Conserved Protein Domain Family
NuA4

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pfam09340: NuA4 
Histone acetyltransferase subunit NuA4
The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. NuA4 complexes are highly conserved in eukaryotes and play primary roles in transcription, cellular response to DNA damage, and cell cycle control.
Statistics
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PSSM-Id: 401327
View PSSM: pfam09340
Aligned: 128 rows
Threshold Bit Score: 55.2117
Threshold Setting Gi: 196017960
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002118693  18 KLKEIQANKEELTRNLQDIEYQIYCRERKLFQTS-RKFGNVAT-GLkvQAIFNdssqhesdkssmcstdccKYGRQRAER 95  Trichoplax adha...
XP_005849179  10 ALEAFAARREVIAGDIAKLEKQIYELESDYFTADyTNFGNV---GF--GEFLT-------------------SKSAQAKN 65  Chlorella varia...
Q4DPF3        40 QLQQLQKRREALESHLETLDLRVYDLETAYLRQY-VELGGCLFdGFglERQQQwggvt---------aaaaAGSQAAAYR 109 Trypanosoma cruzi
XP_001419739  10 HLKQR---RAKIEADAAEIERQVYDLETSLLTDH-SSGGNVLR-GF--ELALA------------------QSKQQAQKR 64  Ostreococcus lu...
XP_009403912  15 MLAALVSKRDKLQDELRVIERQVYDLETTYLQDS-NQNGSVLK-GF--EGFLS------------------SSKGTSNMK 72  wild Malaysian ...
XP_004247732  14 VLASLLNKREKLQEELRNVEKQVYELETSYLQES-GTFGNALK-GF--EGFLS------------------TSNKNSNLK 71  tomato
ANM66595      14 MLTSLLNKREKLRQELRSIEKQVYELETSYLQES-SHIGNALK-GF--EGFLS------------------SSKSTASAK 71  thale cress
CBI23643      16 MLASLVSKRERLQDELRVIEKQVYEMETNYLQDS-SHFGNVLK-GF--EGFLS------------------SSKNTTNLK 73  wine grape
XP_010652367  15 MLASLISKRAKLHEELQNIEKQLYTMETGYLQDP-SQCGNVLK-GF--EGFLS------------------SSKSSTLLK 72  wine grape
XP_001783399  13 TLSLLNQRKEQLQEELRTVEKQLYDLETTYLHDS-SQCGNVLK-GF--EGFLS------------------SMKGSGNLK 70  Physcomitrella ...
XP_002118693  96 shsSLDagddcmnlsrnspgqegAMKDEFIFSLSSMTSP 134 Trichoplax adhaerens
XP_005849179  66 k--NRQ-----------------FRLEDRVFSLSSITSP 85  Chlorella variabilis
Q4DPF3       110 arl------------------hsFSPSDRVFTASSVGAL 130 Trypanosoma cruzi
XP_001419739  65 ---VKP-----------------FKTEERTFSVSSASSQ 83  Ostreococcus lucimarinus CCE9901
XP_009403912  73 r--SRK-----------------FQPEDRLFSLSSITSP 92  wild Malaysian banana
XP_004247732  72 r--SRK-----------------FQLEDRLFSLSSVTSP 91  tomato
ANM66595      72 r--SRK-----------------FQPEDRVFSLSSVTSP 91  thale cress
CBI23643      74 r--SRK-----------------FQLEDRLFSLSSVTSP 93  wine grape
XP_010652367  73 r--SRK-----------------FQPEDRLFSLSSITSP 92  wine grape
XP_001783399  71 r--PRK-----------------FQPEDRLFSLSSVTSP 90  Physcomitrella patens
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