1USV,3N72


Conserved Protein Domain Family
Aha1_N

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pfam09229: Aha1_N 
Activator of Hsp90 ATPase, N-terminal
Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity.
Statistics
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PSSM-Id: 401244
View PSSM: pfam09229
Aligned: 222 rows
Threshold Bit Score: 50.2284
Threshold Setting Gi: 122102507
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1USV_B        27 DkNCIGWAKEYFKQKLVgveagSVkDKk--YAKIKS-VSSIEGDCEVNQRKGKVISLFDLKITVLIEGHVd----SKDGS 99 
XP_004037345  20 QkNYTSQANKILEEIFLslnleQD-GIq---IKHSK-IKSITGDAEINVRKGKQILCYDFNIEVEFIGQ------NQEEE 88  Ichthyophthiriu...
CDS44927      15 EkNYNKWGESYIKSKLIhlkieDEn------LSIYFdTINITGNASVSIRKGKQISSFEFVIKFKWNCLRk---kENINS 85  Plasmodium berg...
CAQ39755      15 EkNYNKWGESYIKNKLSdlkieKEd------LSVYFdRVDISGNASVSIRKGKQINSFEYVIKFDWVCSKt---gQDKEY 85  Plasmodium know...
O97244        15 ErNYNKWAESYIKYNLSnlkieKEd------LTIYFdNLQVSGNACVSIRKGKQINSFEYIIKFEWLYSKk---kEGKDY 85  Plasmodium falc...
ESS29672      18 EkSYTKWSREYLQARLGslklvEDvDGf--SVTTLP-TPAVSGEASVSVRKGKTILAVDMAVKLQFEAQLk---qDGNRK 91  Toxoplasma gond...
XP_002141372  18 EkNYDKWGKEKLKSMIEafeykFP-PPnenLVIHLS-CTKVSGEASVSVRKKRPILAYEFEITANWLARYs---dNNDKC 92  Cryptosporidium...
O97244       211 EkCLTKWAIEELQNIFNksiieLS-NN----IFLEFfSCDVEGEASSSLRKKKKILMYDLKITSEWKAYQknknqQIEIE 285 Plasmodium falc...
3N72_A        19 ErNYNKWAESYIKYNLSnlkieKE-Dl---TIYFDN-L-QVSGNACVSIRKGKQINSFEYIIKFEWLYSKk----KEGKD 88 
XP_002258982 217 EkCLTKWAQEELKNMLDtstiqLS-NN----ISLQLfSSEVDGEASSSLRKKKKIIIYDLKINTEWKAFKknkngQVEME 291 Plasmodium know...
1USV_B       100 alpF-EGSINVPEVA-FD-SEASSYqfdISIFKe-----------TSELSEAKPLIRSELLPKLRQIFQQFGKDL 160
XP_004037345  89 ---C-EGYYKVHGIN-PD-----DDdfeVDHITln--------skNKCGEMTKKILLKKLKGELTKVLKDLPKKI 145 Ichthyophthirius mul...
CDS44927      86 ---F-GGDVEILDFS-NCsLEDNDYeinVEANEs-----------NADMKKAYEILRKEGKEKIKNTLKDFQLEL 144 Plasmodium berghei ANKA
CAQ39755      86 ---A-GGTAEILDFS-NCsVEDNDYainIELIGd-----------KEESKRAYEILRKEGKEKIKDALKNFPEDL 144 Plasmodium knowlesi ...
O97244        86 ---F-GGSVEIPDFS-TFsLEENDYainIERTDe----------sENLRFIYDSILKKEGKEKIKECLKNFQEDL 145 Plasmodium falciparu...
ESS29672      92 ---C-RGEISVTDIS-SEsVEDRDYt--TSARLtdvdlpaaeamtAEERQKALAIVKRNGMNAVHAALERFIKDL 159 Toxoplasma gondii VEG
XP_002141372  93 ---L-TGSLTIPEFS-VDnYQE-LYpikISSNLd----------lGEMSNLVVKEVNNSLVSELRNYLKRFHDLL 151 Cryptosporidium muri...
O97244       286 ---S-KGHVSINDIL-SDfSSD---------DNtkysyyfifdnkTDEYNQINDVIKLEGPNKINQIIDDFILKM 346 Plasmodium falciparu...
3N72_A        89 ---YfGGSVEIPDFStFS-LEENDYainIE-RTde---------sENLRFIYDSILKKEGKEKIKECLKNFQEDL 149
XP_002258982 292 ---I-TGHVIVNDVI-SDfSSQ---------EDskytfqfifdnaRPEAADMNEVIKNEGPAHIEKIIEAFISKM 352 Plasmodium knowlesi ...
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