1USV,7DME,3N72


Conserved Protein Domain Family
Aha1_N
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pfam09229: Aha1_N (This model is not part of the current CDD release)
Activator of Hsp90 ATPase, N-terminal
Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity.
Links
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Statistics
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PSSM-Id: 518766
Aligned: 206 rows
Threshold Bit Score: 51.3987
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1USV_B         27 DKNCIGWAKEYFKQKLVgveagSVkDKk------yAKIKS-VSSIEGDCEVNQRKGKVISLFDLKITVLIEGHVd----- 94  brewer's yeast
XP_009132083   60 EKNLTKWATDRLKELLGsvgslQFsSGk-------AEIFD-VNRCVGDAFLVSVRNKKRVGYTYELSLKVQGEWsv---- 127
XP_002453280   68 EKNLNSWANGRIKDLLGslgslDFpTGk-------ASIDE-VSKCSGDAFQVTVRNKKRVGYNYELSLRFKGEWli---- 135
XP_002976673   67 ERNLNDWAISKLRELLLaaepiTFgEGs-------AYVTD-VSRCTGDAAILTVRGKRRVDYSFDILLDFLGKIe----- 133
XP_002979005   59 EKNLNSWAIARLKEMLLalepiEYaDGs-------ARVTE-VVGCSGDATVVTVRNKKRIGYSFDITLGFQGSLl----- 125
XP_002508349   80 ERGHTDWAKARVEELVVgktidVA-GGg-------AAVVKeVKTFKGDATVVMVRGKPRHGFDFDVTLAWECTFeg---- 147
XP_001419417   70 ERGHTDWARARLETLVVergkfDLdGAfag---vvARVVG-VKKCEGDASVVMIRGKPRHGFDFETTLEWRASFaeedge 145
Q012W8         68 ERGHTIWAKARIEELVTengtfELvGGngidadarVRIVG-VKSCEGDASVVMIRGKPRRGFDFELTLNWEAAFasgg-- 144 Ostreococcus t...
XP_002955092  199 ERGATCWAKSRLTELIRerelpGGg----------VTVVD-VNGCEGEANIFIVRGKKRCGFDFELQLAWKAVPr----- 262
24_pfamImport   1 ERDKSGWARERLKHHILtsfsfdd-----eaeglgVKATS-IVRCDGEAKVVFSRGKKRCGYDLSVKFAWA--------- 65 

1USV_B         95 --------SKDGSalpFEGSINVPEVAFD-SEASSYQFDISIFKe-----TSELSEAKPLIRSELLPKLRQIFQQFGKDL 160 brewer's yeast
XP_009132083  128 -------eEETKK---VKGSLDIPEFSFGeLDDLEVD--VKLSDdke-lsQQLKQQIRLDMKQ-FLEPIRLKLDQFEQEL 193
XP_002453280  136 -------kEENKK---IKGHLDIPEFSFGeIDDLEVQ--VRFSDdkg-laSEDKTRICKDLKT-FLASIQEKMRVFEEEL 201
XP_002976673  134 -------vGEPFQ---VEGTLSV-DTCLGdLDDLRID--VAFTEvpetlpEPEREHLRSQMSQ-FLPKIRTQLECFEKEI 199
XP_002979005  126 -------fDEFKD---LTGTLKFLDASCGeLDDLQIE--VDFTKdeg-lpAAEKNRLAKELES-FLPRIRETLLSFEHEL 191
XP_002508349  148 ------dgEDVKP---VKGTVHIPEASRDtVDDDEVEYTVKVEDrkt-drRSQEDAAYDALKGGLRTFLRETFGTIDKEL 217
XP_001419417  146 dgededgdEAAVE---VQGTIHIPEFSRDcAEDEECAFEIKVENrkk-ehREREDACYAALKKSCEEFIVGVLRQIDDEL 221
Q012W8        145 -----gddEQEVI---IKGTVHVPEFSRDgVEDEECACEVKVSDrns-ehAPRENACVATLKKRCEDFLVRTLMTIDSEL 215 Ostreococcus t...
XP_002955092  263 --------PGAIE---IRGHCKVLNFSSDdPEDLELHPEVAHRQpd---rAADEAIALDQVRAVLRPELIKILTQLLEEL 328
24_pfamImport  66 ----------SGD---VSGHVELHDF--DdTSADEFEIIVTADGssq-seVAAKKAVIDKE-----PELRKLLALWKEEL 124

1USV_B        161 LATH 164 brewer's yeast
XP_009132083  194 KDRQ 197
XP_002453280  202 K-GR 204
XP_002976673  200 KELV 203
XP_002979005  192 K-DR 194
XP_002508349  218 LARA 221
XP_001419417  222 CERA 225
Q012W8        216 EERA 219 Ostreococcus tauri
XP_002955092  329 K-AK 331
24_pfamImport 125 LQ-Q 127
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