2Y9Y


Conserved Protein Domain Family
HAND
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pfam09110: HAND (This model is not part of the current CDD release)
HAND
The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. The domain confers DNA and nucleosome binding properties to the protein.
Links
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Statistics
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PSSM-Id: 518694
Aligned: 99 rows
Threshold Bit Score: 57.5695
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Y9Y_A         15 SIDNYYKDVLNTGr-SST------PSHPRMPKPHVFHSHQLQPPQLQVLYEKERMWTAKKTGYVPT------MDDVKAAY 81   brewer's yeast
XP_003679671  701 SVDDYYKEIIGGNq-KSSnkstpqPKAPRAPKLVQGQDFQFFPRELDALQKKEQLSFKKKVNYKVTasdfggETDSEDED 779 
Q08773        754 SVDDYYKEIIGGGs-KSAskqtpqPKAPRAPKVIHGQDFQFFPKELDALQEKEQLYFKKKVNYKVTsyditgDIRNEGSD 832  Saccharomyces...
XP_003686390  776 SVDDYYKDIIGGGs-KSKdkisksQKPPKAPKNINLQDFQFYPKELVPLLEKEQLAYKKKVNYRVTkydvseMSFNEDDL 854 
XP_001645753   23 SVDDYYKDIIGNs--KSKekaavqSKVPKAPKFIHGQDFQFFPKELEALQEKEQLYYKKKVNYKVSaydvgaTGSDDEYD 100 
Q6FQ29        703 SVDDYYKDIIGGG--SKSnkgtpqPKLPKAPKVTHGQDYQFFPKEFYELQEKEQLSYKKKINFKVTss--dvSIETEEDD 778  [Candida] gla...
XP_022465615  693 SVDDYYKEIIGGGs-SKSskmasnPKIPKAPKIVHGQDFQFYPKALDDLQTKEQLYFKKKVNYKVTsyditgASDADSDD 771 
XP_003956933  702 SVDDYYREIIGGGg-PKSskltpqPRAPRAPKVITGQDYQFFPKELDELQAKEQLSFKRKVGYKVTsyditgAADSDDEV 780 
Q752N7        698 SVDDYYKDIIGGAntKSSnknmpqPKLPRPPRTVQIQDFQFPAPCLNALQEKELLSYKKKVNYKVSth--dfTSDDEADE 775  Eremothecium ...
XP_003644523  699 SVDDYYKEIIGGAanKNSskttpqPKMPKAPRAVLIQDFQFPSPNLNFLQEKEQLSYKRKINYKVAsy--dlGSDDEEDD 776 

2Y9Y_A         82 gKisd---------------qeEQKEKLELLKLSVNNSQPLTEEEEKMKADWESEG 122  brewer's yeast
XP_003679671  780 -Grerepd--------aewcdeETSNKIRLRQEEIDSAEDFTAEDEEKKQQLISQa 826 
Q08773        833 -AeeeegeyknaanteghkgheELKRRIEEEQEKINSAPDFTQEDELRKQELISKa 887  Saccharomyces cerevisiae S288C
XP_003686390  855 -Sdndse----------tpadeNLKKKIKALQDAINNSEEFTKEDELEKQRLISKa 899 
XP_001645753  101 -Sqaddq-----------sdtkSVKEKIKELKEKIENAPEFTEEDEREKQRLLSES 144 
Q6FQ29        779 -Eegekqlt-------skekkaLTDAKIKEEQEKIDNAPDFTDEDELEKQRMLDTa 826  [Candida] glabrata
XP_022465615  772 -Enetsksk-------qsidgkDIEERVKEEQARIDSAPKFTEEDESEKQRLISla 819 
XP_003956933  781 -Eekdeadek-----skdvedyDLNRKIKEEQEKIDNAPTFTEEDEQEKQRLLSla 830 
Q752N7        776 ----------------------EISNKVTAEQAKIDNAEEFTEDDELAKQRCIEES 809  Eremothecium gossypii
XP_003644523  777 g---------------------SISERIASEQAKIDNAEEFTEEDELMKQKCIDES 811
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