5UV8,5FUC,3LB6


Conserved Protein Domain Family
IL6Ra-bind

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pfam09240: IL6Ra-bind 
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Interleukin-6 receptor alpha chain, binding
Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.
Statistics
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PSSM-Id: 401252
View PSSM: pfam09240
Aligned: 14 rows
Threshold Bit Score: 92.8574
Threshold Setting Gi: 124344
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UV8_A    90 NLTCWIHDv-----------DFLSCSWAVGPGAPADVQYDLYLNVANRrqQY----ECLHYKTDAqGT--------RIGC 146 human
P21183   128 NLTCTTHTvvsshthlrpyqVSLRCTWLVGKDAPEDTQYFLYYRFGVL--TE----KCQEYSRDAlNR--------NTAC 193 house mouse
P26952   122 DLRCWVHE------------GQLSCQWERGPKATGDVHYRMFWRDVRLgpAHn--rECPHYHSLDvNTagpaphggHEGC 187 house mouse
Q00941   132 NLTCEIRAa-----------RFLSCAWREGPAAPADVRYSLRVLNSTGhdVA----RCMADPGDDvIT--------Q--C 186 house mouse
Q6UAN5   203 DLFCYKKSp----------sSKIRCESKPQQNVTIRPNCYLLLRKSPSesFQp--fQCSFSSRTS-----------RCFC 259 spotted green puffe...
O18796   118 QLSCFRKSp----------lSNVGCEWRPRSPPSPTTKAVLLVRKFQNspVEdfqePCQYSLEAQ-----------RFFC 176 pig
5FUC_D    27 QLSCFRKSp----------lSNVVCEWGPRSTPSLTTKAVLLVRKFQNspAEdfqePCQYSQESQ-----------KFSC 85  human
AAR25681 145 DLECVNYDm-----------INLECTWKRGAKTPDNAQQNLYFWHKPLeyVK----ECPNYIISS-GI--------RSGC 200 spotted green puffe...
Q8VHK6   138 DMKCIYYNw-----------QYLVCSWKPGKTVHSDTNYTMFFWYEGLdhAL----QCADYLQDN-EK--------NVGC 193 Norway rat
3LB6_C   142 DMDCVYYNw-----------QYLLCSWKPGIGVLLDTNYNLFYWYEGLdhAL----QCVDYIKAD-GQ--------NIGC 197 human
5UV8_A   147 RFDDISRLSSGSQ------SSHILVRGRSAAFGIPCTDKFVVFSQI 186 human
P21183   194 WFPRTFINSKGFE------QLAVHINGSSKRAAIKPFDQLFSPLAI 233 house mouse
P26952   188 TLDLDTVLGSTPNspdlvpQVTITVNGSGRAGPVPCMDNTVDLQRA 233 house mouse
Q00941   187 IANDLSLLGS---------EAYLVVTGRSGAGPVRFLDDVVATKAL 223 house mouse
Q6UAN5   260 VLDHNEDEMRLSH------FAVLCV--TSITGNTTSNLINFTPLRI 297 spotted green pufferfish
O18796   177 QLAVPEGD-NSFH------IVTLCV--ANSAGSQSSTPQTFEGYGI 213 pig
5FUC_D    86 QLAVPEGD-SSFY------IVSMCV--ASSVGSKFSKTQTFQGAGI 122 human
AAR25681 201 RFPKSSL--PVFT------DINFCVNGSSSEGPLQPQFISLQIQNH 238 spotted green pufferfish
Q8VHK6   194 KLSNLDS--SDYK------DFFIRVNGSSKLEPIRSSYMVFQLQNI 231 Norway rat
3LB6_C   198 RFPYLEA--SDYK------DFYICVNGSSENKPIRSSYFTFQLQNI 235 human
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