1IYJ


Conserved Protein Domain Family
BRCA-2_OB1
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pfam09103: BRCA-2_OB1 (This model is not part of the current CDD release)
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.
Links
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Statistics
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PSSM-Id: 518687
Aligned: 76 rows
Threshold Bit Score: 86.8594
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IYJ_B         266 SALKKILERDDTAAKTLVLCVSDIISLSTNVSETSgskaSsedsNKVDTIELTDGWYAVKAQL--------------DPP 331  Norway rat
EPB88637       387 PVLRKILEQDDNSVKHMVLVIADIIKTENSSFYNt---------STKYRLVLSDGWYKIHSCI--------------DLR 443 
XP_002142569   691 SAIVKICEGDISVSVPLALKVLTY----------EqgiiDgicdNSKVIFTCTDGWYLIKICC--------------DFG 746 
XP_001465140   424 PALRKMVEGDISSASLVVLYMSSVSEERSSPHMR--------------IVTLSDGIYHLKVTC--------------DVP 475 
Q4DNW3         324 PALRVLTEGDVPASSLLVVSVVCLSLEERLAPHT-----S--------VGVISDGCYEIKVAL--------------DVP 376  Trypanosoma ...
Q4GZF5         930 PALRLIAEGDVQAASLVVVWVVSVSFEERLTPHT-----C--------TAVVSDGFYHVKVSL--------------DIP 982  Trypanosoma ...
Q7Y1C4         628 SAIKRILSGDAPASSMMVLCISAINPRTDN----GsqeaHcsdnCSNVKVELTDGWYSMNAAL--------------DVV 689  thale cress
XP_001017722  1717 SILKQIQEQDAVKSLNMVLIVANITKVNQYGCY---------------VLELSDGWYSFFVVVldhkhvisndlyqqNNK 1781
A0CSV2         233 TIIQEIWTNDQSLNQHMILLVVGVEQCQSRR-----------------ILELSDGWYSLFFVC--------------EQS 281  Paramecium t...
19_pfamImport    1 SILKKILNRDASSLSCVVLCIAAVLPYPADLQ--NdpidQecpaCFNLALVLTDGWYSVYAVP--------------DAP 64  

1IYJ_B         332 LLAL---VKSGRLTVGQKIITQGA------------ELvGSPDACAPLE------------------APDSLRLKISANS 378  Norway rat
EPB88637       444 MEHA---ITRKKLKIGHKLSICGA------------QIiGDKTAQSPLSi-----------------KESDTLLSITSNG 491 
XP_002142569   747 NLKC---SIKTF---PSKIFICGS------------TWkSNVELGHPLEie--------------ysIGDIPTLNVGLNL 794 
XP_001465140   476 LSNL---IREGVLKPGQRMAVCGA------------KS-LLHRQCAPTE------------------CEEQVVLSINYNC 521 
Q4DNW3         377 LTNL---VREGILRCGHKLLVCGA------------KM-LLKNFCSPVD------------------CRDDVVLSINYNC 422  Trypanosoma ...
Q4GZF5         983 LTNL---VRNGTLRCGQKIVTCGA------------RM-LRRDCCSPLE------------------CKDEVLLSINYNC 1028 Trypanosoma ...
Q7Y1C4         690 LTKQ---LNAGKLFVGQKLRILGA------------GLsGWATPTSPLEa----------------vISSTICLLLNING 738  thale cress
XP_001017722  1782 ILQLd-lIKRNKIYIGMKMYVNNL------------AK----PSVGNLEnmin----------pkqnILYQNVYEIFYNN 1834
A0CSV2         282 FDQI---YNR--IKIGQKLHVTNLkeypiifntsnvKI----ITQYPFT---------------------KLLVTTKINS 331  Paramecium t...
19_pfamImport   65 LATVlwnLHAKSSIIGTKIAAWNA------------LLqNSVEGIDPLEcaivcesqwkhplvaredLTRWPYLRLRYNS 132 

1IYJ_B         379 TR-PARWHS-KLGFFH 392  Norway rat
EPB88637       492 CL-PARWDE-KLGYHR 505 
XP_002142569   795 IRpLTKSKStKLGFHI 810 
XP_001465140   522 VR-AVAQQT-PLGVCH 535 
Q4DNW3         423 TR-PVDPTA-ALGFYQ 436  Trypanosoma cruzi
Q4GZF5        1029 TQ-PVGPSS-PLGLYH 1042 Trypanosoma brucei
Q7Y1C4         739 TY-RAHWAD-RLGFCK 752  thale cress
XP_001017722  1835 II-KAPANS-KLGICS 1848
A0CSV2         332 IK-KAQINS-KLGKQQ 345  Paramecium tetraurelia
19_pfamImport  133 TR-RVRFDT-RLGVER 146
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