1HTJ


Conserved Protein Domain Family
RGS-like

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pfam09128: RGS-like 
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Regulator of G protein signalling-like domain
Members of this family adopt a structure consisting of twelve helices that fold into a compact domain that contains the overall structural scaffold observed in other RGS proteins and three additional helical elements that pack closely to it. Helices 1-9 comprise the RGS (pfam00615) fold, in which helices 4-7 form a classic antiparallel bundle adjacent to the other helices. Like other RGS structures, helices 7 and 8 span the length of the folded domain and form essentially one continuous helix with a kink in the middle. Helices 10-12 form an apparently stable C-terminal extension of the structural domain, and although other RGS proteins lack this structure, these elements are intimately associated with the rest of the structural framework by hydrophobic interactions. Members of the family bind to active G-alpha proteins, promoting GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways.
Statistics
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PSSM-Id: 401172
View PSSM: pfam09128
Aligned: 7 rows
Threshold Bit Score: 241.565
Threshold Setting Gi: 15826359
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HTJ_F       27 SDIIFQDLEKL----KSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQ--ASPKDSRSLGKDIWNIFLEKNA-PLRVKI 99   human
Q8R4H2      368 QCSCFQSIELL----KSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKQ--TNSKETRRVFLEFHQFFLDRSA-HLKVPV 440  house mouse
CAF97498    284 QCNSFNSIEQL----KSRPAHLAAFLHHVISQFDPAPVLCYLYADFYKQ--TNSKETRRVFMDLHNFFIDRGA-NLKVPV 356  spotted green p...
Q61210       40 QNSQFQSLEQV----KRRPAHLMALLQHVALQFEPGPLLCCLHADMLSS--LGPKEAKKAFLDFYHSFLEKTA-VLRVPV 112  house mouse
CAA92119    246 QGGPFSNLAEL----KTHPAHLAVFINYLLLHGNPSSLFFYLITDAYQSayGTAKEFRRWAFEIFSTFIIPNS-PMCIPN 320  Caenorhabditis ...
Q7PMK0      201 ENSPFRSLTQLleadKS--VYLAVFLNFVLTNSDPSALLFYMITMLYKE--GTVKDMRKWAYEIHSTFLVPGApLLCANV 276  Anopheles gambi...
KAE8592291   31 QCSCFQSMDLL----KSHPAHLAVFIHHVVSQFDPAAMLCYLYTDLYQQ--TNSKETRRVFLEFNQFFLEKAG-NLRVSV 103  tropical clawed...
1HTJ_F      100 PEXLQAEI----------DSRLRNSEDARGVLCEAQEAAXPEIQEQIHDYRTKRTLGlGSLYGENDLLD--LDGDPL--- 164  human
Q8R4H2      441 PEEISVDLek-------rRPELIPEDLHRLYIQTMQERVHPEVQRHLEDFRQKRSMGlTLAESELTKLDaeRDKDRGtl- 512  house mouse
CAF97498    357 PDSISADLdr-------rRTELIPEEINRQLVQTLQDSLLPDIQKNLEDFRQKRSMGlTVAEGELSRLDqeRIRDRVtl- 428  spotted green p...
Q61210      113 PPSVAFELdr-------tRPDLISEDVQRRFIQEVVQSQQAAVSRQLEDFRSKRLMGmTPWEQELSLLEpwIGKDRGnye 185  house mouse
CAA92119    321 SNQSVIQPidkimcmtaeHIGDSDTDTLKRIFVPGRQRAVTDINMYLNDFRQKKQLG-GQVSESTNQLThmVRGDMT--- 396  Caenorhabditis ...
Q7PMK0      277 DEALARDIdd------vlQKENDKAEILRMVFWRSRLKAKEMINQQLQQFQTKRTAGlGTMYGPNDQQLqmAKGDKV--- 347  Anopheles gambi...
KAE8592291  104 PDDVALELek-------rRPELIPEELHRQYIQTMQERLSEDVKKNLEDFKQKRSMGlTLAEGELSKLDadRLRDRNtm- 175  tropical clawed...
1HTJ_F      165 -RERQVA-EKQLAAL---GDIL---SAYA--ADRSAPXDFALNTYXSHAGIR 206  human
Q8R4H2      513 eKERACA-EQIVTKI---EEVLmtaQAVE--EERSSTMQYVILMYMKYLGVK 558  house mouse
CAF97498    429 eRERSYA-ENIISKI---EDILlttQTTE--EEKCTTMQYVIYTYMKHLGVR 474  spotted green pufferfish
Q61210      186 aRERHVA-ERLLSHL---EETQhtiST-D--EEKSAAVVTAISLYMRHLGVR 230  house mouse
CAA92119    397 -MEHRVG-EQMLFRC---LEQCsnsTDFDscEIRTQSIISSLATVIKIVLGK 443  Caenorhabditis elegans
Q7PMK0      348 -KEQRIIdETLLPKLqqyLDELereSPKE--DPKKSALCSALSTVLMRIFVT 396  Anopheles gambiae str. PEST
KAE8592291  176 eKERVCA-EQILQKI---DEILfssQTPE--DEKSNTIQYVILTYMKHLGVK 221  tropical clawed frog
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