6IG2


Conserved Protein Domain Family
Tam41_Mmp37

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pfam09139: Tam41_Mmp37 (This model is not part of the current CDD release)
Phosphatidate cytidylyltransferase, mitochondrial
Tam41 also known as MMp37 is a mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase)(EC:2.7.7.41) that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. It is required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. It is suggested that the N-terminal portion of Tam41 may possess the NTase (Nucleotide Transferase) fold, which is consistent with the CDP-DAG synthase function of Tam41. Furthermore, it has been shown that Tam41/MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolyzis of which is necessary for the translocation of proteins through the membrane.
Statistics
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PSSM-Id: 518712
Aligned: 109 rows
Threshold Bit Score: 224.377
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6IG2_A         1 MGSSHH-HHHHsSGLVPRGSHMSHHAKCT-----------VAQLLKQNLLTFENQRIQPEEELKENLTKVVNYFQAPI-- 66  Schizosaccharom...
A0ECV7         9 LKQFIQ-TLPQ-SELSFAYGSAVQPQFNYd----------YTKNKPMIDLIIAVDNVEEWHMQNIQINSTHYSGLSYYl- 75  Paramecium tetr...
XP_001018527  17 LDSIIQrDFPK-IDFAFGYGSGVFRQIGYd----------YSKDSPMIDLIFGVQDADEWHRMNLIKNPSHYSGLGYYl- 84 
XP_003524826   6 FRSFLQ-VLPP-VEFACVYGSSLHPSN--------------HDKTTMTDYILGVSDPKQWHSENLKLNKHHYASWMVHlg 69 
Q9SN75         9 LSSFLS-VLPP-VDFCCVYGSTLHPNN--------------QDKSKMVDYILGVSDPIKWHSANLKMNSDHYASWMVHlg 72  thale cress
CBI27230       9 LASLLK-FLPP-VEFCCVYGSALHPNN--------------YNKSTMVDYILGVSDPMQWHSQNLKMNRDHYASSMVYlg 72 
KAI5601075     9 LKSFLK-VLPP-VGFCCVYGSSLHPNN--------------NDKSTMVDYIIGVSDPKQWHSKNMELNEDHYASWMVPlg 72 
XP_002528146   9 LKNFLE-VLPS-VEFCCVYGSALHPNN--------------QDKSSMVDFILGVSDPRQWHSENLKLNRDHYASWMVHlg 72 
XP_002500022  10 LRAVLE-DVPP-VNHAFGYGSGVLPQPlrddegpsasardHAATGSVVDFVFAVDDPRAWHRRNMAMNPSHYAPHLRAl- 86 
XP_003057904   9 LGVVLN-DLPP-VVHAFAYGSAVFPQP--------------ASSGSVVDYVLAVDAPDEWHAANMAANPSHYAAHLRLl- 71 
6IG2_A        67 DVAVGYGSGVF-RQAGYSQKENPMID----------FIFQVEDPVKWHKINLQQNPSHYSFVKNFGPGFVSTLqeSF--- 132 Schizosaccharom...
A0ECV7        76 GSRFIQRMNVEiF--PIHFSPFVQYQ----------DLKLKYGVVSTKELIKDLENWKWLSIAGRMQKPIVTIqeFEd-- 141 Paramecium tetr...
XP_001018527  85 GSSYLHFLQQYiT--PVHFNPSIQVDsfd----qkrKLNIKYGVVDVKQLSKDLLKWNILTCSGRLHKPVKIIqlDQvq- 157
XP_003524826  70 GESLITGVADR-IGVGVHFNPFVTWN----------GKLFKYGVIQMHDLLQDVQYWEKFYLCGRLQKPVHIV--VDn-- 134
Q9SN75        73 GARLITNVADK-VGVGVHFNPFVNWN----------DRKLKYGVVRMHDLVQDILDWKRFYLSGRLQKPVHML--VDn-- 137 thale cress
CBI27230      73 GAKLITQVADE-IGVGVHFNPFVSVN----------DEMFKYGVVRMHDLVEDVLNWETFYLSGRLQKPVQVL--VDn-- 137
KAI5601075    73 GAKLITQVADK-IGVGVHFNPFVTWN----------DKMLKYGVVRMHDLVQDVLHWERFYLCGRLQKPVHIL--VDn-- 137
XP_002528146  73 GAKLITEVADE-IGVGVHFNPFITWN----------DKMLKYGVVRMHDLVQDILNWERFYLSGRLQKPVHIL--VDn-- 137
XP_002500022  87 GGGTVAALADR-VGAGVHYNTLIPWTktihpsarlaPTTFKYGVVSVNAMCDDLVNWRHMFVAGRMQKPVVALggAId-- 163
XP_003057904  72 GARSPGWIADR-VGVGVHYNTLLPWPctttr-phdgARLYKYGVVSVEALTRDLTRWSDLFVAGRMQKPTTTL--TTtta 147
6IG2_A       133 ------GTGVYYNTHVEVEGNIIKYGVTSKK-D---VYEDLKNWNTMYLAGRFQKPVVILKGEDEFYKENSYNLSSALHV 202 Schizosaccharom...
