Conserved Protein Domain Family
Act-Frag_cataly

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pfam09192: Act-Frag_cataly 
Actin-fragmin kinase, catalytic
Members of this family assume a secondary structure consisting of eight beta strands and 11 alpha-helices, organized in two lobes. They are predominantly found in actin-fragmin kinase, where they act as a catalytic domain that mediates the phosphorylation of actin.
Statistics
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PSSM-Id: 370352
View PSSM: pfam09192
Aligned: 7 rows
Threshold Bit Score: 282.843
Threshold Setting Gi: 332005821
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004031008      55 KEFNFATLPIKniRKFNWEEIRAVAISQSGTQ-------------------GVIFVESDEG------------------- 96   Ichthyopht...
A0BPQ4           475 KEFNFASKTLT--KKIVWSDLRAIALSDSLDK-------------------GAIFVETNEG------------------- 514  Paramecium...
A0DCH7            35 qEFDYSAKPYVdfEYIKLKQIKSIKLSDSGSR-------------------GVLFIDSENG------------------- 76   Paramecium...
JCVI:AT5G23720.3 102 ERLGKASTVDIdsSCFSWNMLSSLHHTEHSSStdhseedqskplevtvnsgGVVFFALFNSssseda------------- 168  thale cress
Q54WK1            97 SYI--PMIQYSniHCIDWSSLISVDKLDLGSS-------------------NIFLIATFLNnkc---------------- 139  Dictyostel...
Q55EN5            76 LNINNQEFITSniLEIDWNTIIDIEIIDFGNS-------------------IVCLLVTLSSdnl---------------- 120  Dictyostel...
Q55EU4            58 TNIDYNIPTFSniQNIDWKSISSVEKIDFGNS-------------------NIFLLITFNNnnninninnlncncvnnnn 118  Dictyostel...
XP_004031008      97 -----------------------------AIVVKGSSD---MAIDFFLYKLARVMNVNVPTLRIVRYYDQEFDLI---LH 141  Ichthyopht...
A0BPQ4           515 -----------------------------SVVVKGYPN---IAQGYFFSQLAIVLGIPVPNKRIVRWDSSEFKVL---TK 559  Paramecium...
A0DCH7            77 -----------------------------AIVLKLSGQ---VSVELYLNKLAQALDIKTTQMKCLKWLDLEMQEL---RN 121  Paramecium...
JCVI:AT5G23720.3 169 ------------------------srkeeAAVIKFASSrmaTQSERLGYEFSKWLGVQIPQARVIHSCNPEWTLIkeaTE 224  thale cress
Q54WK1           140 --------------------------eynQVLLKSSTT---IVQEVYASVLESILKLPIPEMRLLEYSNDEYIQM---SR 187  Dictyostel...
Q55EN5           121 --------------------------hfnQILIKSTPT---IAQECYASVLQNILKLPILDLRLLE-KNNEFLEM---SS 167  Dictyostel...
Q55EU4           119 nnicnnncinnnnntndenpsiinnynesQILLKSSST---IAHDVYAYVLEGILKYPIPEMRLLDFSNLEYTEM---SY 192  Dictyostel...
XP_004031008     142 NLQ-RATFCDEVLGRRVSSRLDMPF-----LQVMEYIPGISV-------EQMGPHRAalifdhitpesRDRLIRLGMILA 208  Ichthyopht...
A0BPQ4           560 ELQ-RATFMLKQLHQKITNRLENPY-----LEIQEYLPGITL-------SYMGKARAgkifnfydpqsRHRLIKVGFLMG 626  Paramecium...
A0DCH7           122 DIL-FAASSDEVLSHRLKQKLKAAY-----FEMVEYVPGLQL-------YYFQGERAkii------fnQERLFSLGKIIG 182  Paramecium...
JCVI:AT5G23720.3 225 KAQaKATSEGDEVGEMTCSELLEALelsrcLLLMSYVHGCPMles--msSFETEEKA-----------ERAAAALGRILV 291  thale cress
Q54WK1           188 SLLtISSKTNKSLYDYIKLELLKSF-----FLIMEYAPNGKSfkdldykEYFSGYGG-----------EKKLNQLGQVIA 251  Dictyostel...
Q55EN5           168 NLL-DFSKDDQFLNDFIKSEFEKTF-----FLIMEFRQNGKKfnelnhkEYFSGYKG-----------QEKFKQLGKIIA 230  Dictyostel...
Q55EU4           193 NLL-IHSKDDQSLNDFIKSELEKSF-----FLILEYRNNGKRfnelnhkEYFSGSKG-----------GKKFKQLGKIIA 255  Dictyostel...
XP_004031008     209 FDTLINNSDRYPL---IWDG-DGNAANIIVKMMTnflTKTEQLKDINNLNID------FEKFYAIDSGWGQVNttneqgl 278  Ichthyopht...
A0BPQ4           627 LDIFINNPSRFPLe--IWKN-SGNSEHMIVRTEPrytDTTKDLHDIDNLSFD------YEYIYGLDSYSFERP------- 690  Paramecium...
A0DCH7           183 FDIFIHNGDRFPLp--IWRS-VGNAYNVILKVID---EKQEDMFNFNNTNLN------FECFYSIDPQTILKQhdssiqd 250  Paramecium...
JCVI:AT5G23720.3 292 LDLVIRNEDRLPCrqlRWR---GNPANLLLT------DRIVSSAKHHECSFDeafdsaIKRYHPKDYRSIQRErras--s 360  thale cress
Q54WK1           252 FDIFCNNSDRLPL---IWDNvSSHFSNILFYDIP---NRNGWYISLMNSNVTcinnssFTIGY----------------- 308  Dictyostel...
Q55EN5           231 FDIFCNNFCKTNIa--GDDS-SIYFSNIICYETP---NKNGWYFSLINSNISclnnslFTIGY----------------- 287  Dictyostel...
Q55EU4           256 FDIFCNNFCKLPSpplNWNS-STFFSNILCYDSP---DKNGWYFSLINSNISflntspFTIGY----------------- 314  Dictyostel...
XP_004031008     279 kalQIYYNKLEDFLSSLFEDMkqvmmaqidplteigkdgKKKASSCLNKITNYLYNYTLYHLSEMQVFQIMLGIITGI 356  Ichthyophthi...
A0BPQ4           691 ---PSYYTNVEEFLNKVFLEMksimqaq----ldplyetKDQKIECLNEFKQLVYDHTLYEIKEMSLLQVLLGIVLTI 761  Paramecium t...
A0DCH7           251 kilNAYIEKVQKFLQDLCDDI------------------KTNELNCLETFEDFIFEQIQYKLSKEELLIVKKGILYqi 310  Paramecium t...
JCVI:AT5G23720.3 361 vdsRSRLSISDQMLVSQASDFsdit-----------espRSYDTGLMSPMSDRSVA------ADFHLVAIDSGvprrp 421  thale cress
Q54WK1           309 ---RKYITRVKSILYALFKR-------------------PNIESNQIKKMRESISKSYKINLSSSCGISIQRGIIQGV 364  Dictyosteliu...
Q55EN5           288 ---RYHMNSLKLLLFSIFQN-------------------PSTESFQIRMMREHLLKKLNIKLPKSSAVYIQKGIAKGI 343  Dictyosteliu...
Q55EU4           315 ---RDHLNRLKLLLFSIFQN-------------------PSTESVQIKLMRDHLLKCQGIKLSGSSVSYLQKGIAKGI 370  Dictyosteliu...
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