Conserved Protein Domain Family
Mer2

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pfam09074: Mer2 
Mer2
Mer2 (Rec107) forms part of a complex that is required for meiotic double strand DNA break formation. Mer2 increases in abundance and is phosphorylated during the prophase phase of cell division. Blocking double strand break formation results in delayed dephosphorylation and dissociation of Mer2 from the chromosome.
Statistics
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PSSM-Id: 401133
Aligned: 6 rows
Threshold Bit Score: 171.191
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001647040  10 S------TDGmlSSPVGKTGC-----SGRDNVSEADKQILEWAGKLELETVDLKEKASELTNVFNESNTKLLELVARLND 78 
Q6FJA7        14 S------TDI--SSSIDADDLl---hSGDSSLGEADKQIMEWAGKLELESIDLREKSEKLINTLTNMSQELMKVSSQLVK 82  [Candida] glabrata
CCD23967      18 S------IVI--SSPVRS--Sh---nSSPLKLNEADKEILKWAGKLELESCDLREKSSELIGLLKKNSTQLTSVISTLNE 84 
XP_003676113  24 discanssaleiSSPVKGSGCi---gNDAKKMSEADKQILKWAGKLELESCDLREKSSLLIGLLKRNSKELVTVIDSLTE 100
P21651        19 SehslmiTET--SSPFRSIFShsgkvANAGALEESDKQILEWAGKLELESMELRENSDKLIKVLNENSKTLCKSLNKFNQ 96  Saccharomyces c...
CCH59576       7 S------STT--ISPQKP--Tl---nSETPELTESDKQILTWASKLELESVDLREKSSSLSREVRRCSNVLSNKFDDFKD 73 
XP_001647040  79 HLgsi---egGDMKRSEADGFKSLIENLGAT-LKNglkesleSSSKTSNGVMNKMMkqlqmvtdcVEKHDSNTVTKSELT 154
Q6FJA7        83 QL--------ENCNHSKEEDIVDQVYKLDVN-INN-------QLQDWKKSFSDQLK---------SINHNSNLGQIKNLT 137 [Candida] glabrata
CCD23967      85 IVist-------kkNAVMKLIKKLEKQLTI--VQN-------QKVQSQNVVNKTVT---------LRSKRQRTDTKSNLE 139
XP_003676113 101 LTldlkndkeGSSDNEDIKEIKHLINQLSIK-LGK-------QIIKVQEDVKKRPT------------QTIQTDTDS--- 157
P21651        97 LL---------EQDAATNGNVKTLIKDLASQ-IEN-------QLDKVSTAMLSKGD---------EKKTKSDSSYRQVLV 150 Saccharomyces c...
CCH59576      74 KLidp----------keIKSIFDVLMDLSTRvIDQ-------QKAKISSAQLDEIAksii-elkdVKNHKEEG------- 128
XP_001647040 155 K-FLGDNNKQLLQEFDARFD-------------------EIMKSVDTTQDLVINCGKQLESIFGVMVSVSTEIKNLSDRQ 214
Q6FJA7       138 E-CMANQEANILGAIRHNSTilkdecrdiiksqelagapKLQRAVDYLHEIMHNMSCQTESMNELLLSIDKQLHNIDLAL 216 [Candida] glabrata
CCD23967     140 QdELEKLTAKFRRNIDDKHR-------------------QIIKSNECTQSMLFNVNKQLQDMGDVLLSMSNDLQTLSQRQ 200
XP_003676113 158 --LMEKWFNKVSSLMDRKQK-------------------KYMDSNDFTQSMLLNLNCQLQDLQEVMVSMSKNVEVLNTRQ 216
P21651       151 E-EISRYNSKITRHVTNKQH-------------------ETEKSMRCTQEMLFNVGSQLEDVHKVLLSLSKDMHSLQTRQ 210 Saccharomyces c...
CCH59576     129 -----EKFGKIFEEITKKFT-------------------LMENSVK-------SVNDQLSNVTTILFSMNKSLEDLSIRQ 177
XP_001647040 215 TTLE 218
Q6FJA7       217 IKEK 220 [Candida] glabrata
CCD23967     201 STLE 204
XP_003676113 217 MNLe 220
P21651       211 TALE 214 Saccharomyces cerevisiae S288C
CCH59576     178 SALE 181
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