1IAR


Conserved Protein Domain Family
IL4Ra_N
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pfam09238: IL4Ra_N (This model is not part of the current CDD release)
Interleukin-4 receptor alpha chain, N-terminal
Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.
Links
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Statistics
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PSSM-Id: 518772
Aligned: 16 rows
Threshold Bit Score: 129.786
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IAR_B         3 VLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLV-FLLS-----EAHTCIPENNGGAG---CVCHLLM-DDVVSAD 72  human
1_pfamImport   1 VLSEPTCFSDFVTTSTCEWKMAGPVNCSTELLLSYELM-SFQKisdtfESRTCVPENKDGAV---CVCSMIV-DIIYSVD 75 
XP_012664392  28 VLLQPACFSDYVSISTCEWKMASPINCSAELHLSYKLD-FGSS-----EAHTCVPKNSEDTG---CMCNMLT-GDVVGGD 97 
KAI4054173    28 VLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLV-FLLS-----EAHTCIPENNGGAG---CVCHLLM-DDVVSAD 97 
3_pfamImport   1 VLREPTCFSDFLSTSTCEWEMDSPTNCSSELRLSYQLD-YDLSp----ENFTCVPENSEDAM---CMCTLFItEDVTSAD 72 
4_pfamImport   1 VLRAPTCFSDYFSTSVCQWNMDAPTNCSAELRLSYQLN-FMGS-----ENRTCVPENGEGAA---CACSMLM-DDFVEAD 70 
2_pfamImport   1 QIGHLKCYNDYFHEMVCSWKVGLHVNCTSEFTLYFQRLlFPLP-----YN-SCVPVNHNENGrlhCMCKIKI-PQTVVND 73 
6_pfamImport   1 HVQEFACFTDYDKELVCHWKVSAQTNCSKQFLLYYSKE-ASSV-----LN-MCVPENEKDSLr--CTCTIYP-DYFVSGL 70 
Q6WG24        28 VLRLTACFSDYISASTCEWKMDRPTNCSAQLRLSYQLN-DEFS-----DNLTCIPENREDEV---CVCRMLM-DNIVSED 97  horse
XP_006105003  28 VRDGPTCFSDYLSTSTCEWRMGGPTDCSAELRLTYQLD-FPNS-----ENHTCVPVNGESAV---CLCDMLM-DIIVSGD 97 

1IAR_B        73 NYTLDLWAGQQLLWKGSFKPSEHV 96  human
1_pfamImport  76 VYTLELWAGQQLLWKDIFQPCHHV 99 
XP_012664392  98 TYMLDLWAGQQLLWTGSFKPIEHV 121
KAI4054173    98 NYTLDLWAGQQLLWKGSFKPSEHV 121
3_pfamImport  73 SYKLALWAGRRLLWTGLFIPSEHV 96 
4_pfamImport  71 VYQLHLWAGTQLLWSGSFKPSSHV 94 
2_pfamImport  74 NYSIEVHSNGSMLLKHSVIPAKTV 97 
6_pfamImport  71 TYILALQFNGTDVWNFNVTPAL-V 93 
Q6WG24        98 VYELDLWAGNQLLWNSSFKPSRHV 121 horse
XP_006105003  98 TYQLDLWAGKQWLWSGSFRPSEHV 121
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