4J2X


Conserved Protein Domain Family
LAG1-DNAbind
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pfam09271: LAG1-DNAbind (This model is not part of the current CDD release)
LAG1, DNA binding
Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.
Links
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Statistics
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PSSM-Id: 518792
Aligned: 45 rows
Threshold Bit Score: 101.62
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4J2X_A         27 VLILHAKVAQKSYGNEKRFFCPPPCVYLMGSgw----------------------------------------------- 59   house mouse
EPB85710      331 VIIMTSKVAQKSYGTEKRFLCPPPTAILVGSswwtppslasqq----------------------------seehrqdal 382 
Q5KPQ7        116 LEVWHPTTGQKSYGKERRMLNPPPILRLSGP------------------------------------------------- 146  Cryptococcus ...
XP_006956985  177 ISISTPQTAQKSYGNEKRFIAPPPQVCLIGKnwnsenkkggqshalaldlgqlspsvqvklgnglqahdcelkwsqftes 256 
XP_007873369  401 IIIYTSKVAQKSYGTEKRYLCPPPCLRLLGSk------------------------------------------------ 432 
O74412        473 FYLCMPSLCQKSYGTERRYLCPPIVLYLLGTtwlnnvtdn----------------------------------lkisaq 518  Schizosacchar...
XP_002174628  395 MKVFMPSLGQKSYGKERRYICPPAVVYLLGSswfrcpldk----------------------------------iniian 440 
XP_011392222  379 IRCSHASVAQKSYGSEKRFFNPPPIISITGP------------------------------------------------- 409 
GAC72297      358 VRCAHASVAQKSYGSEKRFFNPPPIISVTGP------------------------------------------------- 388 
XP_012192489  369 IRCSHASVAQKSYGSEKRFFNPPPIISVTGP------------------------------------------------- 399 

4J2X_A         60 -kKKKE---------QMETDGcSEQESQPCafigig--nsdqemQQLNLE-----------------------------G 98   house mouse
EPB85710      383 fcDKDNvirappsltICISGEtSGQQSGRIewyalsgtmsnan------------------------ddwyrnsrketlA 438 
Q5KPQ7        147 -------------------------ASSCIssitmvsvvspnitQPVAI------------------------------- 170  Cryptococcus ...
XP_006956985  257 qsKQSNlpltppdssPNSNKSdYVEESNDTnqmt---------------------------------------------- 290 
XP_007873369  433 ----wFegcladiplNSFPGTnQKENTYGTnvfgmys-fmdiyaTSLLLDveesfnissmdcycsdgtifkpgsskttpV 507 
O74412        519 tlEDKDnpkfaknifYYNADGaLISPETDIakstyqltnynentNFDSFP-----------------------------V 569  Schizosacchar...
XP_002174628  441 aaDDPDnlktsetptFYTSSSdSATNLLSLgqvklddpleqqqsPSP--------------------------------I 488 
XP_011392222  410 --LRRYaehgaatllTPLSSEdP-EEDQCRvslvvrgdtdeyfsNENVAV-----------------------------L 457 
GAC72297      389 --LRRYaehgaatltTSSTSEdADEEEQCRvsllvrgdtdeffsNENVAV-----------------------------L 437 
XP_012192489  400 --LRRYaehgaavlhTSQTAEdADEEDQCRvsllvrgdtdefysNENVAV-----------------------------L 448 

4J2X_A         99 KNY--CTAKTLY---------------IS-DSD-KRKHFMLSVKMFYGN----------------SDD------------ 131  house mouse
EPB85710      439 GGR--CVLKRLY---------------IN-DADeKRKKVECLIKVQLAN----------------Gl------------- 471 
Q5KPQ7        171 -----CAPQTHHmgrppditphlgtpgVE-DKKkERREEQKKLRTAALN------------------------------- 213  Cryptococcus ...
XP_006956985  291 -mlgkALARHLH---------------IT-DVAdDRKITNCYAEVVIPSllsr--------------------------- 326 
XP_007873369  508 WGK--INLRSMY---------------VP-DRKeKIRSACLKVQLHKKNke----------------------------- 540 
O74412        570 WGN--ALLKTIY---------------YTgQGKnDGFGRSTFLQLSVQS----------------KTK------------ 604  Schizosacchar...
XP_002174628  489 WAN--TVLKTLY---------------YSgKGDhNTYGRSTTLQVHVRT----------------PQK------------ 523 
XP_011392222  458 DGRleTKMRSLY---------------VT-PTG-RSKSFRLQLNLLRPSglephlpifsplkksrAADalspamsigspa 520 
GAC72297      438 DQTleAKMRSLY---------------VT-PTG-RSKAFRLQLNLLRPSglephlpifsplkksrAADplspaisagspa 500 
XP_012192489  449 DSRleTKMRSLY---------------VT-PTG-RSKAFRLQLNLLRPSglephlpifsplkksrASEavspaistespa 511 

4J2X_A        132 -------------------IGVFLSKRIKVISKPSKKKQSLKNAD 157  house mouse
EPB85710      472 ------------------mLGTLSSRGIKVISKPSKKRQSVKNIE 498 
Q5KPQ7        214 -------------------AGFAATLPKNRNATDLKDRTLLKDGL 239  Cryptococcus neoformans
XP_006956985  327 ----------------npfKGSFALPNMNIISKASKQRKPKRNEE 355 
XP_007873369  541 -----------------fnFVQFQSSPICIISKASQKKTSSKNND 568 
O74412        605 -------------------YFKLENLRLGVISKPSQKRALMKVSD 630  Schizosaccharomyces pombe 972h-
XP_002174628  524 -------------------RITMDKLRIGIISKPSQKKMMMKVSD 549 
XP_011392222  521 nepiengsevlsrlpkelaWASFESAPVTIISKSSKKTAKPRGEL 565 
GAC72297      501 ydqadsgsetlsrlpkglaWASFESAPVTIISKSSKKTAKPRGQI 545 
XP_012192489  512 neqtdagsevlsrlpkglaWASFESAPVAIISKSSKKTAKPRGQT 556
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