Conserved Protein Domain Family
PPP4R2

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pfam09184: PPP4R2 (This model is not part of the current CDD release)
PPP4R2
PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.
Statistics
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PSSM-Id: 518740
Aligned: 22 rows
Threshold Bit Score: 171.509
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003672191   6 ELNSSIHNMMGIKSRRLYEYLNDILITKKVKLSNSSNEPIPFDLLINdFIPHMIDVTPN----------ESFInsneeni 75 
EFA02661      10 SLEEFSKTKPKDIPRELEEYLCFVAKTGDPVYQWSAIKSLFREKMIN-VITEFYETCPSveipp-cpnvDIFN------- 80 
XP_001688384  12 LLERFTKSKQKDIPRELEDYLNFVARTGDTLYRWVLVKPLFREKLVN-VITDFHHNTPSiadipqcpnvDPFN------- 83 
XP_001966216  13 ILERFTRLKQKEIPKELEDYLQYVAKTGDTIFKWSSLKYLFREKLLN-VIKHFNEDSPRleeipnypnvDPFN------- 84 
XP_002064314  13 ILERYTRLKQKEIPKELEDYLQYVAKTGDTIYKWSTLKHLFREKLIN-VIKNFNEDSPLleeipnypnvDPFN------- 84 
XP_015016960  13 ILERFTQLKQKEIPKELEDYLQYVAKTGDTVFKWSSLKYLFREKLLS-VIKHFNEDPPRleeipnypnvDPFN------- 84 
Q9W2U4        13 ILERFTDLKQKEIPKELEEYLQYVAKTGDTIFKWSSLKYLFREKLLS-VIKHFNEDSPRleeipnypnvDPFN------- 84  fruit fly
XP_014331120   9 AFQDFEKRGKKETCPALEQFLCHVAKTGQPMIPWLQFKTYFLFKLDK-VMEDFHASAPEerdsh-npnvEYIP------- 79 
1_pfamImport   4 AFRDFEKTGKKETCPELEQFLCHIAKTGQPMISWSQFKTYFAFKLEK-VMDDFHASTPEqrarh-npnvDYVP------- 74 
XP_003439001   9 AFQDFEKKGKKETCPLLEQFLCHIAKTGQPMIPWSQFKTYFMFKLEK-VMDDFHAATPEqrgph-npnvEFVP------- 79 
XP_003672191  76 esirrLKEMGENLIDKFFNNEKLPFTIMRIFELCFDPFKYFKvnELVKYVNALEKCCYVDSCLTLASSSssstnteerrd 155
EFA02661      81 -----YDLMKNFILEKLDTFAAAPFTLQRICELLTTPRKEYN--RIDKYMRALEKNILVVSTTEPGGRR----------- 142
XP_001688384  84 -----FERMKRALLERLDSFNSAPFTVQRICELLTEPRKQYT--RIDKFMRAVEKNILVVSTQEPGRRRsd-------se 149
XP_001966216  85 -----YETMKSTLLERLDLFNAAPFTVQRLCELLIDPRKQYS--RIDKFMRALEKNILVVSTIDPGRKRte-------se 150
XP_002064314  85 -----YETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYS--RIDKFMRALEKNILVVSTVDPGRKRte-------se 150
XP_015016960  85 -----FETMKASLLERLDLFNAAPFTVQRLCELLIEPRKQYS--RIDKYMRALEKNILVVSTIDPGRKRtd-------sd 150
Q9W2U4        85 -----YETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYS--RIDKFMRALEKNILVVSTIDPGRKRte-------se 150 fruit fly
XP_014331120  80 -----FEEMKNRILKIVDGYNGIPFTIQRLCELLTDPKRNYS--GTDKFLRGLEKNVMVVSYLHPTSEK----------- 141
1_pfamImport  75 -----FEEMKARILKIVDGYNGIPFTIQRLCELLTDPKRNYT--GIDKFLMGLEKNVMVVSCVGPTSEK----------- 136
XP_003439001  80 -----FEEMKTRILKIVDGYNGIPFTIQRLCELLMDPKRNYT--GTDKFLRGLEKNVMVVSCIYPTSEK----------- 141
XP_003672191 156 EEESNGNTIGE--------------------------------------------------------------------- 166
EFA02661     143 NTENGEGIMNGlesehlpetsnssndinveemddapawprllqnenvpyqnensnsndiqtqpivqetvvtasklpdvac 222
XP_001688384 150 NGDSLDSIVNGdlevnvdiemdneq----------------------------------------------------fhl 177
XP_001966216 151 NGDSLDSVVNG--------------------------------------------------------------------- 161
