Conserved Protein Domain Family
MIF4G_like_2

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pfam09090: MIF4G_like_2 
MIF4G like
Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices.
Statistics
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PSSM-Id: 401145
View PSSM: pfam09090
Aligned: 98 rows
Threshold Bit Score: 124.347
Threshold Setting Gi: 284090170
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE02923       652 S---TDESPFAVDGRELAALL-KRKAPEEEIQAVIERIHSQA-LDIgG--LDPLVTSTDVFTTAVLWVGSKSLSHVLAAI 724  Ophiostoma p...
XP_002553872   581 LfftESSLPFSDLVQQIVNYF-HKQPLDRNISELVSILEKMK-VDNeTivVDFNRLAVTTLVQVLVFSGNRSISHANKYI 658  Lachancea th...
ybcl:Ecym_6080 578 LlfkNEAFPFHDKVQLILDYF-HKQQLEKNVSELESLLEDIR-TTCsAqiPDFDRFTVTLLIQALVYSGNRSLSHANKYI 655  Eremothecium...
Q754H6         582 LlfkNEVFPFHEKVQLILDYI-HKQPLEKNISELESLLEDIK-SAHgDkiPDFNRFTVTLLIQALVYSGNRSLSHANKYI 659  Eremothecium...
Q6CJM2         579 LyfrSPSFPFHENVTQLLDFF-HKQPDTRSVAELEGILKDIA-VNHgSiiEDFNRFTVTLLIQTIVFCGSRSLSHANKYI 656  Kluyveromyce...
XP_001487539   640 FyfgNNRLPLHEISNKVYEFLvAQWKPNEDLLDIYQELQDNL-SSHpAidAET--FTVNVFLQTYAYLGSRSIYSVVSLI 716  Meyerozyma g...
CAY08319       647 FnfsLPELPLHGVASKVYDFVvAHWKPNTDFDELCKEILEAT-KEFpDinGIK--FMINLIFQTYAYIGSRSIYSVVSIL 723  Scheffersomy...
Q6BLJ6         674 YnfsNSGLPLHEGSSKVYDLIiANWKPNSEFYDLYKEISTNL-DDYaSinSDK--FLINLFFQTYAYIGSRSIYSVVSLL 750  Debaryomyces...
EEQ37004       259 YefsNPALPLNEVANKLYDFIiANWRSNEQFNDMVNETLEAIkSSVvNvdSDK--VLINLLFQTYAYIGSRSIYSVVSIL 336  Clavispora l...
XP_004199049   650 YvfsNSGLPLNEISKTVYDFIiASWKPNDEFKNLYDQILESV-SEHpDinTDK--FLINLIFQTYAYIGSRSIYSVVSLF 726  Pichia farin...
EPE02923       725 ERTKDRLLDAg------AAS-------------------EAARAQILDAVMDFWAAHPGVAVSIAEKLLNYAILTPAVIV 779  Ophiostoma p...
XP_002553872   659 GDARTELLEI-------LGKiea--------------sqEQKERWIVEAIIRYWNCNSQNGYLIADTCKNFDLISSKSIL 717  Lachancea th...
ybcl:Ecym_6080 656 SDAKNDLVMI-------LGKial--------------sdVVKEQWIIEAVIRYWNCNSQNGFLIVDSFKHSELVTAKSIL 714  Eremothecium...
Q754H6         660 SDAKSDLVTI-------LEKmev--------------ppEVKEQWIIEAVIRYWNCNSQNGFLIVDSFKHSELVTAKSIL 718  Eremothecium...
Q6CJM2         657 DDSREELKAI-------MAQvev--------------spQIKDQWICEAVVRYWNSNSQTGYLILDSLRYNGLISNESVL 715  Kluyveromyce...
XP_001487539   717 SRDKLKLKYLlgapiddKDYvpgstfrfe-ernltqeqiDKRQNLAIDSIFRLWVNQSQMAFLLLEYLIEYKILQPIYLV 795  Meyerozyma g...
CAY08319       724 SRDVNKLKYLsgspieyTEQepkfeeq-----eispeeiTDRQNWIIESIFRVWIHQPQEVFLILEYLIEFGILKPENLV 798  Scheffersomy...
Q6BLJ6         751 SRDIIKLKFLsgveikdENYqasefqfpv--aelaeqhfDNKQNWIIDSIFRIWVHQPQVVFLILEYLIEFEVLKPKYLI 828  Debaryomyces...
EEQ37004       337 NRDIAKLKFVsgvevteEDYklsgtefqfpdlhltpeqlGNRQKWIIESILRIWIQQPQVAFLILEYLIEFGILNPQYLI 416  Clavispora l...
XP_004199049   727 ERDIVKLQFLsgveineEKYsgtdfkftk--lelsetqiANRQRWIVDSIFRIWIRQPQVAFLILEYLIEFGILQPQYLI 804  Pichia farin...