A0ECV7       142 -----lRFQRAFIANLQSALAVAILMD---FkSsmsLQELLYSVISLSYYGDIRFTLGGENQNKVFNILKGNYKNITDLY 213 Paramecium tetr...
XP_001018527 158 ----npTLNSDLRVNLIQATAISLLLN---FkPyieMKEFLMTIASLSYIGDVRFLFGAENKNKIQNLVEGNYDRFTHLY 230
XP_003524826 135 -----lDVNSTNSVNLRAAVSAALLLLPSEF-T---EEDLYAKVCSLSYTGDIRMLF-AEDKNKVKKIVTGQFDLFHSMY 204
Q9SN75       138 -----lDIEDVNSVNKRAAISAALLLLPSKF-T---EEDLYAKICSLSYMGDLRMFF-AEDTNKVNKIVKGQFDLFQSMY 207 thale cress
CBI27230     138 -----lDIGNLNSVNLKGAISAALLLLPAKF-T---EEHLYAKICSLSYMGDLRMLF-AEDRNKVKKIVQVQFDLFQTMY 207
KAI5601075   138 -----lDIGDVNSVNLRAAVSAALLLLPSKF-T---EEDLYSKICSLSYMGDLRMLF-AEDKNKVKRIVEGQFGLFQSMY 207
XP_002528146 138 -----lDIGNVNSANLRAALSAALLLLPSKF-T---EEDLYSKICSLSYMGDLRMLF-AEDKNKVKKIVQGQFGLFHSMY 207
XP_002500022 164 -----pRVTAAQSINARSALAAALLLLPEEF-S---REDLLGSLCGLSYAGDVRVALGAEDVDKVRRIATGSERGLMEMY 234
XP_003057904 148 afaadaSLRAASEANLRAALAAALLMLPETF-S---TRELHETLCGLSYEGDVRTAFGAEDVGKIPRVAAGSRAGLREMY 223
6IG2_A       203 GLLMLADRFTEFDLYKTIVSLSYlgdiRMSFAaeNPRKVENIVSKQIAFFRKLYLPLLYA------EPGVHFIESSEVLK 276 Schizosaccharom...
A0ECV7       214 LSNLGDLNNVIKIQ--------------KDGEvlIDNSIKSLEFLCSKIPGQLLSIVLGE--------KDNMGTLKMMSQ 271 Paramecium tetr...
XP_001018527 231 KDVIEQNNPINSLAQVVGNRAE-----HIKLE----TNSETVYQLVNCLPDGL---GLFA--------RTNEINVKIINL 290
XP_003524826 205 KPFLEEYEAKKLLRLSSTANNQ------IHAT--QDCDLSVACALVSALPPSIRSQISKNg----eLTETGRFIHDTKVS 272
Q9SN75       208 KPFLEECETKNLLRFSSAEASH------TKLV--QDSSLSATRSLVSSLPASVRSQMGKSlgekkfVSETGRVMGEVCIS 279 thale cress
CBI27230     208 KPLLEEYGAKGLLRFSSSDGHQ------AIIS--QDCGLSVARSLVSSLPSKVRSQMGMKlgektkLSESGRVLREVVVG 279
KAI5601075   208 KPFLKEYEAKELLTFSLPNSHQ------ATIS--QDCSLSMTHSLVHSLPPLVRRKMGMKlgemqvLKDSGRVLHEVVIG 279
XP_002528146 208 RPILQDYEAKELLRFSSSDYQ-------SNIS--QDCGLSVTRSLVRALPPLVRSKMGMKlgeeklWSDSGRFLHEVIIG 278
XP_002500022 235 RDAVKVVGSDLAGLTMGRGGEVW----S------RDGSPAARSALFATLPRETLHKTMSA--------------RMLVKF 290
XP_003057904 224 ADAIARFRSNPAIGLTAVGTSVD----RGDCDwgQDKSAAARSALLETLPRKALALAAVS------AGAGAEAAAAAIAS 293
6IG2_A       277 SM-DpsdNSRYLSFHQNITKDSISRLLNGLPLNLVKIL 313 Schizosaccharomyces pombe 972h-
A0ECV7       272 DR-----IKDLIKESVKRKNQFSSKRMLFYNLAMISPF 304 Paramecium tetraurelia
XP_001018527 291 ED-----VQRQIIERIRKINMGSSQKLILYNTLATSPT 323
XP_003524826 273 AReV---AANCLQRILRQRVMVSSARQAISGLLAVGGV 307
Q9SN75       280 SReE---AAKCMEKVMRRRVMVSSGRQAVSGFLAAGAI 314 thale cress
CBI27230     280 SReE---AAECMRGVLRRKVMVSSARQAVSGLVAVGGV 314
KAI5601075   280 SReE---AARSMQRIIRRTVMVSSARQAVSGFLAAGGI 314
XP_002528146 279 SReE---AAKCMHKVLRRTVMISSARQAISGLLAAGGI 313
XP_002500022 291 EDaGgrsAVESLRECLRGTVRKSSLRQLLAGLLATSPS 328
XP_003057904 294 RA-SperTRDVVRRAIDAIVFRSSARQLMSGILSTSPR 330
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