2Q5T,1IKQ


Conserved Protein Domain Family
Exotox-A_bind
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pfam09101: Exotox-A_bind 
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Exotoxin A binding
Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for binding of the toxin to the alpha-2-macroglobulin receptor, with subsequent internalisation into endosomes. The domain adopts a thirteen-strand antiparallel beta jelly roll topology, which belongs to the Concanavalin A-like lectins/glucanases fold superfamily.
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Statistics
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PSSM-Id: 286224
Aligned: 4 rows
Threshold Bit Score: 464.214
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Q5T_A  10 EDELNIFDECRSPCSLTPEPGKPiQSKLSIpSDVVLD---EGVLYYSMTINDEQNDIKDE-DKGESIITIGefATVRATR 85  Vibrio cholerae
P11439  27 EEAFDLWNECAKACVLDLKDGVR-SSRMSV-DPAIADtngQGVLHYSMVLEGGNDALKLAiDNALSITSDG--LTIRLEG 102 Pseudomonas aeruginos...
Q5EK40  34 EDELNIFDECRSPCSLTPEPGKPiQSKLSIpSDVVLD---EGVLYYSMTINDEQNDIKDE-DKGESIITIGefATVRATR 109 Vibrio cholerae
1IKQ_A   2 EEAFDLWNECAKACVLDLKDGVR-SSRMSV-DPAIADtngQGVLHYSMVLEGGNDALKLAiDNALSITSDG--LTIRLEG 77  Pseudomonas aeruginosa

2Q5T_A  86 hyvnqdapfGVihlditTENGTKTYSYNRK-EGEFAINWLVPIGEDSPASIKISVDELDQQRNIIEVPKLYSIDLDNQTL 164 Vibrio cholerae
P11439 103 ---------GV------EPNKPVRYSYTRQaRGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELL 167 Pseudomonas aeruginos...
Q5EK40 110 hyvnqdapfGVihlditTENGTKTYSYNRK-EGEFAINWLVPIGEDSPASIKISVDELDQQRNIIEVPKLYSIDLDNQTL 188 Vibrio cholerae
1IKQ_A  78 ---------GV------EPNKPVRYSYTRQaRGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELL 142 Pseudomonas aeruginosa

2Q5T_A 165 EqwKTQGNVSFSVTRPEHN-----IAISWPSVSYKAAQKEGSRHKRWAHWHTGLALCWLVPMDAIYNYITQQNCTLGDNW 239 Vibrio cholerae
P11439 168 A--KLARDATFFVRAHESNemqptLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTW 245 Pseudomonas aeruginos...
Q5EK40 189 EqwKTQGNVSFSVTRPEHN-----IAISWPSVSYKAAQKEGSRHKRWAHWHTGLALCWLVPMDAIYNYITQQNCTLGDNW 263 Vibrio cholerae
1IKQ_A 143 A--KLARDATFFVRAHESNemqptLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTW 220 Pseudomonas aeruginosa

2Q5T_A 240 FGGSYETVAGTPkvitVKQGIEQKP--VEQRIHF 271 Vibrio cholerae
P11439 246 EGKIYRVLAGNP----AKHDLDIKPtvISHRLHF 275 Pseudomonas aeruginosa PAO1
Q5EK40 264 FGGSYETVAGTPkvitVKQGIEQKP--VEQRIHF 295 Vibrio cholerae
1IKQ_A 221 EGKIYRVLAGNP----AKHDLDIKPtvISHRLHF 250 Pseudomonas aeruginosa
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