Conserved Protein Domain Family
VTT_dom
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pfam09335: VTT_dom 
VTT domain
This is the VTT (VMP1, TMEM41, and TVP38) domain found in sequences from all cellular organisms, including Golgi apparatus membrane protein TVP38 from Saccharomyces cerevisiae, which is involved in vesicular trafficking and spindle migration. This domain was previously called SNARE-associated domain but was renamed as there is no evidence that it associates with SNARE proteins.
Links
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Statistics
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PSSM-Id: 490291
Aligned: 47 rows
Threshold Bit Score: 57.3206
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011386954 517 IPg---SLIMN--VVFGAMY-GTYS-----GTLYTSVLTSVGGVFCYLLSAPLAplitslpglakplDAMRR-ALSPGRA 584
WP_015924272  39 SDviivFEGYL--TTLGGQF-HFIP-----VMINSILGSLIGSILVYWFGYKKGnev--------lrYKIVLkYIDEKHI 102 Ruminiclostridi...
1_pfamImport   1 IP----DEMIV--MSGGFVS-SLGIlsiitAFLLTYLGVVSGLSLGYILGKIFG-------------TKVLHkLMKKKKA 60 
Q7NRI9        32 IP----EDITL--VAGGVIS-GLGYanvhyMFVVGMAGVLVGDGIMFLAGRIFGhkv--------lrFKPIArILTQERF 96  Chromobacterium...
WP_012259510  65 VP----YYPLL--IRLGQAF-NPYG-----VAIAAAAGSVLGELVAFYAG-----------------RSGRKaMERTSFY 115 Chloroflexus
Q8F6X3        81 IP----PDVFLmfAVAGKL--NSVL-----VIVSASIGSLIGGSVSYLTGRILLp------------KMERIsTFVKRHE 137 Leptospira inte...
Q8TK61        26 TVlpfgSEALV--IALVYQGfSPFA-----VVMVATTGNFLGSCTTYYLGLKG--------------RNVLDrYLSPSP- 83  Methanosarcina ...
Q9CH44        71 IP----GGITM--AAGVMIF-GPVW-----GFVYNYFGIVAGSFLLFHFGKKYG-------------SSLAKtFVKEKTY 125 Lactococcus lac...
WP_012064371  18 TP-----EMVT--ITGGSLAlGPFK-----GFIIGYLGILSGIITMYFMGRYAQ-------------QIIVKrVGKEELF 72  Alkaliphilus me...
WP_012048245  84 IP----GEVMQ--IAGGYIY-GTLL-----GSVYSLIGITLGSVFVFLLAHIYG-------------RPLVHkIISKKDL 138 Clostridium bot...

XP_011386954 585 RA---SGRSVvisnmnggsngnvwTYLLVLRVLPiVPYGLMNIACGV-LGVPLAPYAGTLAVGSIPWNFVTCQVGDL 657
WP_015924272 103 KR---SEKVFhky---------gkYGLILSKFIPgT-STIMVLFSGV-FRVEKKVCFSYVMISIILQQLVYLLIGRL 165 Ruminiclostridium ...
1_pfamImport  61 KYllkSQQMVeky---------ghYALVTSYFIPvV-RHIVPYLVGM-NNMSFRIYALYSYTTGFVWTLIYFVLGSL 126
Q7NRI9        97 EA---VQEKFeky---------gnWVLFVARFLPgL-RSPIFITAGMtRRVSYWRFLIMDGFAALISVPVWVYLGYY 160 Chromobacterium vi...
WP_012259510 116 DW---VHRQMqhpw-------rapLVLFVLSAPPnPFFDVAGIIAGA-VGVPVWTFVITVFLARIVRMGLVVVLGYT 181 Chloroflexus
Q8F6X3       138 QK---LEHYLhry---------gfWAVVLAALTP-LPYSWVSLAAGA-MKMKYSLFFKGCLF-RIPRFIVFYYLIQF 199 Leptospira interro...
Q8TK61        84 EKlekSERLFnky---------gvY-TLLFTWVPgI-GDVITMVAGL-MQLSFRSFSILVFLGKFGRYLVLAYSVVL 148 Methanosarcina ace...
Q9CH44       126 NK---YMAWLdkgq------krfnIVFALLILSPiAPDDALVLIASQ-TKMSWKFFTWSILLCKPLPILLYSYLLIF 192 Lactococcus lactis...
WP_012064371  73 DK---YTRLVekn---------geVIIGLLFILPvLPDNIICAGAGA-SKVSFKRFVFIAAVAKLITTFVYAYSMEL 136 Alkaliphilus metal...
WP_012048245 139 KF---FDRMLnig--------gikLIVFLLYLIPgIPKDALGYICGI-SDIKFKDFFILSTLGRIPGVLASAYFGAN 203 Clostridium botulinum
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