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006009988 355 NHPFSINNLM-SSE--QQ---------H-----------HKM-----DLKAYEQVMH-Y--SGYGS-------------- 389
XP_006626196 338 NHPFSINNLM-SSE--QQ---------H-----------HKM-----DLKTYEQVMH-Y--SGYGS-------------- 372
XP_008101045 408 NHPFSINNLMsSSEqqQQ---------------------QKL-----DFKAYEQALQ-YssSSYGA-------------- 446
XP_005989222 363 NHPFSINNLMsSSE--QQ---------Q-----------HKL-----DFKAYEQALQ-Y--SSYGP-------------- 398
Q8AWH1       353 NHPFSINNLMsSSE--QQ---------------------HKL-----DFKAYEQALQqY--SSYSG-------------- 388 tropical clawed...
XP_006003523 342 SHPFSITHLM-SSE--QQ---------Y-----------QKM-----DLRSYEQMAH-Y--PNYGS-------------- 376 coelacanth
XP_011614260 339 NHPFSINNLM-SSE--QQ---------Hh----------HKM-----DLKTYEQVMH-Y--SGYGS-------------- 374 torafugu
XP_023439994 371 NHPFSINNLM-SSE--QQhhhshhhhqP-----------HKM-----DLKAYEQVMH-Y--PGYGS-------------- 414 nine-banded arm...
NP_990101    351 NHPFSINNLMsSSE--QQ---------HhhhphhhhhpsHKM-----DLKAYEQVMH-Y--SGYAS-------------- 397 chicken
NP_001071991 449 PHPFSISSLMnVSDpqQQ---------Hyqq-----hphHQSytqakDLRAYQDAVQ-YynNGMNSltglmpppsvndti 513 vase tunicate
XP_006009988 390 ---PMPG-GLSM-----SSVATKTGLE-SpisnDTSYYQ 418
XP_006626196 373 ---PMTG-ALSM-----GSMTSKGGLEtSpistDTSYYQ 402
XP_008101045 447 ---G----GLPLggggaSSVGGRGGIEpSa--lEPSYYQ 476
XP_005989222 399 ---NLSA-SLPLg---sASMGGRSNIEpSa--lEPSYYQ 428
Q8AWH1       389 ---GLP--GMPLg---sPSMAGRGSIEpSa--lEPTYYQ 417 tropical clawed frog
XP_006003523 377 ---AVAN-DL-------SPLANKNGLEmPaiscEGNYYT 404 coelacanth
XP_011614260 375 ---PMAG-ALSM-----GAMAGKHGLDsAsi-pDAAYYQ 403 torafugu
XP_023439994 415 ---PMPG-SLAM-----GPVTNKAGLDaSplaaDTSYYQ 444 nine-banded armadillo
NP_990101    398 ---PVPA-SLAM-----GPVTNKNPLEsSplagETSYYQ 427 chicken
NP_001071991 514 pqcSIAPsGspvnsassssvstpspsssssashyssalh 552 vase tunicate
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