EPE02923       780 QWALKDpeasspsssssSSsPAplsSPNLAVNYVAELVFNTVDKVTRRvhqlvaskhasvaavatasdaldaakerqrnp 859  Ophiostoma p...
XP_002553872   718 DFSFLDd----------KG--R---NWGLVDATSIESTFRVLSELSSR-------------------------------- 750  Lachancea th...
ybcl:Ecym_6080 715 AFSFSDl----------NG--Q---NLGLVEATSIESTFRTLTQLALQ-------------------------------- 747  Eremothecium...
Q754H6         719 TFSLTDl----------NG--Q---NLGLVDATSIESTFRTLTELALQ-------------------------------- 751  Eremothecium...
Q6CJM2         716 NFSLTEq----------CG--V---NMSLVDSTSIESIFRILNELAMA-------------------------------- 748  Kluyveromyce...
XP_001487539   796 GKCLSl--------------ET---NLVIDNVACMESINRILESSYTT-------------------------------- 826  Meyerozyma g...
CAY08319       799 LKTLDl--------------EN---NLILENVSCMESMNRVLFNSSIA-------------------------------- 829  Scheffersomy...
Q6BLJ6         829 GKTLNl--------------AS---NLIIENVSCMESVNRILINFSKS-------------------------------- 859  Debaryomyces...
EEQ37004       417 RKALDp--------------DS---NLIINNVSCMESINRVLSTCAVG-------------------------------- 447  Clavispora l...
XP_004199049   805 EKALDv--------------NH---NLIVDNISCMESINRVLSNQIKK-------------------------------- 835  Pichia farin...
EPE02923       860 pppvlpaaaaadanldvamdeedngasaanalaeaalaqahadveaaraaeEAETKAMRDLFKMLNEALQPWLTSSagsg 939  Ophiostoma p...
XP_002553872   751 ------------------------------------------------------RDTSVETFIFVFERLVEIASNV---- 772  Lachancea th...
ybcl:Ecym_6080 748 ------------------------------------------------------QTSDISVFEFVFERLVTIANET---- 769  Eremothecium...
Q754H6         752 ------------------------------------------------------QASDISVFEFVFERLLEIINDT---- 773  Eremothecium...
Q6CJM2         749 ------------------------------------------------------ADKDVGSFEYVFNRLVGAANEV---- 770  Kluyveromyce...
XP_001487539   827 -----------------------------------------------------DRDEFNVLYQYLLERIIQNLSLL---- 849  Meyerozyma g...
CAY08319       830 ---------------------------------------------------TDKGDSFKKLILLLFNAITRNLNAI---- 854  Scheffersomy...
Q6BLJ6         860 -----------------------------------------------------SNDEFKVLTLKLFELIVNNLNEI---- 882  Debaryomyces...
EEQ37004       448 -------------------------------------------------------ESSKEVILLLFNLIVENLNYT---- 468  Clavispora l...
XP_004199049   836 -------------------------------------------------------EGSDKLILNLFDSIVKNINQT---- 856  Pichia farin...
EPE02923       940 tSFAAtfststSPDNDGEee----------------aKETKAWAERWQRVVQRRAAVEEA 983  Ophiostoma piceae UAMH 11346
XP_002553872   773 -VEELglsvdsEL-SASMadpdemqde-sadlqkldcSWKYEGCMGFVKSVLRKYADEYA 829  Lachancea thermotolerans CBS 6340
ybcl:Ecym_6080 770 -ISQLgmp-deEI-VAPLvdnesmldd--delsrldlMWKYESTMGFIKSILRKYSDEYS 824  Eremothecium cymbalariae DBVPG#7215
Q754H6         774 -VSQLgt--neEI-VAPSvdnetmldv--delarldlIWKYESAVGFIKSILRKYSDEYS 827  Eremothecium gossypii ATCC 10895
Q6CJM2         771 -LSQLnt--idPI-VVPDldqdiqatd--eelpsldlAWKYEAIMGFLKSVLRKYSDEFS 824  Kluyveromyces lactis
XP_001487539   850 ----Aegn---ndeIKITtefsdeeaddlekmnvidkQWLFYEYTGLLKSYLRKYYEEST 902  Meyerozyma guilliermondii ATCC 6260
CAY08319       855 -SGELqedkneI--IKITkdiedpeal--evskridqEWLFYEYKGLLKSYFRRYIKNSE 909  Scheffersomyces stipitis CBS 6054
Q6BLJ6         883 -TKTLetnnsdE--VTILkdfsdeesedielmnkvdnQWLFYEYKGLLKSYLRKFSIHNS 939  Debaryomyces hansenii
EEQ37004       469 -LGKIgvenpeTEEVKIItefsdedkndtelmakidlQWLFYEYRGLLKTYLRKFNLQHS 527  Clavispora lusitaniae ATCC 42720
XP_004199049   857 -LNSLreaevdNP-LKIVtefseeeienedvmeridnQWLLFEYKGLLKSYLRKFGEFNA 914  Pichia farinosa CBS 7064
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