3KPH


Conserved Protein Domain Family
MA-Mit
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pfam09245: MA-Mit 
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Mycoplasma arthritidis-derived mitogen
Mycoplasma arthritidis-derived mitogen (MA-Mit) adopts a completely alpha-helical structure consisting of ten alpha helices. It is a superantigen that can activate large fractions of T cells bearing particular TCR V-beta elements. Two MA-Mit molecules form an asymmetric dimer and cross-link two MHC antigens to form a dimerized MA-Mit-MHC complex.
Links
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Statistics
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PSSM-Id: 312671
Aligned: 3 rows
Threshold Bit Score: 360.057
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KPH_A             5 SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNK-EETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNM 83 
uab:MARTH_orf036  25 SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNK-EETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNM 103
WP_012498442      25 SMKLRVPNPKRPNLPSLKAVKNEVVTLNELDKIIRLTNEnDKTKEVIAQFRSKLNEFYQHAFNILEEYEGIEKHDDIFKM 104 Mycoplasma ...

3KPH_A            84 MFLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLSYFISQNKNFQELWDKAVKLTKEMKIKLKGQKLDLRDGEV 163
uab:MARTH_orf036 104 MFLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLSYFISQNKNFQELWDKAVKLTKEMKIKLKGQKLDLRDGEV 183
WP_012498442     105 MFLKLKVVLDIQRKEPNNVEQIKRNINILDDIMKSADNELSYFVSQDLKFQALWDKAVLLSKTMKAEFKTSRPSTVDPYG 184 Mycoplasma ...

3KPH_A           164 AINKVRELFGSDKNVKELWWFRSLLVKGVYLIKRYYEGDIELATTSDFAKAVFE 217
uab:MARTH_orf036 184 AINKVRELFGSDKNVKELWWFRSLLVKGVYLIKRYYEGDIELKTTSDFAKAVFE 237
WP_012498442     185 PVNSVEKFFGADEDVKTIKWFKSLLIRAANYLIHYYDAPEVFQPKTDFEKAIFE 238 Mycoplasma arthritidis
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