Conserved Protein Domain Family
STN1_2

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pfam09170: STN1_2 
CST, Suppressor of cdc thirteen homolog, complex subunit STN1
STN1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required for protecting telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity on their own. In addition to telomere protection, the CST complex probably has a more general role in DNA metabolism at non-telomeric sites.
Statistics
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PSSM-Id: 401202
View PSSM: pfam09170
Aligned: 24 rows
Threshold Bit Score: 201.358
Threshold Setting Gi: 47223996
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003218541 159 DPAYEVQIARLLELPRLYRDIYDKPFQIPEETKSQGVASL-------FGSVSVLSE---KIRAFL-LRNKIQSFYKQDLE 227 green anole
Q6DJ48       159 DPKLDIQMARMFDLPYMYRNVYDKPFAIPEHLKDSSAGQTdhhivtqSHLIMLLSE---KVKVFL-MENKIHNFYQRELE 234 tropical clawed...
XP_002599121 171 DPTCSIEINRTMKQLQLYQDFYDVPFQRGNGDSGDCTG---------AGVVKSLQD---AIADFLnTSSTVLNFEIKELA 238 Florida lancelet
XP_015202900 165 DPVLAVQISRMMEVPQLYRRFYDKPFQVPHGLQERSSDCDle---gvTSLPSLLGQvclSLKDFL-RKEAVQSFHPNDLE 240 spotted gar
XP_007251425 160 DPVMDVQIARMLEIPQLYRDCYDKPFQALGSEVEASTTDAgg----hPNFQSLLGQsvrILKKFL-KEKEVAKFRPYDVE 234 Mexican tetra
B8JKF4       164 DPAMAVQISRMLELPQLYRKCYDQPFKMPSD--DLGSTEAgg----sSHPQYLLSRavlTLKEFL-LEKEVTRFRPYDVE 236 zebrafish
XP_005470224 139 DPVMAVQISWMMEAPQLYRQCYDKAPQL--------EPDAa-----gDSAVSSLSRatkILKDFL-KQKSVSRFRPYDVQ 204 Nile tilapia
XP_028451311 165 dpvMAVQIAWMMEVPQLYRQCYDKPPQL--------QPTAt-----gDSGISSLSKatnTIKDFF-KQQSVSRFRPYDVQ 230 yellow perch
XP_023190121 165 DPVMAVQIAWMMEVPQLYRLFYDKRFQL----------DVa-----gDSAETSLSKatnVIKDFL-KQRLVAKFRPYDVQ 228 southern platyfish
CAG06173     172 DPMMAVQIEWMMEVPELYRQCYDKPFEV--------QPDAs-----gEPAVSALSKaanIIKEFL-IQKSVVRFRPYDVL 237 spotted green p...
XP_003218541 228 TVEEFVDLIRQ----GTAAEQTDSKPHSFSSLIRESFLEAiRILENKGVLFQKSKNPNDMYYVTEQDRELHRVTLKVLKE 303 green anole
Q6DJ48       235 SVDSLIAIASRpvsdFKTIESMESS---NSKQIRSIFKEAiQLLLKEGYIFQK-DQNREVYQVTDQDKDLHKLTLNIIKE 310 tropical clawed...
XP_002599121 239 TVDSLMAVVEKarkeNESAM--------TAKQVNSLFTQAvGGLEDLGLVYKR-TDKDNLYVVVDRDETLESNVLEIVRR 309 Florida lancelet
XP_015202900 241 TVNSLVSLASHdlqnGPDQQQAARSLS-TSKQIHSVFREAiQVLQEEGLLFRKAGSQEEVYQVTEQDKELHRVTKEIICE 319 spotted gar
XP_007251425 235 YL--LHPLIQWpprnTASGQEVTSAGPSFSTQVKNLLKETlKILQSEGEIFRKVLSPDELYNVTEQDKDLLAAIRDMIRE 312 Mexican tetra
B8JKF4       237 FL--LHPLIQR----SSAEQEADQPGTSFATQVGKLLKETlSFLQDEGQIFRKKRTQDEVYNVTEQDKDLHIAIKDVLRE 310 zebrafish
XP_005470224 205 DL--LQPLISSqpqaASADQEP-VAGPSACQQLRQLLKEAlQILQDEGAVYRKVKSQDEVYLVTVQDKDLLVAVKDIIRE 281 Nile tilapia
XP_028451311 231 DL--LQPLISSqpqtASANQEP-VAGPSACQQLRQLLKEAlQILQDEGIVYRKVKSQDEVYHVTAHDTDLRIAVKDIIRE 307 yellow perch
XP_023190121 229 DL--LQPLISSrlqaQEA-----VAGPSGCQQLNQLLKEVlQVLQDEGTVYRKVKSQDEVYHVTIQDKDLLIAVKDIIRE 301 southern platyfish
CAG06173     238 DL--LEPLVPRqprtESADQ-P-MAGPSACQQLRQLQKEAlKVLQDDGVVYCKFKTQDEVYHVTVQDKDLIIAIKDIIRE 313 spotted green p...
XP_003218541 304 DCKRPKYAEKGCHLRHIHNCVNQ 326 green anole
Q6DJ48       311 DCRRQKHAEKGCHFLHILTCVRL 333 tropical clawed frog
XP_002599121 310 ESQNPKYSESGCHYRHVLDCLRT 332 Florida lancelet
XP_015202900 320 DSRREKYAEKGCHFLHILSCVRQ 342 spotted gar
XP_007251425 313 DSKREKYAEKGCHVLHILSSVRQ 335 Mexican tetra
B8JKF4       311 DTKREKYAEKGCHVLHILSSVRQ 333 zebrafish
XP_005470224 282 DSRREKYVEKGCHVLHILSAVRQ 304 Nile tilapia
XP_028451311 308 DSKREKYAEKGCHILHILSAVRQ 330 yellow perch
XP_023190121 302 DSKREKYAEKGCHILHILSAVRQ 324 southern platyfish
CAG06173     314 DSKKEKvkmqfrtvldvkvvdve 336 spotted green pufferfish
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