pfam09324: Sec7-like_HDS (This model is not part of the current CDD release)
Mon2/Sec7/BIG1-like, HDS
This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins. Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis. Sec7 has four HDS1-4 domains, which act to integrate the signals from several small GTPases, including Arf1 itself, to switch Sec7 from a strongly autoinhibited to a strongly auto activated form.
Jiyao W et al.(2023). "The conserved domain database in 2023.",