Conserved Protein Domain Family
XLF

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pfam09302: XLF (This model is not part of the current CDD release)
XLF N-terminal domain
XLF (also called Cernunnos) is Xrcc4-like-factor, and interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining. It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated down-regulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining. This family contains Nej1 (non-homologous end-joining factor), and Lif1, ligase-interacting factor. XLF forms one of the components of the NHEJ machinery for DNA non-homologous end-joining. This entry represents the N-terminal beta sandwich domain of XLF.
Statistics
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PSSM-Id: 518812
Aligned: 171 rows
Threshold Bit Score: 46.6527
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OAQ24110       16 EWRLlfvpgsgtslassaaasqgSASQPHsqtgnivpeeyasdtfLV-KAFFseTEKYYVVILTNLKQTWYEKLEHYAIR 94 
RZF46698        2 MWKQfi----------------lNKKL------------------YLlRNSN--DNGRFQIFITDLLSLWTEDLSEEELL 45 
EFN84387       10 VWRSl------------------EIDDKA----------------YVvCFTK--ENESWKVILTDLIEIWTENLTYKIIL 53 
XP_026299483    1 MWNSi------------------KINNDT----------------YMiSIIY--KNDTIKIFLTNLIEIWIETLTKEIIL 44 
KAF7267752      1 MWKTf------------------THLSNP----------------YLfRCEI--EEDSFDLYLTNLENIWKCSSTDMELM 44 
22_pfamImport   1 MWNLi------------------SSEPET----------------YLlRLRE--NDGEYDFFLTDFKRVWKVKLNEVDMV 44 
1_pfamImport    1 GWLKv------------------GSDG------------------YAaRFES--DEENYVIYLTDMASLWCQQQTAAEIM 42 
KAF0310333      8 PWRA-------------------WEGLDE----------------VLyQFSA--GDGGYSLLLTDLCQLWTETVDADTFV 50 
VDP09458      131 DWQPvty--------------lhTGGY------------------WFaKLDV--EHEVVKVMFTDLKQLWLETVELDAFC 176
CAD5115366     15 PWVGik----------------tQSGNS-----------------IIvKYIF--SHKSYELLLSDGISCYYERMEAEELS 59 
OAQ24110       95 ERSK-LIRSFAYEEdTQLEALLLslstvistahdvpvsgskTSATPSKQILQgrhg--klyMIVGFEF-Gla----tMYW 166
RZF46698       46 QRCKdMNPLHE----ASSEILIQrinel---------velnSSEVKT-TLTEnkne--qleLGVSSYL-Kgv----iFKI 104
EFN84387       54 CKFEtSNRLVDFSKvSNWKQLVMdml------------ndiPKHVVETSISQ---------IKLQKDW-Hfg----kLKF 107
XP_026299483   45 DRCRkLNPLLNVEA-IDYNDIILnil------------tnmSEYIVEASIEH---------IKLRAQF-Ngg----sIKF 97 
KAF7267752     45 ESFKeNNPLIEATSdVIKSDLLSii--------------naFDNESISIVNEgn-----enCKLSLTR-KstniaddIVY 104
22_pfamImport  45 ESIQeLNPRIE----ASHRALLDktv------------tllFKNEDISCIKGees----vtVKIESKI-Ggf----pFIF 99 
1_pfamImport   43 KRCQdLNPLIE----STSKGLIRqlr------------amlANNPESHNLHVdsnn-qtaiLKIESRLeSni----pFIW 101
KAF0310333     51 ERLReLNPALEATGgQALPRLVAavg-------------aaDSGAAWdg----------ptLRLDSRR-Dgv----pLRW 102
VDP09458      177 ERLKeSNSNLE----GDAEPLVQlck------------smlQQKTDC-AVDVetfedssliAKFHGKF-Adv----pFRW 234
CAD5115366     60 ERNKeTNPSLE----LTQGKLLHliks----------aftgERNVKM-IVKKesd---kiqCSFTYSI-Sgt----lFQW 116
OAQ24110      167 KFKLSP 172
RZF46698      105 KFLLSL 110
EFN84387      108 SLDLVK 113
XP_026299483   98 SVNLEK 103
KAF7267752    105 SFFLKP 110
22_pfamImport 100 NLKLDL 105
1_pfamImport  102 QFDLSL 107
KAF0310333    103 QFRLRP 108
VDP09458      235 STHVAV 240
CAD5115366    117 KIIARR 122
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