Conserved Protein Domain Family
Biliv-reduc_cat
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pfam09166: Biliv-reduc_cat (This model is not part of the current CDD release)
Biliverdin reductase, catalytic
Members of this family adopt a structure consisting of four alpha helices and six beta sheets, in an alpha-beta-alpha-alpha-alpha-beta-beta-beta-beta-beta arrangement. They contain a catalytic active site, capable of reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
Links
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Statistics
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PSSM-Id: 518729
Aligned: 10 rows
Threshold Bit Score: 208.827
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6GLB4       128 YKQLKKEVQGKKLVEGVLHFTGGHLDENLSGFPSFSGIARLSWLVDLFGDLIVTSATREEQKELNYSKLTAHFLTAEN-R 206 tropical clawed...
XP_040548444 128 YKQLKKEVAGKDLVKGTLHFTGSVLDETKAGFPAFSGIARLTWLIDLFGDLTITSASREEQKDKNYSRMTVHFQTANK-K 206
XP_069047190 134 YKQLKKDVTGKNLVEGTLHFTGGPL-QPGFGFIAFSGIARLTWLVDLFGELTVTSANVEEDKEKKYIKMTAHFQTKDK-S 211
XP_007250759 128 FKQLKKDIAGKQLEEGRLHFTGGPL-KPGFGFPAFSGISRLTWLVDLFGELSVKAATLEEDEDRKYSKMTAHFLTKDQ-K 205
3_pfamImport   1 FKALKRELEGKTLQEGTLHFTGGPL-KPTFGFPAFSGVARLTWLVELFGRLSVTAATLEEDPEKNYSKMTATLKTSSD-R 78 
XP_003456769 128 YKQLKREVEGKTLQEGTLHFTGGAL-KPGFGFPSFSGIARLTWLVELFGELSVSAATLEEDPANSYSKMTAKLLTSDN-R 205
XP_005809267 128 YKQLKKEVEGKTLLEGSLHFAGGAL-KPGFGFLAFSGIARLSWLADLFGELSVSAATFEEDAEQGYSKMTAQLLTSDS-K 205
XP_028919388 148 YISLKKEVSGKELVKGTLHFTAGPLDEERFGFPSFSGISRLSWLVDLFGELSLVSATMEEQKDKKYLKMTADLKTADQ-R 226
XP_056713739 128 YKQLKKEVEGKELVKGTLHFTGGPLDEERSGFPAFSGIARLTWLVDLFGDLTVMSAVREEEKERNYSRMTVHFQTANK-R 206 tarantolino
XP_056660796 202 FAFLKNEVAGKELMEGTLHFTGGPLDKGKFGFIAFSAISRLSWLVSLFGELSFISATMEERKEDQYQKMTVHLETVDKrR 281 gray short-tail...

Q6GLB4       207 PLTWVEERAPGMKRDKHIHFSFTTGILDTLPSSS 240 tropical clawed frog
XP_040548444 207 PLTWIEERGPGMRREKKINFCFTSGCLENFPQAP 240
XP_069047190 212 PLTWIEERAPGLGRVKNISFRFDTGVMDCLPVAP 245
XP_007250759 206 PLSWIEERGPGMGRTKRINLRFDSCTLTELPAGQ 239
3_pfamImport  79 SLTWIEERGPGFPRAKNIHFRLDGCTLTQIPAAP 112
XP_003456769 206 SLTWIEERQPGLPRAKNINFQFDSGTLTQIPPAP 239
XP_005809267 206 PLTWIEERQAGLPRTKKINFVFDGFTLTQIPPAP 239
XP_028919388 227 PLTWIEEKGPDLKREKHIKFSFTSGCLENLPAAP 260
XP_056713739 207 PLTWIEERAPGMKRDKTINFCFKSGCLERLPEAP 240 tarantolino
XP_056660796 282 PLTWIEERGPELKRERHVNFLFESGRLESLPPPA 315 gray short-tailed opossum
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