1MJE


Conserved Protein Domain Family
BRCA-2_helical
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pfam09169: BRCA-2_helical (This model is not part of the current CDD release)
BRCA2, helical
Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.
Links
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Statistics
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PSSM-Id: 518731
Aligned: 13 rows
Threshold Bit Score: 254.227
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1MJE_A         25 MSSLQSARDLQDMRIKNKER--RHLRLQPGSLYLTK-SSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNA 101  house mouse
2_pfamImport    1 IASLHCARNLQEMRILKKQK--QVIGPQPGTLYLMKiCATSCRIPLKTAVDEKCPGSYFSEQLYAFGVSKQCLNVNSSNA 78  
7_pfamImport    1 IQNLDFARGMQEMRIRKKKR--QTIRPLPGSLCLTK-TSGVSRVSLRAAVGGKSPAQHTQQQLYVCGVNRCVLEISSENA 77  
3_pfamImport    1 LPNVELAQDMQDMRIRKKKR--QTIRPLPGSLFLTK-TSGVTRIPLKAAL-------VFLLQLYRHGVHQHVCEISSETA 70  
6_pfamImport    1 LESLELARDMQDMRIRKKKS--QTIRPLPGSIYLAK-TSGVTRISLREAVNNKCPLLHSQEKLYQYGVHCQVSQITAENA 77  
XP_031753097 2288 TSNLRCSKDLQEMRIRKKLR--QKIKPHPGSLYRLK-MSHVKRISLQSAVAERCPTLYSREQLYRYGIVKNHIGVSSENA 2364
XP_031816586 2449 NKNLQNARELQDMRIKKKQT--QQIYPQAGSLYLTK-TSTIPRISLKVAVEGRVPSTYSSKQLYMYGVSKQCSRINSKNA 2525
P51587       2481 ITSLQNARDIQDMRIKKKQR--QRVFPQPGSLYLAK-TSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNA 2557 human
P97929       2402 MSSLQSARDLQDMRIKNKER--RHLRLQPGSLYLTK-SSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNA 2478 house mouse
XP_001863104  946 LDARRLARERQRECGDGRTKpeQERRPRLYEFVRRK-KQQSGRISLRAFVGGERVGGGAGDGGSSRGVAERIRMLSVDNV 1024
XP_068069673 2024 QESLQLARDMQDMRLRKKKR--QTIRPVPGSLYLAK-TSGVSRKSLRDAVGCTCPSQYTQDELSQHGVHHKVLEITSENA 2100 zebrafish
XP_011606993 1865 LHHFQLARDMQDMRIRKKKR--QTIRPLPGSLFQKK-SSGVARIPFKAAVNGKPPARYTAKPLCGLGVPLNVLEITSETA 1941 torafugu
XP_064413020 2719 TANLQCARDLQEMRLRKKQR--QNIRPQPGSLYLAK-TSGVARVSLKAATGNQCPSSYSTEQLYVHGVGKSTLKVRSENA 2795 coelacanth

1MJE_A        102 EYFQFDIQDHFGKEDLCAG-KGFQLAD-GGW--LIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVWKLAA 177  house mouse
2_pfamImport   79 EHFQFHIQDFFGRECFLDG-NGIQLAD-GGY--LIPTDDGKAGKEEFYRALCDTPGVDPKLISKAWVYNHYKWIIWKLAA 154 
7_pfamImport   78 ESFRFSCRDHFGIEFFSAG-NGVQLAD-GGC--LIPDNKGTAGKEEFYRALCDTPGVDPKLISESWVYNHYRWIVWKRAA 153 
3_pfamImport   71 ESFRFNLKQFIKREALLDG-GGVQLAD-GGW--LIPSKDGTAGKEEFYRALCDTPGVDPKLISDGWVDNHYRWVVWKQAS 146 
6_pfamImport   78 ELFRFNFDDFFKREMFIDN-TGVQLAD-GGW--LIPDNRGTVGKEEFYKAMCDTPGVDPKLMSEAWVFNHYRWVVWKRAC 153 
XP_031753097 2365 LSFQFHCSNYFTKELLLSG-NGVQLAD-GGW--LIPTEQGNAGKEEIYRAFCDTPGVDPKLISAEWVHNHYRWIVWKLAA 2440
XP_031816586 2526 ESFQFHSQDYFSKEYLLDG-NGIQLAD-GGW--LIPTDEGKLGKEEFYRALCDTPGVDPKLITKTWVYNHYRWIIWKLAA 2601
P51587       2558 ESFQFHTEDYFGKESLWTG-KGIQLAD-GGW--LIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAA 2633 human
P97929       2479 EYFQFDIQDHFGKEDLCAG-KGFQLAD-GGW--LIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVWKLAA 2554 house mouse
XP_001863104 1025 AEFKFEVEAFYGKQFAQENtTGIPLGDpDALihVILDDNSHVGLPEFTSAFLAAPGIDPTLVPSGWIVNAWKWILLKLAS 1104
XP_068069673 2101 ESFRFDCSDYFTCEHLMES-GALQLAD-GGW--LVPDSKGTVGKEEFFSALCDTPGVDPKLISDVWVFNHYRWIIWKRAS 2176 zebrafish
XP_011606993 1942 ESFRFSLQHFVKLEPLMDK-GGIQLAD-GGW--LIPTNDGTAGKEEFYRALCDTPGVDPKLMSEEWVYNHYRWIVWKQAS 2017 torafugu
XP_064413020 2796 ESFQFSCSDYFGKDVLLAG-NGLKLAD-GGW--LIPSDKGMVGKEEFYRALCDTPGVAPKLISESWVYNHYRWIVWKLAA 2871 coelacanth

1MJE_A        178 MEFAFPKEFANrCLNPERVLLQLKYRYDVEIDnS 211  house mouse
2_pfamImport  155 MEVAFPQEFASkCLTPERVLLQLKYRYDVEVDkS 188 
7_pfamImport  154 MERAFPLEMGSrCLTPEQVLLQLKYRYDLEIDnS 187 
3_pfamImport  147 MERSFPETMGGlCLTPEQVLLQLKYRYDVEVDhS 180 
6_pfamImport  154 MERTFPEVMGGrCLTPEQVLLQLKLRYDTEVDnS 187 
XP_031753097 2441 MEVRFPKTFACrCLTPERVLLQLKYRYDVEIDkS 2474
XP_031816586 2602 MEFTFPKEFASrCLTPERVLLQLKYRYDIEIDkS 2635
P51587       2634 MECAFPKEFANrCLSPERVLLQLKYRYDTEIDrS 2667 human
P97929       2555 MEFAFPKEFANrCLNPERVLLQLKYRYDVEIDnS 2588 house mouse
XP_001863104 1105 MERQLPKLFCD-VTSPVNVLDQLLFRYHVEID-C 1136
XP_068069673 2177 MERTFPNLIGGlCLTPEQVLLQLKFRYDVEVDhS 2210 zebrafish
XP_011606993 2018 MERSFPEEMGSlCLTPEQVLLQLKYRYDIEVDhS 2051 torafugu
XP_064413020 2872 MEAAFPKEFGNrCLTPERVLLQLKYRYDIEVDkC 2905 coelacanth
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