2Y9Y


Conserved Protein Domain Family
HAND

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pfam09110: HAND 
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HAND
The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. The domain confers DNA and nucleosome binding properties to the protein.
Statistics
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PSSM-Id: 401158
View PSSM: pfam09110
Aligned: 103 rows
Threshold Bit Score: 57.5637
Threshold Setting Gi: 326426853
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2Y9Y_A         15 SIDNYYKDVLNT--GRSSTPSHPRMPKPHVFHSHQLQPPQLQVLYEKERMWTAKKTGYVPTMDDVKAAYgKisd------ 86   baker's yeast
CCD26704      703 SIDNYYRDVLTT--KKAVTPLQPRMPKPKVFYSHQLHSPLLNELYEKDRMWIAKKTKYVPTLDDVKVTYgEdlt------ 774  Naumovozyma d...
XP_003676292  697 nIDGYYRDVLTT--KKVVTPLQPRMPKPKVFYSHQLQSPILKDLYEKDRMWTAKKTKYTPTIEDVKVTYgEdls------ 768  Naumovozyma c...
CCK70892      742 iVDNYYKDILNP--RKPPAPVQPRMPKPRPFYSHQMQNPGLKDLYEKERFWIAKKTAYVPNDDDVKALYgDnls------ 813  Kazachstania ...
CCF55876      723 SIDNYYKDVLNT--KKAPTPAQPRMPKPRSFASHQLQRPELKDLYEKERYWIAKKTNYQPSLEDVKTTYgDnlt------ 794  Kazachstania ...
Q754V7        727 SIDNYYKGVLNTggARPNQAAVPRMPKPQPFNSHQLLPPQLKILYEKERMWMAKRTKYTPTMEDVKTTYgDies------ 800  Eremothecium ...
CCF59390      733 nIDGYYKDVLQTggHRGGTPVHSRMPRGHPYYSHQFQPPQLKVLYEKERLWLTKRAEYTPTLDDLKYVYgDdkee----- 807  Kazachstania ...
CCK72909      723 SVDGYYKGVLQA--RRAGTPSHSRMPRGRFFMSHQLQSAKLKFLYEKERMWLAKSNGYEPILDDARHTFpNsfdttgdse 800  Kazachstania ...
XP_002556121  719 nIDGYYKDVLNP--GRSTTPAQPKMPRPQPFHSHQLLSPQLKVLYEKERMWNTKKNNYVPTLEDVKTTYgEied------ 790  Lachancea the...
Q6CA54        672 gVNSYYKDIFLLqqQq---PRTMRPPKQVPLAEHQFFPPGLKALQDQELAFYRKQINYKVPYADIDVDAlEeg------- 741  Yarrowia lipo...
2Y9Y_A         87 --qeEQKEKLELLKLSVNNSQPLTEEEEKMKADWESEG 122  baker's yeast
CCD26704      775 --naEMKDKLKLLKESIDKAQPLTEEEEKSKQELEAKG 810  Naumovozyma dairenensis CBS 421
XP_003676292  769 --eaELLKKLDVMKETVENAQPLTEEEEKQKVQLESEG 804  Naumovozyma castellii CBS 4309
CCK70892      814 --keEMAQKLTLMKKTVKIAEPLTEEEEALKVKWETEG 849  Kazachstania naganishii CBS 8797
CCF55876      795 --deEKQTKLDFMQKSVETAEPLTEEEEKQRREWESEG 830  Kazachstania africana CBS 2517
Q754V7        801 --eeERASKLELLKIAVANAQPLTEEEEKNKAEWEREG 836  Eremothecium gossypii
CCF59390      808 -ddeNREQKLKLLKLMIANAQPFTETEENLKEELEKig 844  Kazachstania africana CBS 2517
CCK72909      801 gsqeNNANLLQLLKIMISNAQPLTEEEEEERVELEAEG 838  Kazachstania naganishii CBS 8797
XP_002556121  791 --eeEKQAKLNMLLLAVANAQPLTEEEEKQKAQLESEG 826  Lachancea thermotolerans CBS 6340
Q6CA54        742 ---eTKESKRAALNKEIADAEPLTEEQEALKRDYESEG 776  Yarrowia lipolytica
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