Conserved Protein Domain Family
HNF_C

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pfam09354: HNF_C (This model is not part of the current CDD release)
HNF3 C-terminal domain
This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterized by the FxIxxIL sequence.
Statistics
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PSSM-Id: 490308
Aligned: 10 rows
Threshold Bit Score: 56.4095
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006009988 355 NHPFSINNLM-SSE--QQH----------HKM-----DLKAYEQVMH-Y--SGYGS-----------------PMPG-GL 395
2_pfamImport   1 PHPFSISSLMnVTDhqQQHyqq----hphHQTytpakDLRAYQDAVQ-YynNGMNSltglmpppvndsvpaqcTIASsGS 75 
XP_004175168 358 NHPFSINNLMsSSE--QQHhhphhqhhhpHKM-----DLKAYEQVMH-Y--SGYAS-----------------PVPA-GL 409
1_pfamImport   1 NHPFSINNLM-SSE--QQP----------HKM-----DLKAYEQVMH-Y--PGYGS-----------------PMPG-SL 41 
4_pfamImport   1 NHPFSINNLM-SSE--QQHh---------HKM-----DLKTYEQVMH-Y--SGYGS-----------------PMAG-AL 42 
XP_006626196 338 NHPFSINNLM-SSE--QQH----------HKM-----DLKTYEQVMH-Y--SGYGS-----------------PMTG-AL 378
XP_008101045 408 NHPFSINNLMsSSEqqQQ-----------QKL-----DFKAYEQALQ-YssSSYGA-----------------G----GL 449
XP_005989222 363 NHPFSINNLMsSSE--QQQ----------HKL-----DFKAYEQALQ-Y--SSYGP-----------------NLSA-SL 404
Q8AWH1       353 NHPFSINNLMsSSE--QQ-----------HKL-----DFKAYEQALQqY--SSYSG-----------------GLP--GM 393 tropical clawed...
3_pfamImport   1 SHPFSITHLM-SSE--QQY----------QKM-----DLRSYEQMAH-Y--PNYGS-----------------AVAN-DL 41 
XP_006009988 396 SM-----SSVATKTGLE-SpisnDTSYYQ 418
2_pfamImport  76 PVnsassSSVSTPSPSSsS----STSHYS 100
XP_004175168 410 AM-----APVTNKSALEaSplagETSYYQ 433
1_pfamImport  42 AM-----GPVTNKAGLDaSplaaDTSYYQ 65 
4_pfamImport  43 SM-----GSMAGKHGLDsAsi-pDTAYYQ 65 
XP_006626196 379 SM-----GSMTSKGGLEtSpistDTSYYQ 402
XP_008101045 450 PLggggaSSVGGRGGIEpSa--lEPSYYQ 476
XP_005989222 405 PLg---sASMGGRSNIEpSa--lEPSYYQ 428
Q8AWH1       394 PLg---sPSMAGRGSIEpSa--lEPTYYQ 417 tropical clawed frog
3_pfamImport  42 -------SPLANKNGLEmPaiscEGNYYT 63 
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