1IAR


Conserved Protein Domain Family
IL4Ra_N

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pfam09238: IL4Ra_N 
Click on image for an interactive view with Cn3D
Interleukin-4 receptor alpha chain, N-terminal
Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.
Statistics
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PSSM-Id: 401250
View PSSM: pfam09238
Aligned: 20 rows
Threshold Bit Score: 101.26
Threshold Setting Gi: 374413771
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IAR_B          7 PTCVSDYMSISTCEWKMNGPTNCST-----ELRLLYQLV-FLLSea-----hTCIPENNG---GAG---CVCHLLM-DDV 68   human
XP_007658551   33 VQCFSDYETKLTCEWKVNRPANCST-----ELQLHYERN-VRPErn-----sLCVPENKKssgGVSpveCVCTVEV-QKI 100  platypus
XP_027324897   32 FGCFSDFAKELVCDWKVPAQTNCSE-----EYLLYYREE-FLFHq------nVCVPENGK---ESFt--CTCTIYP-DYF 93   mallard
AEZ49865       27 FNCFNDYEAEMTCSFSSESLRNCSGynmnvTQKLAYEINrY-----------SCVFERSHh--NAI---CECKIEV-EGF 89   zebrafish
ELW66410       32 PTCFSDFLSTSTCEWEMDSPTNCSS-----ELRLSYQLD-YDLSpe----nfTCVPENSE---DAM---CMCTLFItEDV 95   Chinese tree ...
XP_008256130   32 PSCISDYLSISTCEWEMARPTNCST-----ELSLSYQLE-AVVPen-----yTCIPENFR---DAV---CVCHMFM-EAM 93   rabbit
XP_003795797   32 PACFSDYVSISTCEWKMASPINCSA-----ELHLSYKLD-FGSSea-----hTCVPKNSE---DTG---CMCNMLT-GDV 93   small-eared g...
XP_012398788   33 VNCSCDYDTLISCEWKMNRLINCSS-----EIWLYYERK-NDNSif-----pRCTPKSKRenkATLsleCVCQSKV-DNF 100  Tasmanian devil
XP_020941533   32 PICLSDYVSTSTCEWRMAGPVNCSA-----EFRLSYQLK-FFNTen----htTCVPENRA---GSV---CVCHMLM-ESI 94   pig
XP_010596776   32 PTCFSDFVTTSTCEWKMAGPVNCST-----ELLLSYELM-SFQKisdtfesrTCVPENKD---GAV---CVCSMIV-DII 98   African savan...
1IAR_B         69 VSADNYTLDLWAGQQLLW-KGSFKPSEHV 96   human
XP_007658551  101 YSSDIFELKIQAGDNVLW-NLTFSPFENV 128  platypus
XP_027324897   94 VSGLTYVLALQFNGTDMW-NYSVTPALVV 121  mallard
AEZ49865       90 ITEEIFSTTLLKGTKVLL-QRDFK----T 113  zebrafish
ELW66410       96 TSADSYKLALWAGRRLLW-TGLFIPSEHV 123  Chinese tree shrew
XP_008256130   94 FGADTYKLDLWAGPQLLW-SAFFKPSENV 121  rabbit
XP_003795797   94 VGGDTYMLDLWAGQQLLW-TGSFKPIEHV 121  small-eared galago
XP_012398788  101 VNADEYLLQIQSDTQVLWeEQNFLPSQNV 129  Tasmanian devil
XP_020941533   95 VIVDTYQLDLWAGEQLLW-NSSFKPSQNV 122  pig
XP_010596776   99 YSVDVYTLELWAGQQLLW-KDIFQPCHHV 126  African savanna elephant
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