2V1U,2QBY,1FNN,7JPO,2QBY,8S0E,4XGC,7JGR


Conserved Protein Domain Family
Cdc6_C
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pfam09079: Cdc6_C (This model is not part of the current CDD release)
CDC6, C terminal winged helix domain
The C terminal domain of CDC6 assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolyzis. Mutagenesis studies have shown that this domain is essential for appropriate Cdc6 activity.
Links
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Statistics
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PSSM-Id: 518673
Aligned: 172 rows
Threshold Bit Score: 56.4166
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2V1U_A       283 EVVRTLPLHAKLVLLSIMMLEDGG------RPASTGEIYERYKELTSTLGLEHVTLRRVSGIISELDMLGIVksrVVSRG 356 Aeropyrum pernix
XP_002501908 390 ETMRGLPQHQQMVLCAAVRLFRTAa----rKETALGVLNDQYTKLCKESKLKGLTSGEFSGVCTVLADLTLL---KVGPG 462
XP_003057629 334 DTMRSLPQQQQMVLCAAVRLFRVGggasrsRETKLGELHDKYSSLCKETAIKGMNSGQFSEVCAVLADQTLL---RLGKG 410
XP_002972533 296 ETIQALPKHSQMVLCSAVSLFRKRk-----RDAPLGELNKQYLGFCKTTGMRPVSSQEFSGICQLIADQGLL---GLSTA 367
XP_020524903 443 DTIQSLPQHQQIILCSSVKLFRQGn-----KDTTLGKLNKFYSDFCKSALIHPASMTEFSNMCRVLNDQGLL---KLGQS 514
KCW85460     422 DTIQILPQHQQIILCSAVKLFRGRq-----KDTTVGELHKSYLDVCKSTHIPAAGFLEFSSMCRVLNDQGLL---KLGQS 493
XP_015578773 445 DTIQSLPQHQQVILCSAVKFFRGGk-----KDTTIGELNKSYADICKSTMIPPVGFLEFLNMCTVLNDQGLL---KLGQS 516
XP_012844389 408 DTIQSLPQHQQIILCSAVKLFRGGk-----KDTTIGELNKSYTDVCKSASIPPVVISELLSMCQVLDDQGIL---KLGQA 479
XP_016501100 430 DTIQSLPQHQQIILCSALKLFRGKk-----KDATIGELNISYVDVCKSTLIPPVGIMELSNMCRVLGDQGIL---KVGQA 501
XP_017250157 405 ETIQSLPQHQQIILCSAVVLFRRAk-----KDTTIGELNKSYMDICKTTQIPPIGIMELSSMCRVLSDQGIL---KLGQS 476

2V1U_A       357 RYGKTREVSLDADRLAVENA 376 Aeropyrum pernix
XP_002501908 463 REDRQRKVSLGVHADDVVFA 482
XP_003057629 411 AEDRQRKVSLAVHEDDVTFA 430
XP_002972533 368 REDRLRKTKLQVDHDDVVFA 387
XP_020524903 515 REDRLRRVALKVDEADITFA 534
KCW85460     494 REDKLRRIALKVDEADITFA 513
XP_015578773 517 RDDKLRRVTLKVDAADITFA 536
XP_012844389 480 RDDKLKRVTLKIDGADIVFA 499
XP_016501100 502 REDKLRRVTLKVDEADITFA 521
XP_017250157 477 REEKLRRVSLKIDEADITFA 496
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