Conserved Protein Domain Family
Colicin_immun

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pfam09204: Colicin_immun 
Bacterial self-protective colicin-like immunity
Colicin D, which is synthesized by various prokaryotes, adopts an antiparallel four helical bundle fold: the helices are tightly packed, forming a compact cylindrical molecule. The protein specifically cleaves the anticodon loop of all four tRNA-Arg isoacceptors, thereby inactivating prokaryotic protein synthesis and leading to cell death. This family also contains immunity proteins to klebicins and microcins. Many bacteria produce proteins that destroy their competitors. Colicin D is one such. The immunity proteins are expressed on the same operon as their cognate bacteriocins and protect the expressing bacterium from the effects of its own bacteriocin.
Statistics
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PSSM-Id: 401227
View PSSM: pfam09204
Aligned: 6 rows
Threshold Bit Score: 101.777
Threshold Setting Gi: 501216042
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ACE06483                17 YIYLLGLFVSNQIDISSFEDLFLKI--RREDNYWLSgLFNNKIGKVLDSLFLDVDEYTPDCLfDPNNKFTinETELKKRA 94  Candi...
WP_015696191             5 LLTFARSFINGEISAEDFADPYQMLwkTEGENGDSL-KDNDQDSEKCSTIFCLADQFNPDND-REKDEFD--ADELKARV 80  Rahne...
CAP40934                 5 LLEFAKSFVEGRISAPVFSEAYMELwkIERDSGSLI-RDESALSERLSSIFCAADMYNSDSEsREEYEFD--DEQLRFEV 81  Borde...
SLUandSVAtrep:TPE_2169   6 YIKLITKFIDNAIDAKEFEQSFLEMfkTEQE------KISEKDYLVLDSLFGDVDMFCFDSElFEEGDLT--ESDLRKSA 77  Trepo...
WP_002214798             5 ILEFAKSFINERVSAQVFANAYIEFwrIERDQRICL-KDNEKLNECLSSIFCLADLYNPDSD-REEYELD--DKQLYEQV 80  Yersi...
WP_012259060             6 YKRLIEAFLTHEISAAEFEERYMAAflAEPG------GMDKELFLILDALFAAVDCYWPGCApGEETPFEisEEQLRREA 79  Chlor...
ACE06483                95 SESLN 99  Candidatus Amoebophilus asiaticus 5a2
WP_015696191            81 RAVLD 85  Rahnella aquatilis
CAP40934                82 CKLVE 86  Bordetella petrii
SLUandSVAtrep:TPE_2169  78 EQTLE 82  Treponema pedis str. T A4
WP_002214798            81 LQLIN 85  Yersinia pestis
WP_012259060            80 RDALA 84  Chloroflexus aurantiacus
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