XP_002064314 151 NGDSLDSVVNGdlslevnidiemenenl-----------------------------------------------fnngn 183
XP_015016960 151 NGDSLDSVGNGdislevnidiemenen-------------------------------------------------ifnn 181
Q9W2U4       151 NGDSLDSVVNGdlsmevnidiemenn---------------------------------------------------ngn 179 fruit fly
XP_014331120 142 NGTSTMNRMNGvmflgnpslyse--------------------------------------------------------s 165
1_pfamImport 137 NGASSVNRMNGvmfpgnsslysd--------------------------------------------------------- 159
XP_003439001 142 NGASSINRMNGvmfpgnsslyt---------------------------------------------------------- 163
XP_003672191 167 -----------DGDASLVKIPWITEKDMG-QLLPIVKEIdvimnvefdDDDEDDDEEddeehhdvngqgtirerksnkHG 234
EFA02661     223 sssqdtvitcrSSEEPYVSIEPVPSNTCT-RSDPDETDVsvtitaipaGVQKRRNSV---------------------EP 280
XP_001688384 178 eadallpdssdAVGSLHGSLGSEVGTASSaQRTADGNEVngggsfmnsDGGTSQPSSkgglssephe-gvidtnenatDG 256
XP_001966216 162 ------------DLSLEVNIDI---------------EMeneasfnngNAEEGSAPS---------------------SG 193
XP_002064314 184 ageenssgagaGRTAVMSPCRRTLPDEGE-LPKAKKAKLdv------nDDEERG--S---------------------DA 233
XP_015016960 182 gddrnvpieetNCIAMKASCPRSDDSAAA-PPKAKKAKLdf------dENEQRD-EE---------------------DA 232
Q9W2U4       180 adegsspgagsAGCAQKASCPRSDDND---QPKAKKAKLei------dGEERSEASD---------------------ET 229 fruit fly
XP_014331120 166 srnvngpslskTLNRPKLS-SSSLSTNGL-PECPASKEPd-------gITETEEQHS---------------------SE 215
1_pfamImport 160 srnvngpdtpkPLNRPKSSLTSSLSTNGL-PDCPVSREPi--------TEEVEEHHS---------------------GH 209
XP_003439001 164 drnvngpgtpkPLNRPKLSLPTSLSTNGL-PDCPVSKEPep------aTEEVEEQGI---------------------SE 215
XP_003672191 235 GTSTDDIsitlQNDKDFIIEEyyeddddddddmnvedtnknltntpdDEEEQDDDYVDD---NMGDTSGDDDDDDADEND 311
EFA02661     281 VVSSETEeiteSCDQSDKTSEpsk---------------------esEAKQEETPSSQQiedADSSSSAEDDKESVESKE 339
XP_001688384 257 DIAAPLLeaslEASSSSAPTTasa---------------------vaERTEKSN--------EIEPAPLQEEAESTATED 307
XP_001966216 194 SGALKAScprsEGGPQPKAKKakl---------------------efEGDEEAADASSK---KSDNDETDARQEAAEIEE 249
XP_002064314 234 TAAASAGdasaATAAGNDVKS--------------------------KNGNDNND---D---EVDARPRQELPEIAEPDE 281
XP_015016960 233 EEADEEVatmnSKSKADKAKA--------------------------ETADEDRDLKTD---VT--EAAREIPEIEEPDE 281
Q9W2U4       230 D----TEvatrVK----------------------------------NEKDEKND--ND---ET--DSPHEAAEIEEPDE 264 fruit fly
XP_014331120 216 TPPSEDEa---KPKHGIKHKH--------------------------REEDEESDCDKQ---EAKKRKTGEYDDETEREE 263
1_pfamImport 210 SSSAEGEe--iTPNSGIKNKHp-------------------------AEEEEDYETGEH---EVKRLKFDEKEEDERESE 259
XP_003439001 216 TSLSEGEm---TPNSGIKNKH---------------------------PEEEDSDGDKQ---EVKRLKFDETEENETTSE 262
XP_003672191 312 END 314
EFA02661     340 EKt 342
XP_001688384 308 KEN 310
XP_001966216 250 PDE 252
XP_002064314 282 EVE 284
XP_015016960 282 EEE 284
Q9W2U4       265 EVD 267 fruit fly
XP_014331120 264 NES 266
1_pfamImport 260 ENE 262
XP_003439001 263 KNE 265
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