1IYJ


Conserved Protein Domain Family
BRCA-2_OB3
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pfam09104: BRCA-2_OB3 (This model is not part of the current CDD release)
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.
Links
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Statistics
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PSSM-Id: 518688
Aligned: 24 rows
Threshold Bit Score: 163.615
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IYJ_B         646 RELLPFSKLSDPAFQPPCSEVDVVGVVVSVvkpiGLAP-------LVYLS-----DECLHLLVVKFGIDLN----EDI-K 708  Norway rat
XP_046444824  1311 RSVITFSTANQPGFKPMFNELDIVGLVVFV----GLQQrp---fhTAILS-----DGN-TYFGVKCWASLEdyalADIiV 1377
XP_001863104  1502 RRLTKIVDVDRSSFQPLYNEFDTVGVVVYV----GNSDtkk--fqIAYLA-----DASMNLLGVHFWSGIKeyayEDVvK 1570
ETN60573       966 RSVMPIGDIDGSTFRPAFSEFDTVGVVVYV----GTAEkkk--fqSIYLA-----DTAMDLLCVNFWYGLAeyayDDLiT 1034
XP_001237134  1808 RTVTPIGSIDVATFRPPFGEFDTVGVVVRV----GPAEtkk--fqSIYLA-----DTAMNLLCINFWHGLGeyayDDVvQ 1876
1_pfamImport     1 RFCTLIPDITAMSFDPKFCEFDTVGVVVST----GPAPhgmksfeVVNMAypkpnNAGSSYLSILFWNGVSsfgyQSIfS 76  
3_pfamImport     1 RDVVSFKSICSGTFLPLFGELDLVGIVVSDvnknNAYD-------EIYVS-----DKEMNIISILFRGNIKeygyDDMmY 68  
7_pfamImport     1 RVSACFVDLQNPEFQSLCGEVDLTGFVIQIvdgqGFSP-------AFYLA-----DGELNFVKVRCFSSFAqsglEDLvK 68  
12_pfamImport    1 RQFTIFRDLQNSAFSSPCGEVDVVGYVISIldrqGASP-------VLYLV-----DDKFDFVSVRSFSSLVqlalEDLvK 68  
XP_068069673  2594 RECVRFRELQNPHFSSPCGEVDIVGYIVSIegkqGHCP-------VLHLV-----DENFDLVTVRTYSSLEqlavEELvK 2661 zebrafish

1IYJ_B         709 PRVLIAASNLQWR---PESTSRVPTLFAGNFSVFSA-SPKEAHFQERVTNMKHAIE--NIDTFYKEAEKKLIQVLK 778  Norway rat
XP_046444824  1378 VGAFLAFSNLQWRamaCRTASKMQFAFIHEGTLVSS-RPALKHLDAALNDLKQSVK--DPAACVAEAEGQVGTLLG 1450
XP_001863104  1571 ERSLLCVSNLQWRsfsQQST--IPSSYATEYTTFSE-HPKADHLKEELRTLKATLEsiDLEQFYRDCTEKITSAKD 1643
ETN60573      1035 ERKLLCVANLQWRtisRQST--VPHSFATEYTTFTE-NPRQPHLRVAWDRFQVQLNaiDQEQFFRRCYERVRELND 1107
XP_001237134  1877 ERRLLCVSNLQWRtfsRQPAVGVPQSFATEYTTFTEqHARHGHLRAEWDRCQLQLDaiDRDRFFEQCAERLGELVA 1952
1_pfamImport    77 VGALIACTNLEWR---RNTSWNVAVAYCSERTVFTC-NPRPQYLNSGLRNLRALIQ--NPVAYAESCVEEITNELS 146 
3_pfamImport    69 PGSIISGINIQFKg--FNQISPIPKLYNTEQSLFTT-IPKTEYILNIFNDYKIFMKkhENENFLICCQTKLSEIFN 141 
7_pfamImport    69 PRVLLSLSNLQLR---GQSASPTPVVYAGDLTVFSA-NPKDAHLQESLSQNKNLRQ--SQENFFLIAEETLSRLVQ 138 
12_pfamImport   69 PLTLLAISNLQLR----ELSGPVPRLYAGEQALFSV-NPKEAHLQEAMAHLKTFVQ--SYENFFSVAEEKLSNLLP 137 
XP_068069673  2662 PRALVAICNLQVR----VLSGPVPSLYAGEQALFSI-NPKESYLQEAMAHLKTFAQ--NYEQFFNLAEEKVSDVVP 2730 zebrafish
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