Conserved Protein Domain Family
Lyase_N

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pfam09092: Lyase_N (490119 is an unknown moldel)
Lyase, N terminal
Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a jelly-roll fold topology consisting of a two-layered bent beta-sheet sandwich with one short alpha-helix. The convex beta sheet is composed of five antiparallel strands, whilst the concave beta-sheet contains five antiparallel beta-strands with a loop between two consecutive strands folding back onto the concave surface. This domain is required for binding of the protein to long glycosaminoglycan chains.
Statistics
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PSSM-Id: 490119
Aligned: 10 rows
Threshold Bit Score: 193.781
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013546223   28 NERLLSFEER--RVPSFV--TATDSRLTVSNEHYRDGTQSLCWSF-GPKSILSIKKDLKFEPKDPTGKDTYLSAFI---- 98   Bacteroides h...
1_pfamImport    1 QSSIIDFDGN--QLPDFVt-ASSGSTLSLSSTRYIMGQQSLKWEW-QAGSTMTIEHPITLVTDKVASKTWGRKATQvl-- 74  
WP_005845113   25 DDRMFSFERAakQEMSFL--HDATGRLSVSDAHFKNGSHSLCWDY-QGQGVLSLKKKLRFEAKDATGRDNYLSAFI---- 97   Prevotella de...
Q8A2I1         19 DERMFSFEEP--QLPACI--TGVQSQLGISGAHYKDGKHSLEWTF-EPNGKLELRKDLKFEKKDPTGKDLYLSAFI---- 89   Bacteroides t...
CCY39300       29 HERLLSFEAP--EVPSFI--SSENSQLSITTEHYKDGAQALNWKF-EPGSILSIRKDLQFEPKDPTGKDTYLSGFV---- 99  
CCZ87669       29 HERLLSFEEA---VPQEL--SGAGSTLSLSDEHYKDGSRSLRWTY-KPGAVLSLKKDLKFEAKDPTGKDTYLSAFI---- 98  
CDA77469       28 dTRVISFEEN--KVPD----NWKGAGLAINTAHYKDGKQSMQWTF-KPGETISLKKDVMFQKKDPTGKDLYLSTFT---- 96  
Q8A2F5         18 YAQVIGFEEK---VPETFk-VSGKGEVKLSSLFYKEGESSLEWDF-QPASTLDVQIE-PLSLNAKKEQQFGIT------- 84   Bacteroides t...
WP_022390064   18 ygIQYDFEDG--VIPTTIn-DIQKGTLSVSSDHAKMGTKSLRWDW-TATGAL-------FRVNDEVNIPYAIKAFSnrgg 86   Coprobacter f...
WP_014790153   16 qaGAQSFEGN--TLPQEVkiSGKKSTISLSDKYYKDGKQSLLWQWvAPQSTLVFASP---------DIAKSVKNFKkrag 84   Ornithobacter...
WP_013546223   99 --VWVYNEQAQ-DKTIEFEF---L-RNGKKCTSFPFGINFIGWRGAWVCYER-------DMQGT---------------- 148  Bacteroides h...
1_pfamImport   75 -sFWIYNETPV-DDYMIVDLgrgLgPSGAPDAGIKVKMNFSGWRTVGVSLQN-------DLEGReiegigfddnaegesg 145 
WP_005845113   98 --VWVYNEKPQ-ADSIVFRF---L-KDGRTCCSFPMYVNFKGWRGVWVCYER-------DMQGH---------------- 147  Prevotella de...
Q8A2I1         90 --VWIYNEQPQ-DAAIEFEF---L-KDGRKCASFPFGINFKGWRAAWVCYER-------DMQGT---------------- 139  Bacteroides t...
CCY39300      100 --VWIYNKKAT-DKSLNFEF---L-KDGKICSHFPMGLNFTGWRAAWVCYER-------DMQGT---------------- 149 
CCZ87669       99 --VWVYNEKAV-DKKITFQF---L-KDGKVCTSFPFGINFTGWRAAWVCYER-------DMEGT---------------- 148 
CDA77469       97 --GWFYNTKAI-NDSIRVGF---Y-KEGKECCHFNLRTAFTGWRAAWVCFER-------DMQGT---------------- 146 
Q8A2F5         85 --LWIYNEKPQ-QDSIRFEF---LnKAGEVSYWFTYHLQAAGWRACWISFAY-------MNGDK---------------- 135  Bacteroides t...
WP_022390064   87 lrMWIYSPKAMpGKSLQFIF---RnKTVRV-YTFDFNLNFTGWRACWIAFSDmwapgesDDVQP---------------- 146  Coprobacter f...
WP_014790153   85 vkLWVFNEKPQ-KTPLVFNF---VdAQGQVQYTFDFNLNFTGWRAAWISYSDmw---tpDGGKT---------------- 141  Ornithobacter...
WP_013546223  149 --------PETGMDEIRVVAP-EVK-GKLFIDHLITASKvDARQQTADLQVPF 191  Bacteroides helcogenes
1_pfamImport  146 grstiaggAKSDMDSIRFRAPlKAPaGIFYIDRVMLSID-DARYQWSDDHVKT 197 
WP_005845113  148 --------PVEGMNEMRIQAP-SIK-GRIFFDHLITAVKvDARQQTPDCQVPF 190  Prevotella dentalis
Q8A2I1        140 --------PEEGMNELRIVAP-NAK-GRLFIDHLITATKvDARQQTADLQVPF 182  Bacteroides thetaiotaomicron VPI-5482
CCY39300      150 --------PEIGMNEIRIVAP-DET-GELCIDHLLTAAKmDHRYQTADIQVPF 192 
CCZ87669      149 --------PEEGMNELRILAP-DVE-GELFIDHLIPASKvDARQQAADVQVPF 191 
CDA77469      147 --------PQEGMDEVRFTAPkSSE-GQICIDLMIPSVKtDHRHQTADRQVPF 190 
Q8A2F5        136 --------KDKNIVSYRLVAP-DRK-GRIFLDRLTFPEKkMNLRTTPDQQLPA 178  Bacteroides thetaiotaomicron
WP_022390064  147 --------TQQDIDELTIKAPeGVEsGTLYFDRWDFSSNiN-KQATPDAQIPK 190  Coprobacter fastidiosus
WP_014790153  142 --------TEKPIVAMNVISPkNVSnSHIFIDRVSFENYvD-RQATPDAQIPE 185  Ornithobacterium rhinotracheale
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