3RW6


Conserved Protein Domain Family
Tap-RNA_bind
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pfam09162: Tap-RNA_bind (This model is not part of the current CDD release)
Tap, RNA-binding
Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.
Links
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Statistics
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PSSM-Id: 518725
Aligned: 49 rows
Threshold Bit Score: 88.3859
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3RW6_A        24 WFKITIPYGRKYDKAWLLSMIQSKCS-VPFTPIEFHYENTRAQFFVEDASTASALKAVNYKI-LDRENRRISIIINSS-A 100 human
XP_009021889 120 WYKITIPHAKDLDKDFIIKSINGLLK-TPMMPWNFSYENKMATFNIKGTEEARAVKGVSKRI-TTPNGFKMIILVGPCaM 197
Q17MK6       130 WYEVKIPYGHKYEKEFILRSLVNAISpLIFIPQYWKVEDTAVSFYIEDFQAAEALQKIDRTI-GLPDGRKMIVIVRNS-N 207 yellow fever mo...
Q7QK79         8 WYEVRIPYGNKYEKEFILRSIQQAITpQMFIPLYYKANESGAVFFVEDFQAADAIMRANRSI-QTPDGRRMILVVRNN-P 85  Anopheles gambi...
XP_049531832 140 WYEVRIPYGQKYEKEFVLRSIQQAISpQIFIPRYYKAAESCATFYVEDFATAEAIQKMDRKI-DTPDGRKMILLVRSN-H 217
XP_029344670 119 WYSVFVPNVEDSDE--VLKIIQSYITpVVFYPYNKQYFDNALRFLVDDNKVAKVLHNASYKI-TQRDDRKLTIKVSSY-L 194
XP_012060862 131 WYRVTIPYGQKYEKDFIINTLLNYITpDVFVPILYKTSTTDASFYIDDYKTAVALQSCDYKI-TMSDGFKLQVKVKPG-F 208
XP_001631177 159 WHRVVVNRAKIHDKEWLIKRLQSSSE-EAFQPVEFHYMGESAVFFVEGSRAAEALKRVSHSI-TVKDGSKLIITVRPSqK 236
KAF8382567    84 W-RVKIPSGQKYGAPFILSTLSAHVE--NLKPIMPKMFSTEFVFFVRDDDAAHAIRSVHRRIkHAETGDRLNIITNLV-N 159 Pristionchus pa...
XP_046440295 116 WSKVTIPHGKKFEKDFILKTLLNASK-VSFIPIYYHIEGNNAVFFIEDSTAAEALSTLNKQI-TLHDGFKLIILVKWSpA 193 common water flea

3RW6_A       101 PPH 103 human
XP_009021889 198 PPT 200
Q17MK6       208 PQY 210 yellow fever mosquito
Q7QK79        86 PPT 88  Anopheles gambiae str. PEST
XP_049531832 218 PVF 220
XP_029344670 195 PPH 197
XP_012060862 209 PVY 211
XP_001631177 237 PFK 239
KAF8382567   160 APW 162 Pristionchus pacificus
XP_046440295 194 PNL 196 common water flea
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