1IYJ


Conserved Protein Domain Family
BRCA-2_OB3

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pfam09104: BRCA-2_OB3 
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BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.
Statistics
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PSSM-Id: 401153
View PSSM: pfam09104
Aligned: 28 rows
Threshold Bit Score: 152.036
Threshold Setting Gi: 568250967
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IYJ_D        648 LLPFSKLSDPAFQPPCSEVDVVGVVVSVvkpiGLAP-------LVYLS-----DECLHLLVVKFGIDLN----EDI-KPR 710  Norway rat
EFX81680     1312 VIAFSTANQPGFKPMFNELDIVGLVVFV----GLQQrp---fqTAILS-----DGN-TYFGVKCWASLEdyalADIiVVG 1378 common water ...
XP_008186509 1265 VVSFKSICSGTFLPLFGELDLVGIVVSDvnknNAYD-------EIYVS-----DKEMNIISILFRGNIKeygyDDMmYPG 1332 pea aphid
XP_008215761 1802 ctLIPDITAMSFDPKFCEFDTVGVVVST----GPAPhgmksfeVVNMAypkpnNAGSSYLSILFWNGVSsfgyQSIfSVG 1877 jewel wasp
ETN60573      968 VMPIGDIDGSTFRPAFSEFDTVGVVVYV----GTAEkkk--fqSIYLA-----DTAMDLLCVNFWYGLAeyayDDLiTER 1036 Anopheles dar...
XP_001237134 1810 VTPIGSIDVATFRPPFGEFDTVGVVVRV----GPAEtkk--fqSIYLA-----DTAMNLLCINFWHGLGeyayDDVvQER 1878 Anopheles gam...
Q16FF5       1481 LTRIADIETSNFRPMFNEFDTIGIVIQV----GAIEskk--fqTVYLA-----DIDKNLLCVNFWSGIKeyayEDVvRER 1549 yellow fever ...
XP_022524494 2500 FTIFRDLQNSAFSSPCGEVDVVGYVISIldrqGASP-------VLYLV-----DDKFDFVSVRSFSSLVqlalEDLvKPL 2567 Mexican tetra
XP_005157420 2598 CVRFRELQNPHFSSPCGEVDIVGYIVSIegkqGHCP-------VLHLV-----DENFDLVTVRTYSSLEqlavEELvKPR 2665 zebrafish
EGI61921     1383 CTSLDEIANSEFVPPYGEFDTVGLVCSV----GPAPygmrdfdAVHLAycktgSSESSYLSILFWQGIAsygyTEIlTVG 1458 Panamanian le...
1IYJ_D        711 VLIAASNLQWR---PESTSRVPTLFAGNFSVFSA-SPKEAHFQERVTNMKHAIE--NIDTFYKEAEKKLIQVLKG 779  Norway rat
EFX81680     1379 AFLAFSNLQWRataCRTVSKMQFAFIHEGTLVSS-RPALKHLDAALNDLKQSVK--DPAACVAEAEGQVDTLLGS 1450 common water flea
XP_008186509 1333 SIISGINIQFKg--FNQISPIPKLYNTEQSLFTT-IPKTEYILNIFNDYKIFMKkhENENFLICCQTKLSEIFNR 1404 pea aphid
XP_008215761 1878 ALIACTNLEWR---RNTSWNVAVAYCSERTVFTC-NPRPQYLNSGLRNLRALIQ--NPVAYAESCVEEITNELSK 1946 jewel wasp
ETN60573     1037 KLLCVANLQWRtisRQST--VPHSFATEYTTFTE-NPRQPHLRVAWDRFQVQLNaiDQEQFFRRCYERVRELNDn 1108 Anopheles darlingi
XP_001237134 1879 RLLCVSNLQWRtfsRQPAVGVPQSFATEYTTFTEqHARHGHLRAEWDRCQLQLDaiDRDRFFEQCAERLGELVav 1953 Anopheles gambiae ...
Q16FF5       1550 VVLCISNLQWRtinALSV--IPTAFATEYTTFSE-HSKSKHFVEEFQSLHATLKdvNLEVFYDECRFKIAELKDK 1621 yellow fever mosquito
XP_022524494 2568 TLLAISNLQLR----ELSGPVPRLYAGEQALFSV-NPKEAHLQEAMAHLKTFVQ--SYENFFSVAEEKLSNLLPs 2635 Mexican tetra
XP_005157420 2666 ALVAICNLQVR----VLSGPVPSLYAGEQALFSI-NPKESYLQEAMAHLKTFAQ--NYEQFFNLAEEKVSDVvps 2733 zebrafish
EGI61921     1459 SIVACSNLEWR---RATSWNVPAAYCTDRSTFTR-NPRRNHLYESFENLRNLIM--DPVKYAESCTFELNVELQK 1527 Panamanian leafcut...
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